Environment‐induced epigenetic reprogramming in genomic regulatory elements in smoking mothers and their children
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Author
Bauer, Tobias
Trump, Saskia
Ishaque, Naveed
Thürmann, Loreen
Bauer, Mario
Bieg, Matthias
Gu, Zuguang
Weichenhan, Dieter
Mallm, Jan‐Philipp
Röder, Stefan
Herberth, Gunda
Takada, Eiko
Mücke, Oliver
Winter, Marcus
Junge, Kristin M
Grützmann, Konrad
Rolle‐Kampczyk, Ulrike
Wang, Qi
Lawerenz, Christian
Borte, Michael
Polte, Tobias
Schlesner, Matthias
Schanne, Michaela
Wiemann, Stefan
Geörg, Christina
Stunnenberg, Hendrik G
Plass, Christoph
Rippe, Karsten
Mizuguchi, Junichiro
Herrmann, Carl
Eils, Roland
Lehmann, Irina
Note: Order does not necessarily reflect citation order of authors.
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https://doi.org/10.15252/msb.20156520Metadata
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Bauer, T., S. Trump, N. Ishaque, L. Thürmann, L. Gu, M. Bauer, M. Bieg, et al. 2016. “Environment‐induced epigenetic reprogramming in genomic regulatory elements in smoking mothers and their children.” Molecular Systems Biology 12 (3): 861. doi:10.15252/msb.20156520. http://dx.doi.org/10.15252/msb.20156520.Abstract
Abstract Epigenetic mechanisms have emerged as links between prenatal environmental exposure and disease risk later in life. Here, we studied epigenetic changes associated with maternal smoking at base pair resolution by mapping DNA methylation, histone modifications, and transcription in expectant mothers and their newborn children. We found extensive global differential methylation and carefully evaluated these changes to separate environment associated from genotype‐related DNA methylation changes. Differential methylation is enriched in enhancer elements and targets in particular “commuting” enhancers having multiple, regulatory interactions with distal genes. Longitudinal whole‐genome bisulfite sequencing revealed that DNA methylation changes associated with maternal smoking persist over years of life. Particularly in children prenatal environmental exposure leads to chromatin transitions into a hyperactive state. Combined DNA methylation, histone modification, and gene expression analyses indicate that differential methylation in enhancer regions is more often functionally translated than methylation changes in promoters or non‐regulatory elements. Finally, we show that epigenetic deregulation of a commuting enhancer targeting c‐Jun N‐terminal kinase 2 (JNK2) is linked to impaired lung function in early childhood.Other Sources
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4812527/pdf/Terms of Use
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