Biomaterials and emerging anticancer therapeutics: engineering the microenvironment

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Biomaterials and emerging anticancer therapeutics: engineering the microenvironment

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Title: Biomaterials and emerging anticancer therapeutics: engineering the microenvironment
Author: Gu, Luo; Mooney, David J.

Note: Order does not necessarily reflect citation order of authors.

Citation: Gu, Luo, and David J. Mooney. 2015. “Biomaterials and Emerging Anticancer Therapeutics: Engineering the Microenvironment.” Nat Rev Cancer 16 (1) (December 23): 56–66. doi:10.1038/nrc.2015.3.
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Abstract: The microenvironment is increasingly recognized to have key roles in cancer, and biomaterials provide a means to engineer microenvironments both in vitro and in vivo to study and manipulate cancer. In vitro cancer models using 3D matrices recapitulate key elements of the tumour microenvironment and have revealed new aspects of cancer biology. Cancer vaccines based on some of the same biomaterials have, in parallel, allowed for the engineering of durable prophylactic and therapeutic anticancer activity in preclinical studies, and some of these vaccines have moved to clinical trials. The impact of biomaterials engineering on cancer treatment is expected to further increase in importance in the years to come.
Published Version: doi:10.1038/nrc.2015.3
Other Sources: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4790726/
Terms of Use: This article is made available under the terms and conditions applicable to Open Access Policy Articles, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#OAP
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:28265471
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