Metachronous pancreatic cancer originating from disseminated founder pancreatic intraductal neoplasias (PanINs)

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Metachronous pancreatic cancer originating from disseminated founder pancreatic intraductal neoplasias (PanINs)

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Title: Metachronous pancreatic cancer originating from disseminated founder pancreatic intraductal neoplasias (PanINs)
Author: Imai, Koji; Karasaki, Hidenori; Ono, Yusuke; Sasajima, Junpei; Chiba, Shin‐ichi; Funakoshi, Hiroshi; Muraki, Miho; Hanaoka, Hideki; Furukawa, Takahisa; Furukawa, Hiroyuki; Kono, Toru; Nagashima, Kazuo; Mizukami, Yusuke

Note: Order does not necessarily reflect citation order of authors.

Citation: Imai, K., H. Karasaki, Y. Ono, J. Sasajima, S. Chiba, H. Funakoshi, M. Muraki, et al. 2015. “Metachronous pancreatic cancer originating from disseminated founder pancreatic intraductal neoplasias (PanINs).” The Journal of Pathology: Clinical Research 1 (2): 76-82. doi:10.1002/cjp2.8. http://dx.doi.org/10.1002/cjp2.8.
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Abstract: Abstract Clonal populations originated from benign‐looking ‘founder cells' may spread widely within pancreas instead of being localized in situ before frank pancreatic ductal adenocarcinoma (PDA) can be detected. Metachronous PDA is not common event, and we here sought to define potent origin of multiple PDAs developed in a woman using advanced genetics technologies. Curative resection of pancreatic head tumour was performed; however, ‘recurrent' lesions in the remnant pancreas were found 3.5 years later and total pancreatectomy was subsequently performed. The metachronous lesions were morphologically similar to the primary PDA. Using a next‐generation sequencing and digital PCR, all three PDAs were shown to possess rare somatic mutations in KRAS (p.T58I & p.Q61H). Curiously, identical KRAS mutations were found in low‐grade ‘intraepithelial' lesions, which localized in normal area of the pancreas and one of them possessed p53 mutation, which was also found in the PDAs. The footprint of the tumour evolution marked by mutational profiling supports a human correlate to the mouse models of ‘dissemination' occurring at the earliest stages of pancreatic neoplasia.
Published Version: doi:10.1002/cjp2.8
Other Sources: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4858137/pdf/
Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:29002398
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