Interactions of nanomaterials and biological systems: Implications to personalized nanomedicine
Author
Zhang, Xue-Qing
Xu, Xiaoyang
Bertrand, Nicolas
Pridgen, Eric
Swami, Archana
Published Version
https://doi.org/10.1016/j.addr.2012.08.005Metadata
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Zhang, Xue-Qing, Xiaoyang Xu, Nicolas Bertrand, Eric Pridgen, Archana Swami, and Omid C. Farokhzad. 2012. Interactions of Nanomaterials and Biological Systems: Implications to Personalized Nanomedicine. Advanced Drug Delivery Reviews 64 (13) (October): 1363–1384. doi:10.1016/j.addr.2012.08.005.Abstract
The application of nanotechnology to personalized medicine provides an unprecedented opportunity to improve the treatment of many diseases. Nanomaterials offer several advantages as therapeutic and diagnostic tools due to design flexibility, small sizes, large surface-to-volume ratio, and ease of surface modification with multivalent ligands to increase avidity for target molecules. Nanomaterials can be engineered to interact with specific biological components, allowing them to benefit from the insights provided by personalized medicine techniques. To tailor these interactions, a comprehensive knowledge of how nanomaterials interact with biological systems is critical. Herein, we discuss how the interactions of nanomaterials with biological systems can guide their design for diagnostic, imaging and drug delivery purposes. A general overview of nanomaterials under investigation is provided with an emphasis on systems that have reached clinical trials. Finally, considerations for the development of personalized nanomedicines are summarized such as the potential toxicity, scientific and technical challenges in fabricating them, and regulatory and ethical issues raised by the utilization of nanomaterials.Other Sources
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3517211/Terms of Use
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http://nrs.harvard.edu/urn-3:HUL.InstRepos:29293167
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