dc.contributor.author | Sahai, Vaibhav | en_US |
dc.contributor.author | Redig, Amanda J. | en_US |
dc.contributor.author | Collier, Katharine A. | en_US |
dc.contributor.author | Eckerdt, Frank D. | en_US |
dc.contributor.author | Munshi, Hidayatullah G. | en_US |
dc.date.accessioned | 2017-03-28T23:50:12Z | |
dc.date.issued | 2016 | en_US |
dc.identifier.citation | Sahai, Vaibhav, Amanda J. Redig, Katharine A. Collier, Frank D. Eckerdt, and Hidayatullah G. Munshi. 2016. “Targeting BET bromodomain proteins in solid tumors.” Oncotarget 7 (33): 53997-54009. doi:10.18632/oncotarget.9804. http://dx.doi.org/10.18632/oncotarget.9804. | en |
dc.identifier.issn | | en |
dc.identifier.uri | http://nrs.harvard.edu/urn-3:HUL.InstRepos:31731792 | |
dc.description.abstract | There is increasing interest in inhibitors targeting BET (bromodomain and extra-terminal) proteins because of the association between this family of proteins and cancer progression. BET inhibitors were initially shown to have efficacy in hematologic malignancies; however, a number of studies have now shown that BET inhibitors can also block progression of non-hematologic malignancies. In this Review, we summarize the efficacy of BET inhibitors in select solid tumors; evaluate the role of BET proteins in mediating resistance to current targeted therapies; and consider potential toxicities of BET inhibitors. We also evaluate recently characterized mechanisms of resistance to BET inhibitors; summarize ongoing clinical trials with these inhibitors; and discuss potential future roles of BET inhibitors in patients with solid tumors. | en |
dc.language.iso | en_US | en |
dc.publisher | Impact Journals LLC | en |
dc.relation.isversionof | doi:10.18632/oncotarget.9804 | en |
dc.relation.hasversion | http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5288238/pdf/ | en |
dash.license | LAA | en_US |
dc.subject | NUT midline carcinoma | en |
dc.subject | breast and prostate cancers | en |
dc.subject | lung cancers | en |
dc.subject | gastrointestinal cancers | en |
dc.subject | brain tumors | en |
dc.title | Targeting BET bromodomain proteins in solid tumors | en |
dc.type | Journal Article | en_US |
dc.description.version | Version of Record | en |
dc.relation.journal | Oncotarget | en |
dash.depositing.author | Redig, Amanda J. | en_US |
dc.date.available | 2017-03-28T23:50:12Z | |
dc.identifier.doi | 10.18632/oncotarget.9804 | * |
dash.contributor.affiliated | Redig, Amanda J | |