Schwann cells promote post-traumatic nerve inflammation and neuropathic pain through MHC class II

DSpace/Manakin Repository

Schwann cells promote post-traumatic nerve inflammation and neuropathic pain through MHC class II

Citable link to this page

 

 
Title: Schwann cells promote post-traumatic nerve inflammation and neuropathic pain through MHC class II
Author: Hartlehnert, Maike; Derksen, Angelika; Hagenacker, Tim; Kindermann, David; Schäfers, Maria; Pawlak, Mathias; Kieseier, Bernd C.; Meyer zu Horste, Gerd

Note: Order does not necessarily reflect citation order of authors.

Citation: Hartlehnert, Maike, Angelika Derksen, Tim Hagenacker, David Kindermann, Maria Schäfers, Mathias Pawlak, Bernd C. Kieseier, and Gerd Meyer zu Horste. 2017. “Schwann cells promote post-traumatic nerve inflammation and neuropathic pain through MHC class II.” Scientific Reports 7 (1): 12518. doi:10.1038/s41598-017-12744-2. http://dx.doi.org/10.1038/s41598-017-12744-2.
Full Text & Related Files:
Abstract: The activation of T helper cells requires antigens to be exposed on the surface of antigen presenting cells (APCs) via MHC class II (MHC-II) molecules. Expression of MHC-II is generally limited to professional APCs, but other cell types can express MHC-II under inflammatory conditions. However, the importance of these conditional APCs is unknown. We and others have previously shown that Schwann cells are potentially conditional APCs, but the functional relevance of MHC-II expression by Schwann cells has not been studied in vivo. Here, we conditionally deleted the MHC-II β-chain from myelinating Schwann cells in mice and investigated how this influenced post-traumatic intraneural inflammation and neuropathic pain using the chronic constriction injury (CCI) model. We demonstrate that deletion of MHC-II in myelinating Schwann cells reduces thermal hyperalgesia and, to a lesser extent, also diminishes mechanical allodynia in CCI in female mice. This was accompanied by a reduction of intraneural CD4+ T cells and greater preservation of preferentially large-caliber axons. Activation of T helper cells by MHC-II on Schwann cells thus promotes post-traumatic axonal loss and neuropathic pain. Hence, we provide experimental evidence that Schwann cells gain antigen-presenting function in vivo and modulate local immune responses and diseases in the peripheral nerves.
Published Version: doi:10.1038/s41598-017-12744-2
Other Sources: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5624882/pdf/
Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:34492292
Downloads of this work:

Show full Dublin Core record

This item appears in the following Collection(s)

 
 

Search DASH


Advanced Search
 
 

Submitters