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dc.contributor.authorRamirez, Franchesca
dc.contributor.authorMoscarello, J. M.
dc.contributor.authorLeDoux, J. E.
dc.contributor.authorSears, R. M.
dc.date.accessioned2018-07-27T19:30:37Z
dc.date.issued2015
dc.identifierQuick submit: 2018-01-19T17:48:02-0500
dc.identifier.citationRamirez, F., J. M. Moscarello, J. E. LeDoux, and R. M. Sears. 2015. “Active Avoidance Requires a Serial Basal Amygdala to Nucleus Accumbens Shell Circuit.” Journal of Neuroscience 35 (8) (February 25): 3470–3477. doi:10.1523/jneurosci.1331-14.2015.en_US
dc.identifier.issn0270-6474en_US
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:37308351
dc.description.abstractFreezing is a species-typical defensive reaction to conditioned threats. While the neural circuitry of aversive Pavlovian behavior has been extensively studied, less is known about the circuitry underlying more active responses to danger. Here we show that the flow of information between the basal amygdala (BA) and the nucleus accumbens (NAcc) is necessary for signaled active avoidance behavior. Rats trained to avoid shock by shuttling during an auditory conditioned stimulus showed increased expression of the activity-dependent protein c-Fos in the NAcc, specifically the shell subregion (NAccSh). Silencing neural activity in the NAccSh, but not in the adjacent NAcc core, disrupted avoidance behavior. Disconnection of the BA and the NAccSh was just as effective at disrupting avoidance behavior as bilateral NAccSh inactivations, suggesting learned avoidance behavior requires an intact BA-NAccSh circuit. Together, these data highlight an essential role for the amygdalar projection to the ventral striatum in aversively motivated actions.en_US
dc.description.sponsorshipPsychologyen_US
dc.language.isoen_USen_US
dc.publisherSociety for Neuroscienceen_US
dc.relation.isversionof10.1523/JNEUROSCI.1331-14.2015en_US
dash.licenseLAA
dc.subjecttwo-way signaled active avoidanceen_US
dc.subjectaversiveen_US
dc.subjectfear conditioningen_US
dc.subjectmotivationen_US
dc.subjectnegative reinforcementen_US
dc.titleActive Avoidance Requires a Serial Basal Amygdala to Nucleus Accumbens Shell Circuiten_US
dc.typeJournal Articleen_US
dc.date.updated2018-01-19T22:48:05Z
dc.description.versionVersion of Recorden_US
dc.relation.journalJournal of Neuroscienceen_US
dash.depositing.authorRamirez, Franchesca
dc.date.available2015
dc.date.available2018-07-27T19:30:37Z
dc.identifier.doi10.1523/JNEUROSCI.1331-14.2015*
workflow.legacycommentscat.completeen_US
dash.contributor.affiliatedRamirez, Franchesca


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