Reduced Microvascular Volume and Hemispherically Deficient Vasoreactivity to Hypercapnia in Acute Ischemia: MRI Study using Perm
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Suh, Ji-Yeon
Shim, Woo Hyun
Kwon, Sean Joo
Dai, George
Wang, Xiaoying
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https://doi.org/10.1038/jcbfm.2015.22Metadata
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Suh, J Y, Woo H Shim, Gyunggoo Cho, Xiang Fan, Seon J Kwon, Jeong K Kim, George Dai, Xiaoying Wang, and Young R Kim. 2015. “Reduced Microvascular Volume and Hemispherically Deficient Vasoreactivity to Hypercapnia in Acute Ischemia: MRI Study Using Permanent Middle Cerebral Artery Occlusion Rat Model.” J Cereb Blood Flow Metab 35 (6) (February 18): 1033–1043. doi:10.1038/jcbfm.2015.22.Abstract
Vasoreactivity to hypercapnia has been used for assessing cerebrovascular tone and control altered by ischemic stroke. Despite the high prognostic potential, traits of hypercapnia-induced hemodynamic changes have not been fully characterized in relation with baseline vascular states and brain tissue damage. To monitor cerebrovascular responses, T2- and T2*-weighted MRI images were acquired alternatively using spin- and gradient-echo EPI (GESE EPI) sequence with 5% CO2 gas inhalation in normal (n=5) and acute stroke rats (n=10). Dynamic relative changes in cerebrovascular volume (CBV), microvascular volume (MVV) and vascular size index (VSI) were assessed from regions of interest (ROIs) delineated by the percent decrease of apparent diffusion coefficient (ADC). The baseline CBV was not affected by MCAO whereas the baseline MVV in ischemic areas were significantly lower than that in the rest of the brain and correlated with ADC. Vasoreactivity to hypercapnic challenge was considerably attenuated in the entire ipsilesional hemisphere including normal ADC regions, in which unsolicited, spreading depression-associated increases of CBV and MVV were observed. The lesion-dependent inhomogeneity in baseline MVV indicates the effective perfusion reserve for accurately delineating the true ischemic damage while the cascade of 4 neuronal depolarization is probably responsible for the hemispherically lateralized changes in overall neurovascular physiologyOther Sources
http://pubmed.ncbi.nlm.nih.gov/25690471/Citable link to this page
https://nrs.harvard.edu/URN-3:HUL.INSTREPOS:37370430
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