dc.contributor.author | Song, Mingyang | |
dc.contributor.author | Everett, Christine | |
dc.contributor.author | Li, Chengchen | |
dc.contributor.author | Wilkinson, Jeremy | |
dc.contributor.author | Nguyen, Long | |
dc.contributor.author | McIver, Lauren | |
dc.contributor.author | Ivey, Kerry | |
dc.contributor.author | Izard, Jacques | |
dc.contributor.author | Palacios, Natalia | |
dc.contributor.author | Eliassen, A. | |
dc.contributor.author | Willett, Walter | |
dc.contributor.author | Ascherio, Alberto | |
dc.contributor.author | Sun, Qi | |
dc.contributor.author | Tworoger, Shelley | |
dc.contributor.author | Chang, Andrew | |
dc.contributor.author | Garrett, Wendy | |
dc.contributor.author | Huttenhower, Curtis | |
dc.contributor.author | Rimm, Eric | |
dc.contributor.author | Song, Mingyang | |
dc.date.accessioned | 2022-09-06T16:44:34Z | |
dc.date.issued | 2021-04-21 | |
dc.identifier.citation | Song, Mingyang, Christine Everett, Chengchen Li, Jeremy Wilkinson, Long Nguyen, Lauren McIver, Kerry Ivey et al. "Overview of the Microbiome Among Nurses study (Micro-N) as an example of prospective characterization of the microbiome within cohort studies." Nat Protoc 16, no. 6 (2021): 2724-2731. DOI: 10.1038/s41596-021-00519-z | |
dc.identifier.issn | 1754-2189 | en_US |
dc.identifier.issn | 1750-2799 | en_US |
dc.identifier.uri | https://nrs.harvard.edu/URN-3:HUL.INSTREPOS:37373153 | * |
dc.description.abstract | A lack of prospective studies has been a major barrier for assessing the role of the microbiome in human health and disease on a population-wide scale. To address this significant knowledge gap, we have launched a large-scale collection targeting fecal and oral microbiome specimens from 20,000 women within the Nurses’ Health Study II cohort (the Microbiome among Nurses, or Micro-N study). Leveraging the rich epidemiologic data that have been repeatedly collected from this cohort since 1989; the established biorepository of archived blood, urine, buccal cell, and tumor tissue specimens; the available genetic and biomarker data; the cohort's ongoing follow-up; and the BIOM-Mass microbiome research platform, Micro-N furnishes unparalleled resources for future prospective studies to interrogate the interplay between host, environmental factors, and the microbiome in human health. These prospectively collected materials will provide much-needed evidence to infer causality in microbiome-associated outcomes, paving the way towards development of microbiota-targeted modulators, preventives, diagnostics and therapeutics. Here, we describe a generalizable, scalable and cost-effective platform used for stool and oral microbiome specimen and metadata collection in the Micro-N study as an example of how prospective studies of the microbiome may be carried out. | en_US |
dc.language.iso | en_US | en_US |
dc.publisher | Springer Science and Business Media LLC | en_US |
dc.relation | Nature Protocols | en_US |
dash.license | META_ONLY | |
dc.subject | General Biochemistry, Genetics and Molecular Biology | en_US |
dc.title | Overview of the Microbiome Among Nurses study (Micro-N) as an example of prospective characterization of the microbiome within cohort studies | en_US |
dc.type | Journal Article | en_US |
dc.description.version | Accepted Manuscript | en_US |
dc.relation.journal | Nat Protoc | en_US |
dash.depositing.author | Eliassen, A. | |
dash.waiver | 2021-02-05 | |
dc.date.available | 2022-09-06T16:44:34Z | |
dash.affiliation.other | Harvard T.H. Chan School of Public Health | en_US |
dc.identifier.doi | 10.1038/s41596-021-00519-z | |
dash.waiver.reason | I'm the corresponding author for a manuscript that has been accepted for publication in Nature Protocols. I'm requesting a waiver that was asked by the Journal. See the email excerpt below.
"WAIVERS:
We have noted that one or more authors of the manuscript are from an institution that has an open access policy in place – which is incompatible with the business model for this journal. We would waivers from the Harvard School of Public Health and we would need waivers for Broad Institute of Harvard and MIT if if author has a faculty appointment with Harvard (FAS) or MIT.
As these authors are subject to their institutions’ respective open access policies and we will need you to provide us with a waiver from the institution of every affected author on the manuscript." | en_US |
dash.source.volume | 16 | en_US |
dash.source.page | 2724-2731 | en_US |
dash.source.issue | 6 | en_US |
dash.contributor.affiliated | Song, Mingyang | |
dash.contributor.affiliated | Everett, Christine | |
dash.contributor.affiliated | Wilkinson, Jeremy | |
dash.contributor.affiliated | McIver, Lauren | |
dash.contributor.affiliated | Chang, Andrew | |
dash.contributor.affiliated | Nguyen, Long | |
dash.contributor.affiliated | Palacios, Natalia | |
dash.contributor.affiliated | Garrett, Wendy | |
dash.contributor.affiliated | Tworoger, Shelley | |
dash.contributor.affiliated | Ascherio, Alberto | |
dash.contributor.affiliated | Sun, Qi | |
dash.contributor.affiliated | Eliassen, A. | |
dash.contributor.affiliated | Ivey, Kerry | |
dash.contributor.affiliated | Rimm, Eric | |
dash.contributor.affiliated | Huttenhower, Curtis | |
dash.contributor.affiliated | Willett, Walter | |