Genetic variants in ABO blood group region, plasma soluble E-selectin levels and risk of type 2 diabetes
Cornelis, Marilyn C.
Dam, Rob van
Girman, Cynthia J.
Laurie, Cathy C.
Mirel, Daniel B.
Hunter, David J.
Rimm, Eric Bruce::0ab2926c8242f35e5a982e3cf59f4987::600
Hu, Frank B.
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CitationQi, Lu, Marilyn C. Cornelis, Peter Kraft, Majken Jensen, Rob M. van Dam, Qi Sun, Cynthia J. Girman, et al. 2010. “Genetic Variants in ABO Blood Group Region, Plasma Soluble E-Selectin Levels and Risk of Type 2 Diabetes.” Human Molecular Genetics 19 (9): 1856–62. https://doi.org/10.1093/hmg/ddq057.
AbstractBlood soluble E-selectin (sE-selectin) levels have been related to various conditions such as type 2 diabetes. We performed a genome-wide association study among women of European ancestry from the Nurses' Health Study, and identified genome-wide significant associations between a cluster of markers at the ABO locus (9q34) and plasma sE-selectin concentration. The strongest association was with rs651007, which explained similar to 9.71% of the variation in sE-selectin concentrations. SNP rs651007 was also nominally associated with soluble intracellular cell adhesion molecule-1 (sICAM-1) (P = 0.026) and TNF-R2 levels (P = 0.018), independent of sE-selectin. In addition, the genetic-inferred ABO blood group genotypes were associated with sE-selectin concentrations (P = 3.55 x 10(-47)). Moreover, we found that the genetic-inferred blood group B was associated with a decreased risk (OR = 0.44, 0.27-0.70) of type 2 diabetes compared with blood group O, adjusting for sE-selectin, sICAM-1, TNF-R2 and other covariates. Our findings indicate that the genetic variants at ABO locus affect plasma sE-selectin levels and diabetes risk. The genetic associations with diabetes risk were independent of sE-selectin levels.
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