Browsing Harvard Medical School by Author "Lu, Kun Ping"
Now showing items 1-11 of 11
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Activation of β-Catenin Signaling in Prostate Cancer by Peptidyl-Prolyl Isomerase Pin1-Mediated Abrogation of the Androgen Receptor-β-Catenin Interaction
Chen, Shao-Yong; Wulf, Gerburg; Zhou, Xiao Zhen; Rubin, Mark A.; Lu, Kun Ping; Balk, Steven P. (American Society for Microbiology, 2006) -
Active Pin1 is a key target of all-trans retinoic acid in acute promyelocytic leukemia and breast cancer
Wei, Shuo; Kozono, Shingo; Kats, Lev; Nechama, Morris; Li, Wenzong; Guarnerio, Jlenia; Luo, Manli; You, Mi-Hyeon; Yao, Yandan; Kondo, Asami; Hu, Hai; Bozkurt, Gunes; Moerke, Nathan J.; Cao, Shugeng; Reschke, Markus; Chen, Chun-Hau; Rego, Eduardo M.; LoCoco, Francesco; Cantley, Lewis; Lee, Tae Ho; Wu, Hao; Zhang, Yan; Pandolfi, Pier Paolo; Zhou, Xiao Zhen; Lu, Kun Ping (2015)A common key regulator of oncogenic signaling pathways in multiple tumor types is the unique isomerase Pin1. However, available Pin1 inhibitors lack the required specificity and potency. Using mechanism-based screening, ... -
cis p-tau: early driver of brain injury and tauopathy blocked by antibody
Kondo, Asami; Shahpasand, Koorosh; Mannix, Rebekah; Qiu, Jianhua; Moncaster, Juliet; Chen, Chun-Hau; Yao, Yandan; Lin, Yu-Min; Driver, Jane A; Sun, Yan; Wei, Shuo; Luo, Man-Li; Albayram, Onder; Huang, Pengyu; Rotenberg, Alexander; Ryo, Akihide; Goldstein, Lee E; Pascual-Leone, Alvaro; McKee, Ann C.; Meehan, William; Zhou, Xiao Zhen; Lu, Kun Ping (2015)Traumatic brain injury (TBI), characterized by acute neurological dysfunction, is one of the best known environmental risk factors for chronic traumatic encephalopathy (CTE) and Alzheimer's disease (AD), whose defining ... -
Function and regulation of tau conformations in the development and treatment of traumatic brain injury and neurodegeneration
Albayram, Onder; Herbert, Megan K.; Kondo, Asami; Tsai, Cheng-Yu; Baxley, Sean; Lian, Xiaolan; Hansen, Madison; Zhou, Xiao Zhen; Lu, Kun Ping (BioMed Central, 2016)One of the two common hallmark lesions of Alzheimer’s disease (AD) brains is neurofibrillary tangles (NFTs), which are composed of hyperphosphorylated tau protein (p-tau). NFTs are also a defining feature of other ... -
Function of Drg1/Rit42 in p53-dependent Mitotic Spindle Checkpoint
Kim, Kyung-tae; Ongusaha, Pat P.; Hong, Young-Kwon; Kurdistani, Siavash K.; Nakamura, Masafumi; Lu, Kun Ping; Lee, Sam W. (American Society for Biochemistry and Molecular Biology, 2004)Mutations in the Drg1/RTP/Rit42 gene are commonly identified in hereditary neuropathies of the motor and sensory systems. This gene was also identified as a p53 target gene and a differentiation-related, putative metastatic ... -
Loss of Pin1 function in the mouse causes phenotypes resembling cyclin D1-null phenotypes
Liou, Yih-Cherng; Ryo, Akihide; Huang, Han-Kuei; Lu, Pei-Jung; Bronson, Roderick; Fujimori, Fumihiro; Uchida, Takafumi; Hunter, Tony; Lu, Kun Ping (National Academy of Sciences, 2002)Phosphorylation of proteins on serine/threonine residues preceding proline is a key signaling mechanism. The conformation and function of a subset of these phosphorylated proteins is regulated by the prolyl isomerase Pin ... -
Prolyl Isomerase Pin1 Regulates Neuronal Differentiation via β-Catenin
Nakamura, Kazuhiro; Kosugi, Isao; Lee, Daniel Y.; Hafner, Angela; Sinclair, David A.; Ryo, Akihide; Lu, Kun Ping (American Society for Microbiology, 2012) -
The Rab2A GTPase Promotes Breast Cancer Stem Cells and Tumorigenesis via Erk Signaling Activation
Luo, Man-Li; Gong, Chang; Chen, Chun-Hau; Hu, Hai; Huang, Pengyu; Zheng, Min; Yao, Yandan; Wei, Shuo; Wulf, Gerburg; Lieberman, Judy; Zhou, Xiao Zhen; Song, Erwei; Lu, Kun Ping (2015)SUMMARY Proline-directed phosphorylation is regulated by the prolyl isomerase Pin1, which plays a fundamental role in driving breast cancer stem-like cells (BCSCs). Rab2A is a small GTPase critical for vesicle trafficking. ... -
Sustained activation of Ras/Raf/mitogen-activated protein kinase cascade by the tumor suppressor p53
Lee, Sam W.; Fang, Li; Igarashi, Makoto; Ouchi, Toru; Lu, Kun Ping; Aaronson, Stuart A. (National Academy of Sciences, 2000)The p53 tumor suppressor gene can inhibit proliferation transiently, induce permanent cell-cycle arrest/senescence. or cause apoptosis depending on the cellular context. The mitogen-activated protein kinase (MAPK) cascade ... -
Telomeric Protein Pin2/TRF1 as an Important ATM Target in Response to Double Strand DNA Breaks
Kishi, Shuji; Zhou, Xiao Zhen; Ziv, Yael; Khoo, Christine; Hill, David E.; Shiloh, Yossi; Lu, Kun Ping (American Society for Biochemistry and Molecular Biology, 2001)ATM mutations are responsible for the genetic disease ataxia-telangiectasia (A-T). ATM encodes a protein kinase that is activated by ionizing radiation-induced double strand DNA breaks. Cells derived from A-T patients show ... -
The F-box Protein FBX4 Targets PIN2/TRF1 for Ubiquitin-mediated Degradation and Regulates Telomere Maintenance
Lee, Tae Ho; Perrem, Kilian; Harper, J. Wade; Lu, Kun Ping; Zhou, Xiao Zhen (American Society for Biochemistry and Molecular Biology, 2006)Pin2/TRF1 was identified previously as both a protein (TRF1) that binds to telomeric DNA repeats and as a protein (Pin2) that associates with the kinase NIMA and suppresses its mitosis inducing activity. Pin2/TRF1 negatively ...