Browsing Harvard Medical School by Title
Now showing items 1371-1390 of 18448
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Astrocytes mediate synapse elimination through MEGF10 and MERTK pathways
(2014)To achieve its precise neural connectivity, the developing mammalian nervous system undergoes extensive activity-dependent synapse remodeling. Recently microglial cells have been shown to be responsible for a portion of ... -
Astrocytes refine cortical connectivity at dendritic spines
(eLife Sciences Publications, Ltd, 2014)During cortical synaptic development, thalamic axons must establish synaptic connections despite the presence of the more abundant intracortical projections. How thalamocortical synapses are formed and maintained in this ... -
The ASTUTE Health study protocol: Deliberative stakeholder engagements to inform implementation approaches to healthcare disinvestment
(BioMed Central, 2012)Background: Governments and other payers are yet to determine optimal processes by which to review the safety, effectiveness, and cost-effectiveness of technologies and procedures that are in active use within health ... -
Asymmetric division coordinates collective cell migration in angiogenesis
(Springer Science and Business Media LLC, 2016-11-21)The asymmetric division of stem or progenitor cells generates daughters with distinct fates and regulates cell diversity during tissue morphogenesis1. However, roles for asymmetric division in other more dynamic morphogenetic ... -
Asymmetric formation of coated pits on dorsal and ventral surfaces at the leading edges of motile cells and on protrusions of immobile cells
(The American Society for Cell Biology, 2015)Clathrin/AP2-coated vesicles are the principal endocytic carriers originating at the plasma membrane. In the experiments reported here, we used spinning-disk confocal and lattice light-sheet microscopy to study the assembly ... -
Asymmetric neurotransmitter release enables rapid odor lateralization in Drosophila
(2012)In Drosophila, most individual olfactory receptor neurons (ORNs) project bilaterally to both sides of the brain1,2. Having bilateral rather than unilateral projections may represent a useful redundancy. However, bilateral ... -
Asymmetric Processing of Human Immunodeficiency Virus Type 1 cDNA in Vivo: Implications for Functional End Coupling during the Chemical Steps of DNA Transposition
(American Society for Microbiology, 2001) -
Asymmetric projections of the arcuate fasciculus to the temporal cortex underlie lateralized language function in the human brain
(Frontiers Media S.A., 2015)The arcuate fasciculus (AF) in the human brain has asymmetric structural properties. However, the topographic organization of the asymmetric AF projections to the cortex and its relevance to cortical function remain unclear. ... -
Asymmetric Requirement of Surface Epithelial β-Catenin During the Upper and Lower Jaw Development
(Wiley-Liss, Inc., 2012)Background: Intercellular communication between epithelial and mesenchymal cells is central to mammalian craniofacial development. β-catenin is the gateway of canonical Wnt signaling, one of the major evolutionarily conserved ... -
Asymmetry in facial expression
(American Association for the Advancement of Science (AAAS), 1980) -
Asymptomatic Extracranial Artery Stenosis and the Risk of Cardiovascular and Cerebrovascular Diseases
(Nature Publishing Group, 2016)Asymptomatic extracranial artery stenosis (ECAS) is a well-known risk factor for stroke events, but it remains unclear whether it has the same role in predicting cardiovascular and cerebrovascular diseases, especially in ... -
Asymptomatic Polyvascular Abnormalities in Community (APAC) Study in China: Objectives, Design and Baseline Characteristics
(Public Library of Science, 2013)Objective: The population-based “Asymptomatic Polyvascular Abnormalities in Community (APAC) Study was designed to examine prevalence and associations of asymptomatic polyvascular abnormalities (APA) in a general population. ... -
AT-RvD1 Modulates CCL-2 and CXCL-8 Production and NF-κB, STAT-6, SOCS1, and SOCS3 Expression on Bronchial Epithelial Cells Stimulated with IL-4
(Hindawi Publishing Corporation, 2015)Bronchial epithelial cells represent the first line of defense against microorganisms and allergens in the airways and play an important role in chronic inflammatory processes such as asthma. In an experimental model, both ... -
ATARiS: Computational quantification of gene suppression phenotypes from multisample RNAi screens
(Cold Spring Harbor Laboratory Press, 2013)Genome-scale RNAi libraries enable the systematic interrogation of gene function. However, the interpretation of RNAi screens is complicated by the observation that RNAi reagents designed to suppress the mRNA transcripts ... -
Ataxia induced by a thymic neuroblastoma in the elderly patient
(BioMed Central, 2015)Thymic neuroblastoma is a rare tumor with only few reports in modern literature. Whereas most data is taken from childhood neuroblastoma, little is known about the characteristics of the disease in the adult and elderly ... -
Ataxia, Dementia, and Hypogonadotropism Caused by Disordered Ubiquitination
(New England Journal of Medicine (NEJM/MMS), 2013)In recent years, we have seen great advances in the elucidation of genetic causes of cerebellar ataxia, with newly identified genes regulating a wide spectrum of cellular functions, including intracellular signaling, tau ... -
Ataxia-telangiectasia mutated (ATM) silencing promotes neuroblastoma progression through a MYCN independent mechanism
(Impact Journals LLC, 2015)Neuroblastoma, a childhood cancer with highly heterogeneous biology and clinical behavior, is characterized by genomic aberrations including amplification of MYCN. Hemizygous deletion of chromosome 11q is a well-established, ... -
Atelectasis Induced by Thoracotomy Causes Lung Injury during Mechanical Ventilation in Endotoxemic Rats
(The Korean Academy of Medical Sciences, 2008)Atelectasis can impair arterial oxygenation and decrease lung compliance. However, the effects of atelectasis on endotoxemic lungs during ventilation have not been well studied. We hypothesized that ventilation at low ... -
ATF4 licenses C/EBPβ activity in human mesenchymal stem cells primed for adipogenesis
(eLife Sciences Publications, Ltd, 2015)A well-established cascade of transcription factor (TF) activity orchestrates adipogenesis in response to chemical cues, yet how cell-intrinsic determinants of differentiation such as cell shape and/or seeding density ...