Browsing Harvard Medical School by Title
Now showing items 5643-5662 of 18465
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Endoglin regulates mural cell adhesion in the circulatory system
(Springer International Publishing, 2015)The circulatory system is walled off by different cell types, including vascular mural cells and podocytes. The interaction and interplay between endothelial cells (ECs) and mural cells, such as vascular smooth muscle cells ... -
Endometrial Intraepithelial Neoplasia Clinical Correlates and Outcomes
(Ovid Technologies (Wolters Kluwer Health), 2011)Objective To estimate cancer outcome and outcome predictors of women with endometrial intraepithelial neoplasia (EIN). Methods Outcomes of women with first diagnosis of EIN (“index biopsy”) was determined by ... -
Endometrial stromal beta-catenin is required for steroid-dependent mesenchymal-epithelial cross talk and decidualization
(BioMed Central, 2012)Background: Beta-catenin is part of a protein complex associated with adherens junctions. When allowed to accumulate to sufficient levels in its dephosphorylated form, beta-catenin serves as a transcriptional co-activator ... -
Endometriosis mimicking colonic stromal tumor
(Oxford University Press, 2015)Endometriosis is defined as the presence of endometrial glands and stroma at extra-uterine sites; it is a common disease affecting women of reproductive age. Endometrial tissue can implant itself to various organs, including ... -
Endometriosis-Associated Ovarian Cancer: A Review of Pathogenesis
(Molecular Diversity Preservation International (MDPI), 2013)Endometriosis is classically defined as the presence of endometrial glands and stroma outside of the endometrial lining and uterine musculature. With an estimated frequency of 5%–10% among women of reproductive age, ... -
Endomucin inhibits VEGF-induced endothelial cell migration, growth, and morphogenesis by modulating VEGFR2 signaling
(Springer Science and Business Media LLC, 2017-12) -
Endomucin prevents leukocyte–endothelial cell adhesion and has a critical role under resting and inflammatory conditions
(Nature Publishing Group, 2016)Endomucin is a membrane-bound glycoprotein expressed luminally by endothelial cells that line postcapillary venules, a primary site of leukocyte recruitment during inflammation. Here we show that endomucin abrogation on ... -
Endoneurial pathology of the needlestick-nerve-injury model of Complex Regional Pain Syndrome, including rats with and without pain behaviors
(Wiley-Blackwell, 2012)Current rodent models of neuropathic pain produce pain hypersensitivity in almost all lesioned animals and not all identified experimental effects are pain specific. 18G needlestick-nerve-injury (NNI) to one tibial nerve ... -
Endopeptidase-Mediated Beta Lactam Tolerance
(Public Library of Science, 2015)In many bacteria, inhibition of cell wall synthesis leads to cell death and lysis. The pathways and enzymes that mediate cell lysis after exposure to cell wall-acting antibiotics (e.g. beta lactams) are incompletely ... -
Endophenotype Network Models: Common Core of Complex Diseases
(Nature Publishing Group, 2016)Historically, human diseases have been differentiated and categorized based on the organ system in which they primarily manifest. Recently, an alternative view is emerging that emphasizes that different diseases often have ... -
Endophthalmitis
(Blackwell Publishing Ltd, 2013)Endophthalmitis means bacterial or fungal infection inside the eye involving the vitreous and/or aqueous humors. Most cases are exogenous and occur after eye surgery, after penetrating ocular trauma, or as an extension of ... -
The endoplasmic reticulum: structure, function and response to cellular signaling
(Springer International Publishing, 2015)The endoplasmic reticulum (ER) is a large, dynamic structure that serves many roles in the cell including calcium storage, protein synthesis and lipid metabolism. The diverse functions of the ER are performed by distinct ... -
Endoscopic photoconversion reveals unexpectedly broad leukocyte trafficking to and from the gut
(National Academy of Sciences, 2014)Given mounting evidence of the importance of gut-microbiota/immune-cell interactions in immune homeostasis and responsiveness, surprisingly little is known about leukocyte movements to, and especially from, the gut. We ... -
Endoscopic Surveillance of Patients With Hereditary Diffuse Gastric Cancer: Biopsy Recommendations After Topographic Distribution of Cancer Foci in a Series of 10 CDH1-mutated Gastrectomies
(Ovid Technologies (Wolters Kluwer Health), 2012)The management of hereditary diffuse-type gastric cancer revolves around surveillance biopsies and the timing of prophylactic gastrectomy. In the absence of a validated surveillance biopsy protocol, we modeled bioptic ... -
Endoscopic Ultrasound-Guided Pancreatobiliary Endoscopy in Surgically Altered Anatomy
(Korean Society of Gastrointestinal Endoscopy, 2016)Endoscopic retrograde cholangiopancreatography (ERCP) has become the mainstay of therapy for pancreatobiliary diseases. While ERCP is safe and highly effective in the general population, the procedure remains challenging ... -
Endoscopic ultrasound-guided techniques for diagnosing pancreatic mass lesions: Can we do better?
(Baishideng Publishing Group Inc, 2016)The diagnostic approach to a possible pancreatic mass lesion relies first upon various non-invasive imaging modalities, including computed tomography, ultrasound, and magnetic resonance imaging techniques. Once a suspect ... -
Endosomal GPCR signaling turned off by negative feedback actions of PKA and v-ATPase
(2014)The PTH receptor is one of the first GPCR found to sustain cAMP signaling after internalization of the ligand–receptor complex in endosomes. This unexpected model is adding a new dimension on how we think about GPCR ... -
Endothelial cell mitogens derived from retina and hypothalamus: biochemical and biological similarities
(Rockefeller University Press, 1984)Bovine retina and hypothalamus contain anionic endothelial cell mitogens that display unusual affinities for the negatively charged glycosaminoglycan heparin. Both growth factor activities are acidic polypeptides (pl's of ... -
Endothelial Differentiation Gene-1, a New Downstream Gene Is Involved in RTEF-1 Induced Angiogenesis in Endothelial Cells
(Public Library of Science, 2014)Related Transcriptional Enhancer Factor-1 (RTEF-1) has been suggested to induce angiogenesis through regulating target genes. Whether RTEF-1 has a direct role in angiogenesis and what specific genes are involved in RTEF-1 ...