Browsing Harvard Medical School by Title

Now showing items 294-313 of 18442

    • Activated Human CD4+CD45RO+ Memory T-Cells Indirectly Inhibit NLRP3 Inflammasome Activation through Downregulation of P2X7R Signalling 

      Beynon, Vanessa; Quintana, Francisco Javier; Weiner, Howard Lee (Public Library of Science, 2012)
      Inflammasomes are multi-protein complexes that control the production of pro-inflammatory cytokines such as IL-1β. Inflammasomes play an important role in the control of immunity to tumors and infections, and also in ...

    • Activated mouse \(CD4^+Foxp3^−\) T cells facilitate melanoma metastasis via Qa-1-dependent suppression of NK-cell cytotoxicity 

      Wang, Xiaojuan; Cui, Yanyan; Luo, Gaoxing; Wang, Qinghong; Hu, Jie; He, Weifeng; Yuan, Jun; Zhou, Junyi; Wu, Yan; Sun, Xiaofeng; Robson, Simon C; Li, Xianchang; Tan, Jiangling; Peng, Yanmeng; Xue, Gang; Lu, Linrong; Gao, Wenda; Wu, Jun (Nature Publishing Group, 2012)
      The regulatory activities of mouse \(CD^4+Foxp3^+\) T cells on various immune cells, including NK cells, have been well documented. Under some conditions, conventional \(CD4^+Foxp3^−\) T cells in the periphery are able to ...

    • Activated N-Ras signaling regulates arterial-venous specification in zebrafish 

      Ren, Chun-Guang; Wang, Lei; Jia, Xiao-E; Liu, Yi-Jie; Dong, Zhi-Wei; Jin, Yi; Chen, Yi; Deng, Min; Zhou, Yong; Zhou, Yi; Ren, Rui-Bao; Pan, Wei-Jun; Liu, Ting-Xi (BioMed Central, 2013)
      Background: The aberrant activation of Ras signaling is associated with human diseases including hematological malignancies and vascular disorders. So far the pathological roles of activated Ras signaling in hematopoiesis ...

    • Activated networking of platelet activating factor receptor and FAK/STAT1 induces malignant potential in BRCA1-mutant at-risk ovarian epithelium 

      Zhang, Lifang; Wang, Dan; Jiang, Wei; Edwards, Dale; Qiu, Weiliang; Barroilhet, Lisa M; Rho, Jung-hyun; Jin, Lianjin; Seethappan, Vanitha; Vitonis, Allison; Wang, Jianliu; Mok, Samuel C; Crum, Christopher Paul; Cramer, Daniel William; Ye, Bin (Springer Science + Business Media, 2010)
      Objectives It is essential to understand the molecular basis of ovarian cancer etiology and tumor development to provide more effective preventive and therapeutic approaches to reduce mortality. Particularly, the molecular ...

    • Activating Fc γ receptors contribute to the antitumor activities of immunoregulatory receptor-targeting antibodies 

      Bulliard, Yannick; Jolicoeur, Rose; Windman, Maurice; Rue, Sarah M.; Ettenberg, Seth; Knee, Deborah A.; Wilson, Nicholas S.; Dranoff, Glenn; Brogdon, Jennifer L. (The Rockefeller University Press, 2013)
      Fc γ receptor (FcγR) coengagement can facilitate antibody-mediated receptor activation in target cells. In particular, agonistic antibodies that target tumor necrosis factor receptor (TNFR) family members have shown ...

    • Activating Mutations in ERBB2 and Their Impact on Diagnostics and Treatment 

      Herter-Sprie, Grit S.; Greulich, Heidi E.; Wong, Kwok-Kin (Frontiers Media S.A., 2013)
      Despite the ongoing “war on cancer,” cancer remains one of the major causes of human morbidity and mortality. A new paradigm of targeted therapies holds the most promise for the future, making identification of tumor-specific ...

    • Activation During Sinus Rhythm in Ventricles With Healed Infarction 

      Rottmann, Markus; Kleber, Andre; Barkagan, Michael; Sroubek, Jakub; Leshem, Eran; Shapira-Daniels, Ayelet; Buxton, Alfred; Anter, Elad (Ovid Technologies (Wolters Kluwer Health), 2019-10)
      Background: In infarct-related ventricular tachycardia (VT), the circuit often corresponds to a location characterized by activation slowing during sinus rhythm (SR). However, the relationship between activation slowing ...

    • Activation of AKR1C1/ERβ induces apoptosis by downregulation of c-FLIP in prostate cancer cells: A prospective therapeutic opportunity 

      Yun, Huiyoung; Xie, Jianping; Olumi, Aria F.; Ghosh, Rita; Kumar, Addanki P. (Impact Journals LLC, 2015)
      We provide first-time evidence for ERβ-mediated transcriptional upregulation of c-FLIP as an underlying mechanism in the development of castrate-resistant cancer. While androgens inhibit apoptosis partly through transcriptional ...

    • Activation of caspase-1 by the NLRP3 inflammasome regulates the NADPH oxidase NOX2 to control phagosome function 

      Sokolovska, Anna; Becker, Christine E.; Eddie Ip, WK; Rathinam, Vijay A.K.; Brudner, Matthew; Paquette, Nicholas; Tanne, Antoine; Vanaja, Sivapriya K.; Moore, Kathryn J.; Fitzgerald, Katherine A.; Lacy-Hulbert, Adam; Stuart, Lynda M. (2013)
      Phagocytosis is a fundamental cellular process that is pivotal for immunity as it coordinates microbial killing, innate immune activation and antigen presentation. An essential step in this process is phagosome acidification, ...

    • Activation of Caspase-2 in Apoptosis 

      Li, Honglin; Bergeron, Louise; Cryns, Vince; Pasternack, Mark S.; Zhu, Hong; Shi, Lianfa; Greenberg, Arnold; Yuan, Junying (American Society for Biochemistry and Molecular Biology, 1997)

    • Activation of Cytomegalovirus in Pig-to-Primate Organ Xenotransplantation 

      Mueller, Nicolas; Barth, Rolf; Yamamoto, Shin; Kitamura, Hiroshi; Patience, Clive; Yamada, Kazuhiko; Cooper, David K. C.; Sachs, David H.; Kaur, Amitinder; Fishman, Jay Alan (American Society for Microbiology, 2002)
      Xenotransplantation of porcine organs carries the risk of reactivation of latent virus in donor and recipient tissues as well as transmission of viruses between species. We have investigated the activation of baboon ...

    • Activation of ERK1/2 by Store-Operated Calcium Entry in Rat Parotid Acinar Cells 

      Soltoff, Stephen P.; Lannon, William A. (Public Library of Science, 2013)
      The regulation of intracellular Ca2+ concentration ([Ca2+]i) plays a critical role in a variety of cellular processes, including transcription, protein activation, vesicle trafficking, and ion movement across epithelial ...

    • Activation of mechanosensitive ion channel TRPV4 normalizes tumor vasculature and improves cancer therapy 

      Adapala, Ravi K.; Thoppil, Roslin J.; Ghosh, Kaustabh; Cappelli, Holly; Dudley, Andrew C.; Paruchuri, Sailaja; Keshamouni, Venkateshwar; Klagsbrun, Michael; Meszaros, J. Gary; Chilian, William M.; Ingber, Donald E.; Thodeti, Charles K. (2016)
      Tumor vessels are characterized by abnormal morphology and hyper-permeability that together cause inefficient delivery of chemotherapeutic agents. Although VEGF has been established as a critical regulator of tumor ...

    • Activation of Multiple Proto-oncogenic Tyrosine Kinases in Breast Cancer via Loss of the PTPN12 Phosphatase 

      Sun, Tingting; Aceto, Nicola; Meerbrey, Kristen L.; Kessler, Jessica D.; Zhou, Chunshui; Migliaccio, Ilenia; Nguyen, Don X.; Pavlova, Natalya N.; Botero, Maria; Huang, Jian; Bernardi, Ronald J.; Schmitt, Earlene; Hu, Guang; Li, Mamie Z.; Dephoure, Noah; Rao, Mitchell; Creighton, Chad J.; Hilsenbeck, Susan G.; Shaw, Chad A.; Muzny, Donna; Gibbs, Richard A.; Wheeler, David A.; Osborne, C. Kent; Schiff, Rachel; Bentires-Alj, Mohamed; Westbrook, Thomas F.; Elledge, Stephen; Gygi, Steven (Elsevier BV, 2011-03)
      Among breast cancers, triple-negative breast cancer (TNBC) is the most poorly understood and is refractory to current targeted therapies. Using a genetic screen, we identify the PTPN12 tyrosine phosphatase as a tumor ...

    • Activation of necroptosis in human and experimental cholestasis 

      Afonso, Marta B; Rodrigues, Pedro M; Simão, André L; Ofengeim, Dimitry; Carvalho, Tânia; Amaral, Joana D; Gaspar, Maria M; Cortez-Pinto, Helena; Castro, Rui E; Yuan, Junying; Rodrigues, Cecília M P (Nature Publishing Group, 2016)
      Cholestasis encompasses liver injury and inflammation. Necroptosis, a necrotic cell death pathway regulated by receptor-interacting protein (RIP) 3, may mediate cell death and inflammation in the liver. We aimed to investigate ...

    • Activation of PI3K/Akt and MAPK pathways regulates Myc-mediated transcription by phosphorylating and promoting the degradation of Mad1 

      Zhu, Jidong; Blenis, John; Yuan, Junying (National Academy of Sciences, 2008)
      Mad1, a member of the Myc/Max/Mad family, suppresses Myc-mediated transcriptional activity by competing with Myc for heterodimerization with its obligatory partner, Max. The expression of Mad1 suppresses Myc-mediated cell ...

    • Activation of PI3K/mTOR Pathway Occurs in Most Adult Low-Grade Gliomas and Predicts Patient Survival 

      Perez, Daniel A.; Polley, Mei-Yin; Vandenberg, Scott R.; Zheng, Shichun; Lamborn, Kathleen R.; Wiencke, John K.; Chang, Susan M.; Prados, Michael D.; Berger, Mitchel S.; Stokoe, David; Haas-Kogan, Daphne A.; McBride, Sean Matthew; Smith, Justin S. (Springer US, 2009)
      Recent evidence suggests the Akt-mTOR pathway may play a role in development of low-grade gliomas (LGG). We sought to evaluate whether activation of this pathway correlates with survival in LGG by examining expression ...

    • Activation of PKC-δ and SHP-1 by hyperglycemia causes vascular cell apoptosis and diabetic retinopathy 

      Geraldes, Pedro; Hiraoka-Yamamoto, Junko; Matsumoto, Motonobu; Clermont, Allen Charles; Leitges, Michael; Marette, Andre; Aiello, Lloyd Paul; Kern, Timothy S; King, George Liang (Nature Publishing Group, 2009)
      Cellular apoptosis induced by hyperglycemia occurs in many vascular cells and is crucial for the initiation of diabetic pathologies. In the retina, pericyte apoptosis and the formation of acellular capillaries, the most ...

    • Activation of the central nervous system induced by micro-magnetic stimulation 

      Park, Hyun-Joo; Bonmassar, Giorgio; Kaltenbach, James A.; Machado, Andre G.; Manzoor, Nauman F.; Gale, John T. (2013)
      Electrical and transcranial magnetic stimulation have proven to be therapeutically beneficial for patients suffering from neurological disorders. Moreover, these stimulation technologies have provided invaluable tools for ...

    • Activation of the Connective Tissue Growth Factor (CTGF)-Transforming Growth Factor β 1 (TGF-β 1) Axis in Hepatitis C Virus-Expressing Hepatocytes 

      Nagaraja, Tirumuru; Chen, Li; Balasubramanian, Anuradha; Groopman, Jerome Elliot; Ghoshal, Kalpana; Jacob, Samson T.; Leask, Andrew; Brigstock, David R.; Anand, Appakkudal R.; Ganju, Ramesh K. (Public Library of Science, 2012)
      Background: The pro-fibrogenic cytokine connective tissue growth factor (CTGF) plays an important role in the development and progression of fibrosis in many organ systems, including liver. However, its role in the ...