Browsing Harvard Medical School by Title

Now showing items 5623-5642 of 18442

    • Encoding Cortical Dynamics in Sparse Features 

      Khan, Sheraz; Lefèvre, Julien; Baillet, Sylvain; Michmizos, Konstantinos P.; Ganesan, Santosh; Kitzbichler, Manfred G.; Zetino, Manuel; Hämäläinen, Matti S.; Papadelis, Christos; Kenet, Tal (Frontiers Media S.A., 2014)
      Distributed cortical solutions of magnetoencephalography (MEG) and electroencephalography (EEG) exhibit complex spatial and temporal dynamics. The extraction of patterns of interest and dynamic features from these cortical ...

    • Encoding visual information in retinal ganglion cells with prosthetic stimulation 

      Freeman, Daniel K; Rizzo, Joseph F; Fried, Shelley (IOP Publishing, 2011-05-18)
      Retinal prostheses aim to restore functional vision to those blinded by outer retinal diseases using electric stimulation of surviving retinal neurons. The ability to replicate the spatiotemporal pattern of ganglion cell ...

    • End-of-Life Care for Older Patients With Ovarian Cancer Is Intensive Despite High Rates of Hospice Use 

      Wright, A. A.; Hatfield, Laura Anne; Earle, C. C.; Keating, Nancy Lynn (American Society of Clinical Oncology (ASCO), 2014)
      Purpose: To date, few studies have examined end-of-life care for patients with ovarian cancer. One study documented increased hospice use among older patients with ovarian cancer from 2000 to 2005. We sought to determine ...

    • Endobiont Viruses Sensed by the Human Host – Beyond Conventional Antiparasitic Therapy 

      Fichorova, Raina N.; Lee, Yujin; Yamamoto, Hidemi; Takagi, Yuko; Hayes, Gary R.; Goodman, Russell P.; Chepa-Lotrea, Xenia; Buck, Olivia R.; Murray, Ryan; Kula, Tomasz; Beach, David H.; Singh, Bibhuti N.; Nibert, Max L. (Public Library of Science, 2012)
      Wide-spread protozoan parasites carry endosymbiotic dsRNA viruses with uncharted implications to the human host. Among them, Trichomonas vaginalis, a parasite adapted to the human genitourinary tract, infects globally ∼250 ...

    • Endocrine and Metabolic Pathways Linked to Keratoconus: Implications for the Role of Hormones in the Stromal Microenvironment 

      McKay, Tina B; Hjortdal, Jesper; Sejersen, Henrik; Asara, John M; Wu, Jennifer; Karamichos, Dimitrios (Nature Publishing Group, 2016)
      Hormones play a critical role in regulating tissue function by promoting cell survival, proliferation, and differentiation. Our study explores the influence of endocrine function in regulating metabolism and inflammatory ...

    • The Endocrine Tumor Summit 2008: Appraising Therapeutic Approaches for Acromegaly and Carcinoid Syndrome 

      Klibanski, Anne; Melmed, Shlomo; Clemmons, David R.; Colao, Annamaria; Cunningham, Regina S.; Molitch, Mark E.; Vinik, Aaron I.; Adelman, Daphne T.; Liebert, Karen J. P. (Springer US, 2009)
      The Endocrine Tumor Summit convened in December 2008 to address 6 statements prepared by panel members that reflect important questions in the treatment of acromegaly and carcinoid syndrome. Data pertinent to each of the ...

    • Endogenous B Cells Outcompeting Autoreactive Knock-in B Cells in Germinal Centers of Lupus Mice 

      Al Qureshah, Fahd (2016-05-24)
      Systemic lupus erythematosus (SLE) is characterized by the production of autoantibodies against nucleic acid antigens. Despite the recent insight into the pathogenesis of the disease, the exact underlying causes of B cell ...

    • Endogenous Cholinergic Neurotransmission Contributes to Behavioral Sensitization to Morphine 

      Bajic, Dusica; Soiza-Reilly, Mariano; Spalding, Allegra L.; Berde, Charles B.; Commons, Kathryn G. (Public Library of Science, 2015)
      Neuroplasticity in the mesolimbic dopaminergic system is critical for behavioral adaptations associated with opioid reward and addiction. These processes may be influenced by cholinergic transmission arising from the ...

    • Endogenous Levels of Circulating Androgens and Risk of Crohn's Disease and Ulcerative Colitis Among Women: A Nested Case–Control Study from the Nurses' Health Study Cohorts 

      Khalili, Hamed; Ananthakrishnan, Ashwin N.; Konijeti, Gauree G.; Higuchi, Leslie M.; Fuchs, Charles S.; Richter, James M.; Tworoger, Shelley S.; Hankinson, Susan E.; Chan, Andrew T. (Lippincott Williams & Wilkins, 2015)
      Background: Androgens, which are known to be altered by exogenous hormone use, have recently been linked to alterations of the gut microbiome and mucosal immune function. No study has evaluated the association between ...

    • Endogenous sex steroids in premenopausal women and risk of breast cancer: the ORDET cohort 

      Schernhammer, Eva S; Sperati, Francesca; Razavi, Pedram; Agnoli, Claudia; Sieri, Sabina; Berrino, Franco; Krogh, Vittorio; Abbagnato, Carlo Alberto; Grioni, Sara; Blandino, Giovanni; Schunemann, Holger J; Muti, Paola (BioMed Central, 2013)
      Introduction: Previous studies showed that higher testosterone levels are associated with greater risk of breast cancer in premenopausal women, but the literature is scant and inconsistent. Methods: In a prospective nested ...

    • An Endogenous Small Interfering RNA Pathway in Drosophila 

      Czech, Benjamin; Malone, Colin D.; Zhou, Rui; Stark, Alexander; Schlingeheyde, Catherine; Dus, Monica; Perrimon, Norbert; Kellis, Manolis; Wohlschlegel, James A.; Sachidanandam, Ravi; Hannon, Gregory J.; Brennecke, Julius (Springer Science and Business Media LLC, 2008-06-05)
      Drosophila endogenous small RNAs are categorized according to their mechanisms of biogenesis and the Argonaute protein to which they bind. MicroRNAs are a class of ubiquitously expressed RNAs of approximately 22 nucleotides ...

    • Endogenous tissue plasminogen activator and risk of recurrent cardiac events after an acute coronary syndrome in the MIRACL study 

      Kinlay, Scott; Schwartz, Gregory Richard; Olsson, Anders G.; Rifai, Nader; Bao, Weihang; Libby, Peter; Ganz, Peter (Elsevier BV, 2009)
      Objective To examine the relationship of baseline tissue plasminogen activator (t-PA) to early cardiovascular risk after an acute coronary syndrome, and the effect of intensive statin therapy. Methods We measured ...

    • Endogenous transmembrane protein UT2 inhibits pSTAT3 and suppresses hematological malignancy 

      Lee, Dongjun; Wang, Ying-Hua; Kalaitzidis, Demetrios; Ramachandran, Janani; Eda, Homare; Sykes, David Brian; Raje, Noopur; Scadden, David Thomas (American Society for Clinical Investigation, 2016)
      Regulation of STAT3 activation is critical for normal and malignant hematopoietic cell proliferation. Here, we have reported that the endogenous transmembrane protein upstream-of-mTORC2 (UT2) negatively regulates activation ...

    • Endogenous VEGF Is Required for Visual Function: Evidence for a Survival Role on Müller Cells and Photoreceptors 

      Saint-Geniez, Magali; Maharaj, Arindel S. R.; Walshe, Tony E.; Tucker, Budd A.; Sekiyama, Eiichi; Kurihara, Tomoki; Darland, Diane C.; Young, Michael J.; D'Amore, Patricia Ann (Public Library of Science (PLoS), 2008)
      Background Vascular endothelial growth factor (VEGF) is well known for its role in normal and pathologic neovascularization. However, a growing body of evidence indicates that VEGF also acts on non-vascular cells, both ...

    • Endogenously Generated Omega‐3 Fatty Acids Attenuate Vascular Inflammation and Neointimal Hyperplasia by Interaction With Free Fatty Acid Receptor 4 in Mice 

      Li, Xinzhi; Ballantyne, Laurel L.; Che, Xinghui; Mewburn, Jeffrey D.; Kang, Jing X.; Barkley, Robert M.; Murphy, Robert C.; Yu, Ying; Funk, Colin D. (Blackwell Publishing Ltd, 2015)
      Background: Omega‐3 polyunsaturated fatty acids (ω3 PUFAs) suppress inflammation through activation of free fatty acid receptor 4 (FFAR4), but this pathway has not been explored in the context of cardiovascular disease. ...

    • Endoglin regulates mural cell adhesion in the circulatory system 

      Rossi, Elisa; Smadja, David M.; Boscolo, Elisa; Langa, Carmen; Arevalo, Miguel A.; Pericacho, Miguel; Gamella-Pozuelo, Luis; Kauskot, Alexandre; Botella, Luisa M.; Gaussem, Pascale; Bischoff, Joyce; Lopez-Novoa, José M.; Bernabeu, Carmelo (Springer International Publishing, 2015)
      The circulatory system is walled off by different cell types, including vascular mural cells and podocytes. The interaction and interplay between endothelial cells (ECs) and mural cells, such as vascular smooth muscle cells ...

    • Endometrial Intraepithelial Neoplasia Clinical Correlates and Outcomes 

      Semere, Luwam G.; Ko, Emily; Johnson, Natasha R; Vitonis, Allison F.; Phang, Laura J.; Cramer, Daniel William; Mutter, George L. (Ovid Technologies (Wolters Kluwer Health), 2011)
      Objective To estimate cancer outcome and outcome predictors of women with endometrial intraepithelial neoplasia (EIN). Methods Outcomes of women with first diagnosis of EIN (“index biopsy”) was determined by ...

    • Endometrial stromal beta-catenin is required for steroid-dependent mesenchymal-epithelial cross talk and decidualization 

      Zhang, Ling; Patterson, Amanda L; Zhang, Lihua; Teixeira, Jose M.; Pru, James K (BioMed Central, 2012)
      Background: Beta-catenin is part of a protein complex associated with adherens junctions. When allowed to accumulate to sufficient levels in its dephosphorylated form, beta-catenin serves as a transcriptional co-activator ...

    • Endometriosis mimicking colonic stromal tumor 

      Wadhwa, Vaibhav; Slattery, Eoin; Garud, Sagar; Sethi, Saurabh; Wang, Helen; Poylin, Vitaliy Y.; Berzin, Tyler M. (Oxford University Press, 2015)
      Endometriosis is defined as the presence of endometrial glands and stroma at extra-uterine sites; it is a common disease affecting women of reproductive age. Endometrial tissue can implant itself to various organs, including ...

    • Endometriosis-Associated Ovarian Cancer: A Review of Pathogenesis 

      Worley, Michael Joe; Welch, William Robert; Berkowitz, Ross Stuart; Ng, Shu-Wing (Molecular Diversity Preservation International (MDPI), 2013)
      Endometriosis is classically defined as the presence of endometrial glands and stroma outside of the endometrial lining and uterine musculature. With an estimated frequency of 5%–10% among women of reproductive age, ...