Search
Now showing items 271-277 of 277
Intravital imaging of cardiac function at the single-cell level
(National Academy of Sciences, 2014)
Knowledge of cardiomyocyte biology is limited by the lack of methods to interrogate single-cell physiology in vivo. Here we show that contracting myocytes can indeed be imaged with optical microscopy at high temporal and ...
Digital diffraction analysis enables low-cost molecular diagnostics on a smartphone
(National Academy of Sciences, 2015)
The widespread distribution of smartphones, with their integrated sensors and communication capabilities, makes them an ideal platform for point-of-care (POC) diagnosis, especially in resource-limited settings. Molecular ...
Imaging Macrophage and Hematopoietic Progenitor Proliferation in Atherosclerosis
(American Heart Association, 2015)
Rationale: Local plaque macrophage proliferation and monocyte production in hematopoietic organs promote progression of atherosclerosis. Therefore, noninvasive imaging of proliferation could serve as a biomarker and monitor ...
Label-free detection and molecular profiling of exosomes with a nano-plasmonic sensor
(Nature Research, 2014)
Exosomes show potential for cancer diagnostics because they transport molecular contents of the cells from which they originate. Detection and molecular profiling of exosomes is technically challenging and often requires ...
In Vivo Imaging of Multidrug Resistance Using a Third Generation MDR1 Inhibitor
(American Chemical Society, 2014)
Cellular up-regulation of multidrug resistance protein 1 (MDR1) is a common cause for resistance to chemotherapy; development of third generation MDR1 inhibitors several of which contain a common 6,7-dimethoxy-2-phenethy ...
Fluorescence Endoscopy of Cathepsin Activity Discriminates Dysplasia from Colitis
(Oxford University Press, 2013)
Background:Surveillance colonoscopy using random biopsies to detect colitis-associated cancer (CAC) suffers from poor sensitivity. Although chromoendoscopy improves detection, acceptance in the community has been slow. ...
Recruited macrophages elicit atrial fibrillation
Atrial fibrillation disrupts contraction of the atria, leading to stroke and heart failure. We here decipher how immune and stromal cells contribute to atrial fibrillation. Single-cell transcriptomes from human atria ...