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Visualization and tracking of tumour extracellular vesicle delivery and RNA translation using multiplexed reporters
(Nature Pub. Group, 2015)
Accurate spatiotemporal assessment of extracellular vesicle (EV) delivery and cargo RNA translation requires specific and robust live-cell imaging technologies. Here we engineer optical reporters to label multiple EV ...
Engineered Trehalose Permeable to Mammalian Cells
(Public Library of Science, 2015)
Trehalose is a naturally occurring disaccharide which is associated with extraordinary stress-tolerance capacity in certain species of unicellular and multicellular organisms. In mammalian cells, presence of intra- and ...
New techniques for motion-artifact-free in vivo cardiac microscopy
(Frontiers Media S.A., 2015)
Intravital imaging microscopy (i.e., imaging in live animals at microscopic resolution) has become an indispensable tool for studying the cellular micro-dynamics in cancer, immunology and neurobiology. High spatial and ...
Quantitative Analysis of Chemotherapeutic Effects in Tumors Using In Vivo Staining and Correlative Histology
(IOS Press, 2005)
Aims: To microscopically analyze the chemotherapeutic response of tumors using in vivo staining based on an annexinV-Cy5.5 probe and independently asses their apoptotic count using quantitative histological analysis. ...
Chip-based analysis of exosomal mRNA mediating drug resistance in glioblastoma
(Nature Pub. Group, 2015)
Real-time monitoring of drug efficacy in glioblastoma multiforme (GBM) is a major clinical problem as serial re-biopsy of primary tumours is often not a clinical option. MGMT (O6-methylguanine DNA methyltransferase) and ...
Single cell resolution in vivo imaging of DNA damage following PARP inhibition
(Nature Publishing Group, 2015)
Targeting DNA repair pathways is a powerful strategy to treat cancers. To gauge efficacy in vivo, typical response markers include late stage effects such as tumor shrinkage, progression free survival, or invasive repeat ...
In vivo cell cycle profiling in xenograft tumors by quantitative intravital microscopy
(2015)
Quantification of cell-cycle state at a single-cell level is essential to understand fundamental three-dimensional biological processes such as tissue development and cancer. Analysis of 3D in vivo images, however, is very ...
Multimodal targeted high relaxivity thermosensitive liposome for in vivo imaging
(Nature Publishing Group, 2015)
Liposomes are spherical, self-closed structures formed by lipid bilayers that can encapsulate drugs and/or imaging agents in their hydrophilic core or within their membrane moiety, making them suitable delivery vehicles. ...
On Chip Analysis of CNS Lymphoma in Cerebrospinal Fluid
(Ivyspring International Publisher, 2015)
Molecular profiling of central nervous system lymphomas in cerebrospinal fluid (CSF) samples can be challenging due to the paucicellular and limited nature of the samples. Presented herein is a microfluidic platform for ...
Pleural innate response activator B cells protect against pneumonia via a GM-CSF-IgM axis
(The Rockefeller University Press, 2014)
Pneumonia is a major cause of mortality worldwide and a serious problem in critical care medicine, but the immunophysiological processes that confer either protection or morbidity are not completely understood. We show ...