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Bioorthogonal Small Molecule Imaging Agents Allow Single-Cell Imaging of MET
(Public Library of Science, 2013)
The hepatocyte growth factor receptor (MET) is a receptor tyrosine kinase (RTK) that has emerged as an important cancer target. Consequently, a number of different inhibitors varying in specificity are currently in clinical ...
Local proliferation dominates lesional macrophage accumulation in atherosclerosis
(2013)
During the inflammatory response that drives atherogenesis, macrophages accumulate progressively in the expanding arterial wall1,2. The observation that circulating monocytes give rise to lesional macrophages3–9 has ...
Pharmacokinetics of Natural and Engineered Secreted Factors Delivered by Mesenchymal Stromal Cells
(Public Library of Science, 2014)
Transient cell therapy is an emerging drug class that requires new approaches for pharmacological monitoring during use. Human mesenchymal stem cells (MSCs) are a clinically-tested transient cell therapeutic that naturally ...
Upconverting Organic Dye Doped Core-Shell Nano-Composites for Dual-Modality NIR Imaging and Photo-Thermal Therapy
(Ivyspring International Publisher, 2013)
Nanotechnology approaches offer the potential for creating new optical imaging agents with unique properties that enable uses such as combined molecular imaging and photo-thermal therapy. Ideal preparations should fluoresce ...
Single Cell Analysis of Drug Distribution by Intravital Imaging
(Public Library of Science, 2013)
Recent advances in the field of intravital imaging have for the first time allowed us to conduct pharmacokinetic and pharmacodynamic studies at the single cell level in live animal models. Due to these advances, there is ...
Single cell imaging of Bruton's Tyrosine Kinase using an irreversible inhibitor
(Nature Publishing Group, 2014)
A number of Bruton's tyrosine kinase (BTK) inhibitors are currently in development, yet it has been difficult to visualize BTK expression and pharmacological inhibition in vivo in real time. We synthesized a fluorescent, ...
Automated motion artifact removal for intravital microscopy, without a priori information
(Nature Publishing Group, 2014)
Intravital fluorescence microscopy, through extended penetration depth and imaging resolution, provides the ability to image at cellular and subcellular resolution in live animals, presenting an opportunity for new insights ...
Does FXIII Deficiency Impair Wound Healing after Myocardial Infarction?
(Public Library of Science, 2006)
Inadequate healing of myocardial infarction may contribute to local expansion of the infarct, frequently leading to chamber dilation, heart failure, or myocardial rupture. Experimental evidence in mouse models suggests ...
In Vivo Tomographic Imaging of Red-Shifted Fluorescent Proteins
(Optical Society of America, 2011)
We have developed a spectral inversion method for three-dimensional tomography of far-red and near-infrared fluorescent proteins in animals. The method was developed in particular to address the steep light absorption ...
Magnetic Nanoparticles and MicroNMR for Diagnostic Applications
(Ivyspring International Publisher, 2012)
Sensitive and quantitative measurements of clinically relevant protein biomarkers, pathogens and cells in biological samples would be invaluable for disease diagnosis, monitoring of malignancy, and for evaluating therapy ...