Search
Now showing items 1-10 of 131
Chronic Dry Eye Disease is Principally Mediated by Effector Memory Th17 Cells
(2013)
Recent experimental and clinical data suggest that there is a link between dry eye disease (DED) and T cell-mediated immunity. However, whether these immune responses are a consequence or cause of ocular surface inflammation ...
Expression of the chemokine decoy receptor D6 mediates dendritic cell function and promotes corneal allograft rejection
(Molecular Vision, 2013)
Purpose To identify the role of chemokine receptor 6 (D6) expression by dendritic cells (DCs) and its role in corneal transplant immunity. Methods: Flow cytometry analysis was used to assess the expression level of the D6 ...
International Chronic Ocular Graft-vs-Host-Disease (GVHD) Consensus Group: Proposed Diagnostic Criteria for Chronic GVHD (Part I)
(Nature Publishing Group, 2013)
The International Chronic Ocular GVHD Consensus Group held 4 working meetings to define new diagnostic metrics for chronic ocular graft-versus-host disease (GVHD). After considering the factors currently used to diagnose ...
Involvement of Corneal Lymphangiogenesis in a Mouse Model of Allergic Eye Disease
(Association for Research in Vision and Ophthalmology (ARVO), 2015)
Purpose.
The contribution of lymphangiogenesis (LA) to allergy has received considerable attention and therapeutic inhibition of this process via targeting VEGF has been considered. Likewise, certain inflammatory settings ...
Alteration of Galectin-3 in Tears of Patients With Dry Eye Disease
(Elsevier BV, 2015)
Purpose
To investigate the expression, release, and proteolytic degradation of galectin-3 in patients with dry eye disease.
Design
Observational case series with a comparison group.
Methods
Tear washes and ...
Alloimmunity and Tolerance in Corneal Transplantation
(The American Association of Immunologists, 2016)
Corneal transplantation is one of the most prevalent and successful forms of solid tissue transplantation. Despite favorable outcomes, immune-mediated graft rejection still remains the major cause of corneal allograft ...
Prevalence of ocular hypertension and glaucoma in patients with chronic ocular graft-versus-host disease
(Springer Nature, 2016)
Purpose: To compare densities of corneal epithelial dendritic cells (DCs), corneal subbasal nerves, and conjunctival epithelial immune cells (EICs) between patients with dry eye disease (DED) with and without graft-versus-host ...
Expression of Toll-Like Receptor 4 Contributes to Corneal Inflammation in Experimental Dry Eye Disease
(Association for Research in Vision and Ophthalmology (ARVO), 2012)
Purpose.
To investigate the corneal expression of toll-like receptor (TLR) 4 and determine its contribution to the immunopathogenesis of dry eye disease (DED).
Methods.
Seven to 8-week-old female C57BL/6 mice were ...
Change in Prostaglandin Expression Levels and Synthesizing Activities in Dry Eye Disease
(Elsevier BV, 2012)
Objective
To investigate the expression level of prostaglandins (PGs) and their de novo synthesis in dry eye (DE) disease.
Design
Cross-sectional case-control study and in vivo mouse experimental study.
Parti ...
In Vivo Expansion of Regulatory T Cells by Low-Dose Interleukin-2 Treatment Increases Allograft Survival in Corneal Transplantation
(Ovid Technologies (Wolters Kluwer Health), 2016)
Background
Corneal allograft survival dramatically decreases in hosts with inflamed or vascularized recipient beds. We have previously shown that in rejected corneal allografts regulatory T cells (Tregs) demonstrate ...