Browsing HMS Scholarly Articles by Author "Rüegg, Markus A."
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The TSC-mTOR Pathway Mediates Translational Activation of TOP mRNAs by Insulin Largely in a Raptor- or Rictor-Independent Manner
Patursky-Polischuk, Ilona; Stolovich-Rain, Miri; Hausner-Hanochi, Mirito; Kasir, Judith; Cybulski, Nadine; Avruch, Joseph; Rüegg, Markus A.; Hall, Michael N.; Meyuhas, Oded (American Society for Microbiology, 2009)The stimulatory effect of insulin on protein synthesis is due to its ability to activate various translation factors. We now show that insulin can increase protein synthesis capacity also by translational activation of TOP ...