Browsing HMS Scholarly Articles by Author "Bleecker, Eugene R."

Now showing items 1-12 of 12

    • Airway Lipoxin A4 Generation and Lipoxin A4 Receptor Expression Are Decreased in Severe Asthma 

      Planaguma, Anna; Kazani, Shamsah; Marigowda, Gautham; Haworth, Oliver; Mariani, Thomas J.; Israel, Elliot; Bleecker, Eugene R.; Curran-Everett, Douglas; Erzurum, Serpil C.; Calhoun, William J.; Castro, Mario; Chung, Kian Fan; Gaston, Benjamin M.; Jarjour, Nizar N.; Busse, William W.; Wenzel, Sally E.; Levy, Bruce (American Thoracic Society, 2008-09-15)
      Rationale: Airway inflammation is common in severe asthma despite antiinflammatory therapy with corticosteroids. Lipoxin A4 (LXA4) is an arachidonic acid–derived mediator that serves as an agonist for resolution of ...

    • Assessment of asthma control and asthma exacerbations in the epidemiology and natural history of asthma: outcomes and treatment regimens (TENOR) observational cohort 

      Chipps, Bradley E.; Zeiger, Robert S.; Dorenbaum, Alejandro; Borish, Larry; Wenzel, Sally E.; Miller, Dave P.; Hayden, Mary Lou; Bleecker, Eugene R.; Simons, F. Estelle R.; Szefler, Stanley J.; Weiss, Scott Tillman; Haselkorn, Tmirah (Current Science Inc., 2012)
      Patients with severe or difficult-to-treat asthma account for substantial asthma morbidity, mortality, and healthcare burden despite comprising only a small proportion of the total asthma population. TENOR, a multicenter, ...

    • Asthma Is More Severe in Older Adults 

      Zein, Joe G.; Dweik, Raed A.; Comhair, Suzy A.; Bleecker, Eugene R.; Moore, Wendy C.; Peters, Stephen P.; Busse, William W.; Jarjour, Nizar N.; Calhoun, William J.; Castro, Mario; Chung, K. Fan; Fitzpatrick, Anne; Israel, Elliot; Teague, W. Gerald; Wenzel, Sally E.; Love, Thomas E.; Gaston, Benjamin M.; Erzurum, Serpil C. (Public Library of Science, 2015)
      Background: Severe asthma occurs more often in older adult patients. We hypothesized that the greater risk for severe asthma in older individuals is due to aging, and is independent of asthma duration. Methods: This is a ...

    • Characterization of Factors Associated With Systemic Corticosteroid Use in Severe Asthma: Data From the Severe Asthma Research Program 

      Wysocki, Kenneth; Park, Seo Young; Bleecker, Eugene R.; Busse, William; Castro, Mario; Chung, Kian Fan; Gaston, Benjamin M.; Erzurum, Serpil C.; Israel, Elliot; Teague, W. Gerald; Moore, Charity G.; Wenzel, Sally E. (Elsevier BV, 2014-03)
      Background Exhaled nitric oxide (FeNO) associates with asthma and eosinophilic inflammation. However, relationships between nitric oxide synthases, arginase, FeNO, asthma severity and inflammation remain poorly ...

    • Clinical Implications of Having Reduced Mid Forced Expiratory Flow Rates (FEF25-75), Independently of FEV1, in Adult Patients with Asthma 

      Riley, Craig M.; Wenzel, Sally E.; Castro, Mario; Erzurum, Serpil C.; Chung, Kian Fan; Fitzpatrick, Anne M.; Gaston, Benjamin; Israel, Elliot; Moore, Wendy C.; Bleecker, Eugene R.; Calhoun, William J.; Jarjour, Nizar N.; Busse, William W.; Peters, Stephen P.; Teague, W. Gerald; Sorkness, Ronald; Holguin, Fernando (Public Library of Science (PLoS), 2015-12-30)
      Introduction FEF25-75 is one of the standard results provided in spirometry reports; however, in adult asthmatics there is limited information on how this physiological measure relates to clinical or biological outcomes ...

    • Common Genetic Polymorphisms Influence Blood Biomarker Measurements in COPD 

      Sun, Wei; Kechris, Katerina; Jacobson, Sean; Drummond, M. Bradley; Hawkins, Gregory A.; Yang, Jenny; Chen, Ting-huei; Quibrera, Pedro Miguel; Anderson, Wayne; Barr, R. Graham; Basta, Patricia V.; Bleecker, Eugene R.; Beaty, Terri; Casaburi, Richard; Castaldi, Peter; Cho, Michael H.; Comellas, Alejandro; Crapo, James D.; Criner, Gerard; Demeo, Dawn; Christenson, Stephanie A.; Couper, David J.; Curtis, Jeffrey L.; Doerschuk, Claire M.; Freeman, Christine M.; Gouskova, Natalia A.; Han, MeiLan K.; Hanania, Nicola A.; Hansel, Nadia N.; Hersh, Craig P.; Hoffman, Eric A.; Kaner, Robert J.; Kanner, Richard E.; Kleerup, Eric C.; Lutz, Sharon; Martinez, Fernando J.; Meyers, Deborah A.; Peters, Stephen P.; Regan, Elizabeth A.; Rennard, Stephen I.; Scholand, Mary Beth; Silverman, Edwin K.; Woodruff, Prescott G.; O’Neal, Wanda K.; Bowler, Russell P. (Public Library of Science, 2016)
      Implementing precision medicine for complex diseases such as chronic obstructive lung disease (COPD) will require extensive use of biomarkers and an in-depth understanding of how genetic, epigenetic, and environmental ...

    • Effect of Rare Variants in ADRB2 on Risk of Severe Exacerbations and Symptom Control During Longacting β Agonist Treatment in a Multiethnic Asthma Population: A Genetic Study 

      Ortega, Victor E.; Hawkins, Gregory A.; Moore, Wendy C.; Hastie, Annette T.; Ampleford, Elizabeth J.; Busse, William W.; Castro, Mario; Chardon, Domingo; Erzurum, Serpil C.; Israel, Elliot; Montealegre, Federico; Wenzel, Sally E.; Peters, Stephen P.; Meyers, Deborah A.; Bleecker, Eugene R. (Elsevier BV, 2014-03)
      Background Severe adverse life-threatening events associated with long-acting beta agonists (LABA) use have caused the FDA to review LABA safety which has resulted in a boxed warning and a mandatory LABA safety study in ...

    • Effect of β2-Adrenergic Receptor Polymorphism on Response to Longacting β2 Agonist in Asthma (LARGE Trial): A Genotype-Stratified, Randomised, Placebo-Controlled, Crossover Trial 

      Wechsler, Michael; Kunselman, Susan J.; Chinchilli, Vernon M.; Bleecker, Eugene R.; Boushey, Homer A.; Calhoun, William J.; Ameredes, Bill T.; Castro, Mario; Craig, Timothy J.; Denlinger, Loren; Fahy, John V.; Jarjour, Nizar; Kazani, Shamsah; Kim, Sophia; Kraft, Monica; Lazarus, Stephen C.; Lemanske, Robert F.; Markezich, Amy; Martin, Richard J.; Permaul, Perdita; Peters, Stephen P.; Ramsdell, Joe; Sorkness, Christine A.; Sutherland, E. Rand; Szefler, Stanley J.; Walter, Michael J.; Wasserman, Stephen I.; Israel, Elliot (Elsevier BV, 2009-11-21)
      Background Combined long-acting β2-agonist and inhaled corticosteroid (LABA/ICS) therapy improves outcomes in many asthmatics. Some studies suggest that patients homozygous for arginine at the 16th amino-acid position of ...

    • Genome-Wide Association Analysis in Asthma Subjects Identifies SPATS2L as a Novel Bronchodilator Response Gene 

      Himes, Blanca Elena; Jiang, Xiaofeng; Hu, Ruoxi; Wu, Ann Chen; Su, Jessica Ann Lasky; Klanderman, Barbara J.; Ziniti, John; Senter-Sylvia, Jody; Lima, John J.; Irvin, Charles G.; Peters, Stephen P.; Meyers, Deborah A.; Bleecker, Eugene R.; Kubo, Michiaki; Tamari, Mayumi; Nakamura, Yusuke; Szefler, Stanley J.; Lemanske, Robert F.; Zeiger, Robert S.; Strunk, Robert C.; Martinez, Fernando D.; Hanrahan, John P.; Koppelman, Gerard H.; Postma, Dirkje S.; Nieuwenhuis, Maartje A. E.; Vonk, Judith M.; Panettieri, Reynold A.; Markezich, Amy; Israel, Elliot; Carey, Vincent James; Tantisira, Kelan; Litonjua, Augusto Ampil; Lu, Quan; Weiss, Scott Tillman (Public Library of Science, 2012)
      Bronchodilator response (BDR) is an important asthma phenotype that measures reversibility of airway obstruction by comparing lung function (i.e. FEV1) before and after the administration of a short-acting β2-agonist, the ...

    • Impact of Age and Sex on Outcomes and Hospital Cost of Acute Asthma in the United States, 2011-2012 

      Zein, Joe G.; Udeh, Belinda L.; Teague, W. Gerald; Koroukian, Siran M.; Schlitz, Nicholas K.; Bleecker, Eugene R.; Busse, William B.; Calhoun, William J.; Castro, Mario; Comhair, Suzy A.; Fitzpatrick, Anne M.; Israel, Elliot; Wenzel, Sally E.; Holguin, Fernando; Gaston, Benjamin M.; Erzurum, Serpil C. (Public Library of Science, 2016)
      Background: Worldwide, asthma is a leading cause of morbidity, mortality and economic burden, with significant gender and racial disparities. However, little attention has been given to the independent role of age on ...

    • Integration of Mouse and Human Genome-Wide Association Data Identifies KCNIP4 as an Asthma Gene 

      Sheppard, Keith; Berndt, Annerose; Leme, Adriana S.; Myers, Rachel A.; Gignoux, Christopher R.; Gauderman, W. James; Yang, James J.; Mathias, Rasika A.; Romieu, Isabelle; Torgerson, Dara G.; Roth, Lindsey A.; Huntsman, Scott; Eng, Celeste; Klanderman, Barbara; Ziniti, John; Senter-Sylvia, Jody; Szefler, Stanley J.; Lemanske, Robert F.; Zeiger, Robert S.; Strunk, Robert C.; Martinez, Fernando D.; Boushey, Homer; Chinchilli, Vernon M.; Mauger, David; Koppelman, Gerard H.; Postma, Dirkje S.; Nieuwenhuis, Maartje A. E.; Vonk, Judith M.; Lima, John J.; Irvin, Charles G.; Peters, Stephen P.; Kubo, Michiaki; Tamari, Mayumi; Nakamura, Yusuke; Bleecker, Eugene R.; Meyers, Deborah A.; London, Stephanie J.; Gilliland, Frank D.; Burchard, Esteban G.; Nicolae, Dan L.; Ober, Carole; Paigen, Beverly; Churchill, Gary; Himes, Blanca Elena; Levin, Albert M.; Israel, Elliot; Litonjua, Augusto Ampil; Tantisira, Kelan; Raby, Benjamin Alexander; Barnes, Kathleen C.; Williams, L. Keoki; Demeo, Dawn Lisa; Silverman, Edwin Kepner; Shapiro, Steve D.; Weiss, Scott Tillman (Public Library of Science, 2013)
      Asthma is a common chronic respiratory disease characterized by airway hyperresponsiveness (AHR). The genetics of asthma have been widely studied in mouse and human, and homologous genomic regions have been associated with ...

    • Plasma Interleukin-6 Concentrations, Metabolic Dysfunction, and Asthma Severity: A Cross-Sectional Analysis of Two Cohorts 

      Peters, Michael C; McGrath, Kelly Wong; Hawkins, Gregory A.; Hastie, Annette T; Levy, Bruce; Israel, Elliot; Phillips, Brenda R; Mauger, David T; Comhair, Suzy A.; Erzurum, Serpil C.; Johansson, Mats W.; Jarjour, Nizar N.; Coverstone, Andrea M; Castro, Mario; Holguin, Fernando; Wenzel, Sally E.; Woodruff, Prescott G.; Bleecker, Eugene R.; Fahy, John V (Elsevier BV, 2016-07-01)
      Background Severe asthma is a complex heterogeneous disease associated with older age and obesity. The presence of eosinophilic (type 2) inflammation in some but not all patients with severe asthma predicts responsiveness ...