Browsing HMS Scholarly Articles by Author "Liu, Xia"

Now showing items 1-9 of 9

    • Blockade of Glioma Proliferation through Allosteric Inhibition of JAK2 

      He, Kunyan; Qi, Qi; Chan, Chi-Bun; Xiao, Ge; Liu, Xia; Tucker-Burden, Carol; Wang, Liya; Mao, Hui; Lu, Xiang; McDonald, Frank E.; Luo, Hongbo; Fan, Qi-Wen; Weiss, William A.; Sun, Shi-Yong; Brat, Daniel J.; Ye, Keqiang (American Association for the Advancement of Science (AAAS), 2013)
      The gene that encodes the epidermal growth factor receptor (EGFR) is frequently overexpressed or mutated in human cancers, including glioblastoma. However, the efficacy of EGFR-targeted small-molecule inhibitors or monoclonal ...

    • Clonal Architecture of CXCR4 WHIM-Like Mutations in Waldenström Macroglobulinaemia 

      Xu, Lian; Hunter, Zachary; Tsakmaklis, Nicholas; Cao, Yang; Yang, Guang; Chen, Jie; Liu, Xia; Kanan, Sandra; Castillo, Jorge; Tai, Yu-Tzu; Zehnder, James L.; Brown, Jennifer; Carrasco, Ruben; Advani, Ranjana; Sabile, Jean M.; Argyropoulos, Kimon; Lia Palomba, M.; Morra, Enrica; Trojani, Alessandra; Greco, Antonino; Tedeschi, Alessandra; Varettoni, Marzia; Arcaini, Luca; Munshi, Nikhil; Anderson, Kenneth; Treon, Steven (Wiley, 2016-03)
      CXCR4WHIM somatic mutations are distinctive to Waldenstrom Macroglobulinaemia (WM), and impact disease presentation and treatment outcome. The clonal architecture of CXCR4WHIM mutations remains to be delineated. We developed ...

    • Deficiency of Phosphoinositide 3-Kinase Enhancer Protects Mice From Diet-Induced Obesity and Insulin Resistance 

      Chan, Chi Bun; Liu, Xia; Jung, Dae Young; Jun, John Y.; Luo, Hongbo; Kim, Jason K.; Ye, Keqiang (American Diabetes Association, 2010)
      OBJECTIVE: Phosphoinositide 3-kinase enhancer A (PIKE-A) is a proto-oncogene that promotes tumor growth and transformation by enhancing Akt activity. However, the physiological functions of PIKE-A in peripheral tissues are ...

    • Direct Interaction between AR and PAK6 in Androgen-Stimulated PAK6 Activation 

      Liu, Xia; Busby, Jennifer; John, Ciny; Wei, Jianning; Yuan, Xin; Lu, Michael L. (Public Library of Science, 2013)
      A p21-activated kinase 6 (PAK6) was previously identified to be an androgen receptor (AR) interacting protein through a yeast two-hybrid screening. We used hormone responsive prostate cancer LAPC4 and LNCap cell lines as ...

    • Identification of a Molecular Activator for Insulin Receptor with Potent Anti-Diabetic Effects 

      He, Kunyan; Chan, Chi-Bun; Liu, Xia; Jia, Yonghui; Luo, Hongbo; France, Stefan A.; Liu, Yang; Wilson, W. David; Ye, Keqiang (American Society for Biochemistry & Molecular Biology (ASBMB), 2011)
      Insulin exerts its actions through the insulin receptor (IR) and plays an essential role in diabetes. The inconvenient daily injection and undesirable side-effects associated with insulin injection demand novel drugs for ...

    • Neuroprotective Actions of PIKE-L by Inhibition of SET Proteolytic Degradation by Asparagine Endopeptidase 

      Liu, Zhixue; Jang, Sung-Wuk; Liu, Xia; Cheng, Dongmei; Peng, Junmin; Yepes, Manuel; Li, Xiao-jiang; Matthews, Steve; Watts, Colin; Asano, Masahide; Hara-Nishimura, Ikuko; Luo, Hongbo; Ye, Keqiang (Elsevier BV, 2008)
      Ischemia and seizure cause excessive neuronal excitation that is associated with brain acidosis and neuronal cell death. However, the molecular mechanism of acidification-triggered neuronal injury is incompletely understood. ...

    • Optimization of a Small Tropomyosin-Related Kinase B (TrkB) Agonist 7,8-Dihydroxyflavone Active in Mouse Models of Depression 

      Liu, Xia; Chan, Chi-Bun; Qi, Qi; Xiao, Ge; Luo, Hongbo; He, Xiaolin; Ye, Keqiang (American Chemical Society (ACS), 2012)
      Structure–activity relationship study shows that the catechol group in 7,8-dihdyroxyflavone, a selective small TrkB receptor agonist, is critical for agonistic activity. To improve the poor pharmacokinetic profiles intrinsic ...

    • Phosphoinositide 3-Kinase Enhancer Regulates Neuronal Dendritogenesis and Survival in Neocortex 

      Bun Chan, Chi; Liu, Xia; Pradoldej, Sompol; Hao, Chunhai; An, Jie; Yepes, Manuel; Luo, Hongbo; Ye, Keqiang (Society for Neuroscience, 2011)
      Phosphoinositide 3-kinase enhancer (PIKE) binds and enhances phosphatidylinositol 3-kinase (PI3K)/Akt activities. However, its physiological functions in brain have never been explored. Here we show that PIKE is important ...

    • A Synthetic 7,8-Dihydroxyflavone Derivative Promotes Neurogenesis and Exhibits Potent Antidepressant Effect 

      Liu, Xia; Chan, Chi-Bun; Jang, Sung-Wuk; Pradoldej, Sompol; Huang, Junjian; He, Kunyan; Phun, Lien H.; France, Stefan; Xiao, Ge; Jia, Yonghui; Luo, Hongbo; Ye, Keqiang (American Chemical Society (ACS), 2010)
      7,8-Dihydroxyflavone is a recently identified small molecular tropomyosin-receptor-kinase B (TrkB) agonist. Our preliminary structural−activity relationship (SAR) study showed that the 7,8-dihydroxy groups are essential ...