Browsing HMS Scholarly Articles by Author "Borrell, Andrew"
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Widespread Sequence Variations in VAMP1 across Vertebrates Suggest a Potential Selective Pressure from Botulinum Neurotoxins
Peng, Lisheng; Adler, Michael; Demogines, Ann; Borrell, Andrew; Liu, Huisheng; Tao, Liang; Tepp, William H.; Zhang, Su-Chun; Johnson, Eric A.; Sawyer, Sara L.; Dong, Min (Public Library of Science, 2014)Botulinum neurotoxins (BoNT/A-G), the most potent toxins known, act by cleaving three SNARE proteins required for synaptic vesicle exocytosis. Previous studies on BoNTs have generally utilized the major SNARE homologues ...