Browsing HMS Scholarly Articles by Author "Tyo, Keith"

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    • Measuring Cation Dependent DNA Polymerase Fidelity Landscapes by Deep Sequencing 

      Zamft, Bradley; Marblestone, Adam Henry; Kording, Konrad; Schmidt, Daniel; Martin-Alarcon, Daniel; Tyo, Keith; Boyden, Edward S.; Church, George McDonald (Public Library of Science, 2012)
      High-throughput recording of signals embedded within inaccessible micro-environments is a technological challenge. The ideal recording device would be a nanoscale machine capable of quantitatively transducing a wide range ...

    • Statistical Analysis of Molecular Signal Recording 

      Glaser, Joshua I.; Zamft, Bradley M.; Marblestone, Adam H.; Moffitt, Jeffrey R.; Tyo, Keith; Boyden, Edward S.; Church, George; Kording, Konrad P. (Public Library of Science, 2013)
      A molecular device that records time-varying signals would enable new approaches in neuroscience. We have recently proposed such a device, termed a “molecular ticker tape”, in which an engineered DNA polymerase (DNAP) ...