Browsing HMS Scholarly Articles by Author "Lee, Sang-Kyung"

Now showing items 1-2 of 2

    • NFAT5 Regulates HIV-1 in Primary Monocytes via a Highly Conserved Long Terminal Repeat Site 

      Ranjbar, Shahin; Tsytsykova, Alla V.; Lee, Sang-Kyung; Rajsbaum, Ricardo; Falvo, James V.; Lieberman, Judy; Shankar, Premlata; Goldfeld, Anne E.; Ross, Susan (Public Library of Science, 2006)
      To replicate, HIV-1 capitalizes on endogenous cellular activation pathways resulting in recruitment of key host transcription factors to its viral enhancer. RNA interference has been a powerful tool for blocking key ...

    • Sustained Small Interfering RNA-Mediated Human Immunodeficiency Virus Type 1 Inhibition in Primary Macrophages 

      Song, Erwei; Lee, Sang-Kyung; Dykxhoorn, Derek M.; Novina, Carl; Zhang, Dong; Crawford, Keith; Cerny, Jan; Sharp, Phillip A.; Lieberman, Judy; Manjunath, N.; Shankar, Premlata (American Society for Microbiology, 2003)
      Small interfering RNAs (siRNAs) can induce potent gene silencing by degradation of cognate mRNA. However, in dividing cells, the silencing lasts only 3 to 7 days, presumably because of siRNA dilution with cell division. ...