Browsing HMS Scholarly Articles by Author "Gutierrez, Alejandro"
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Complete hematologic response of early T-cell progenitor acute lymphoblastic leukemia to the γ-secretase inhibitor BMS-906024: genetic and epigenetic findings in an outlier case
Knoechel, Birgit; Bhatt, Ami; Pan, Li; Pedamallu, Chandra S.; Severson, Eric; Gutierrez, Alejandro; Dorfman, David M.; Kuo, Frank C.; Kluk, Michael; Kung, Andrew L.; Zweidler-McKay, Patrick; Meyerson, Matthew; Blacklow, Stephen C.; DeAngelo, Daniel J.; Aster, Jon C. (Cold Spring Harbor Laboratory Press, 2015)Notch pathway antagonists such as γ-secretase inhibitors (GSIs) are being tested in diverse cancers, but exceptional responses have yet to be reported. We describe the case of a patient with relapsed/refractory early T-cell ...