Browsing HMS Scholarly Articles by Author "Borre, Pierre Vanden"
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Combined BRAFV600E- and SRC-inhibition induces apoptosis, evokes an immune response and reduces tumor growth in an immunocompetent orthotopic mouse model of anaplastic thyroid cancer
Borre, Pierre Vanden; Gunda, Viswanath; McFadden, David G.; Sadow, Peter M.; Varmeh, Shohreh; Bernasconi, Maria; Parangi, Sareh (Impact Journals LLC, 2014)Anaplastic (ATC) and refractory papillary thyroid cancer (PTC) lack effective treatments. Inhibition of either oncogenic BRAF or SRC has marked anti-tumor effects in mouse models of thyroid cancer, however, neither drug ... -
Combining BRAF inhibitor and anti PD-L1 antibody dramatically improves tumor regression and anti tumor immunity in an immunocompetent murine model of anaplastic thyroid cancer
Brauner, Eran; Gunda, Viswanath; Borre, Pierre Vanden; Zurakowski, David; Kim, Yon Seon; Dennett, Kate Virginia; Amin, Salma; Freeman, Gordon James; Parangi, Sareh (Impact Journals LLC, 2016)The interaction of programmed cell death-1 and its ligand is widely studied in cancer. Monoclonal antibodies blocking these molecules have had great success but little is known about them in thyroid cancer. We investigated ...