Browsing HMS Scholarly Articles by Title
Now showing items 14811-14830 of 17937
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A Role of Three-Dimensional (3D)-Reconstruction in the Classification of Lung Adenocarcinoma
(IOS Press, 2012)Background:: Three-dimensional (3D)-reconstruction from paraffin embedded sections has been considered laborious and time-consuming. However, the high-resolution images of large object areas and different fields of view ... -
The Role of TNF-\(\alpha\) in Mice with Type 1- and 2- Diabetes
(Public Library of Science, 2012)Background: Previously, we have demonstrated that short-term treatment of new onset diabetic Non-obese diabetic (NOD) mice, mice that are afflicted with both type 1 (T1D) and type 2 (T2D) diabetes with either Power Mix ... -
The Role of Tobacco, Alcohol, and Obesity in Neoplastic Progression to Esophageal Adenocarcinoma: A Prospective Study of Barrett's Esophagus
(Public Library of Science, 2013)Background: Esophageal adenocarcinoma (EA) incidence in many developed countries has increased dramatically over four decades, while survival remains poor. Persons with Barrett's esophagus (BE), who experience substantially ... -
The Role of Transcription Factors at Antisense-Expressing Gene Pairs in Yeast
(Oxford University Press, 2016)Genes encoded close to one another on the chromosome are often coexpressed, by a mechanism and regulatory logic that remain poorly understood. We surveyed the yeast genome for tandem gene pairs oriented tail-to-head at ... -
The role of TRIM24 during prostate cancer progression
(BioMed Central, 2013) -
The role of tumor metabolism as a driver of prostate cancer progression and lethal disease: results from a nested case-control study
(BioMed Central, 2016)Background: Understanding the biologic mechanisms underlying the development of lethal prostate cancer is critical for improved therapeutic and prevention strategies. In this study we explored the role of tumor metabolism ... -
The Role of Ultrasound in Diagnosis of the Causes of Low Back Pain: a Review of the Literature
(Kowsar, 2015)Context: Low back pain (LBP) is among the most prevalent musculoskeletal conditions in the developed countries. It is a common problem causing disability and imposing a huge economic burden to individuals and state ... -
Role of vascular density and normalization in response to neoadjuvant bevacizumab and chemotherapy in breast cancer patients
(National Academy of Sciences, 2015)Preoperative bevacizumab and chemotherapy may benefit a subset of breast cancer (BC) patients. To explore potential mechanisms of this benefit, we conducted a phase II study of neoadjuvant bevacizumab (single dose) followed ... -
Role of Wall Teichoic Acids in Staphylococcus aureus Endophthalmitis
(Association for Research in Vision and Ophthalmology (ARVO), 2011)Purpose: Wall teichoic acids (WTAs) are major polyanionic polymer components of the cell wall of Staphylococcus aureus. However, little is known about their role at the host–pathogen interface, especially in endophthalmitis. ... -
The role of whole brain radiation therapy in the management of melanoma brain metastases
(BioMed Central, 2014)Background: Brain metastases are common in patients with melanoma, and optimal management is not well defined. As melanoma has traditionally been thought of as “radioresistant,” the role of whole brain radiation therapy ... -
The Role Played by Cell-Substrate Interactions in the Pathogenesis of Osteoclast-Mediated Peri-Implant Osteolysis
(BioMed Central, 2006)Prosthetic wear debris-induced peri-implant osteolysis is a major cause of aseptic loosening after total joint replacement. In this condition, wear particles released from the implant components induce a granulomatous ... -
Roles for the Conserved Spc105p/Kre28p Complex in Kinetochore-Microtubule Binding and the Spindle Assembly Checkpoint
(Public Library of Science, 2009)Background: Kinetochores attach sister chromatids to microtubules of the mitotic spindle and orchestrate chromosome disjunction at anaphase. Although S. cerevisiae has the simplest known kinetochores, they nonetheless ... -
Roles for VEGF in the adult
(Elsevier BV, 2007)The role of VEGF during development and in pathology is well known, but its function in normal adult tissues is poorly understood. Adverse effects associated with the use of anti-angiogenic therapies targeting VEGF in human ... -
The roles of long noncoding RNA in epigenetic regulation
(BioMed Central, 2013) -
Roles of Major Facilitator Superfamily Transporters in Phosphate Response in \(Drosophila\)
(Public Library of Science, 2012)The major facilitator superfamily (MFS) transporter \(Pho84\) and the type III transporter \(Pho84\) are responsible for metabolic effects of inorganic phosphate in yeast. While the \(Pho84\) ortholog Pit1 was also shown ... -
Roles of Nurse Practitioners and Physician Assistants in Rheumatology Practices in the US
(Wiley-Blackwell, 2014)Background—A recent workforce study of rheumatology in the US suggests that during the next several decades the demand for rheumatology services will outstrip the supply of rheumatologists. Mid-level providers such as nurse ... -
Roles of Piwi Proteins in Transcriptional Regulation Mediated by HP1s in Cultured Silkworm Cells
(Public Library of Science, 2014)Piwi proteins are part of a superfamily of Argonaute proteins, which are one of the core components of the RNA silencing pathway in many eukaryotes. Piwi proteins are thought to repress the transposon expression both ... -
The roles of senior management in improving hospital experiences for frail older adults
(Cengage Learning, Inc., 2006) -
The Roles of Streptozotocin Neurotoxicity and Neutral Endopeptidase in Murine Experimental Diabetic Neuropathy
(Hindawi Publishing Corporation, 2009)We demonstrated that inhibition of neutral endopeptidase (NEP), a protease that degrades vaso- and neuroactive peptides, improves vascular and neural function in diabetic animal models. In this study we explored the role ... -
Roles of the Nuclear Lamina in Stable Nuclear Association and Assembly of a Herpesviral Transactivator Complex on Viral Immediate-Early Genes
(American Society for Microbiology, 2012)ABSTRACT: Little is known about the mechanisms of gene targeting within the nucleus and its effect on gene expression, but most studies have concluded that genes located near the nuclear periphery are silenced by ...