Browsing HMS Scholarly Articles by Title
Now showing items 14409-14428 of 17922
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Requirements for the Formation of Membrane Pores by the Reovirus Myristoylated μ1N Peptide
(American Society for Microbiology, 2009) -
Rescue and repair during photoreceptor cell renewal mediated by docosahexaenoic acid-derived neuroprotectin D1
(American Society for Biochemistry and Molecular Biology, 2010)Retinal degenerative diseases result in retinal pigment epithelial (RPE) and photoreceptor cell loss. These cells are continuously exposed to the environment (light) and to potentially pro-oxidative conditions, as the ... -
Rescue of Bacteriophage T7 DNA Polymerase of Low Processivity by Suppressor Mutations Affecting Gene 3 Endonuclease
(American Society for Microbiology, 2009)The DNA polymerase encoded by gene 5 (gp5) of bacteriophage T7 has low processivity, dissociating after the incorporation of a few nucleotides. Upon binding to its processivity factor, Escherichia coli thioredoxin (Trx), ... -
Rescue of DNA-PK Signaling and T-Cell Differentiation by Targeted Genome Editing in a prkdc Deficient iPSC Disease Model
(Public Library of Science, 2015)In vitro disease modeling based on induced pluripotent stem cells (iPSCs) provides a powerful system to study cellular pathophysiology, especially in combination with targeted genome editing and protocols to differentiate ... -
RESCUE OF HIPPO CO-ACTIVATOR YAP1 TRIGGERS DNA DAMAGE-INDUCED APOPTOSIS IN HEMATOLOGICAL CANCERS
(2014)Oncogene–induced DNA damage elicits genomic instability in epithelial cancer cells, but apoptosis is blocked through inactivation of the tumor suppressor p53. In hematological cancers, the relevance of ongoing DNA damage ... -
Rescue of neonatal cardiac dysfunction in mice by administration of cardiac progenitor cells in utero
(Nature Pub. Group, 2015)Striated preferentially expressed gene (Speg) is a member of the myosin light chain kinase family. We previously showed that disruption of the Speg gene locus in mice leads to a dilated cardiomyopathy with immature-appearing ... -
Rescue Strategies for Refractory Hypoxemia: A Critical Appraisal
(Medicine Reports Ltd, 2009)Mechanical ventilation is the most important aspect of supportive care of patients with severe acute respiratory failure. Most research directed to improving the prognosis of these patients has focused on improving support ... -
A Research Algorithm to Improve Detection of Delirium in the Intensive Care Unit
(BioMed Central, 2006)Introduction: Delirium is a serious and prevalent problem in intensive care units (ICUs). The purpose of this study was to develop a research algorithm to enhance detection of delirium in critically ill ICU patients using ... -
Research on the Premotor Symptoms of Parkinson’s Disease: Clinical and Etiological Implications
(National Institute of Environmental Health Sciences, 2013)Background: The etiology and natural history of Parkinson’s disease (PD) are not well understood. Some non-motor symptoms such as hyposmia, rapid eye movement sleep behavior disorder, and constipation may develop during ... -
Research Resources: Curating the New Eagle-I Discovery System
(Oxford University Press, 2012)Development of biocuration processes and guidelines for new data types or projects is a challenging task. Each project finds its way toward defining annotation standards and ensuring data consistency with varying degrees ... -
Research, Collaboration, and Open Science Using Web 2.0
(American Society for Microbiology, 2010-12)There is little doubt that the Internet has transformed the world in which we live. Information that was once archived in bricks and mortar libraries is now only a click away, and people across the globe have become connected ... -
Resection of Acquired Mucosal Web in Crohn Disease
(Ovid Technologies (Wolters Kluwer Health), 2013) -
Resection of the Liver for Colorectal Carcinoma Metastases A Multi-institutional Study of Long-term Survivors
(1988)In this review of a collected series of patients undergoing hepatic resection for colorectal metastases, 100 patients were found to have survived greater than five years from the time of resection. Of these 100 long-term ... -
Resection of the liver for colorectal carcinoma metastases: A multi-institutional study of indications for resection
(Elsevier, 1988)In an investigation of the indications for hepatic resection in the treatment of colorectal carcinoma metastases, the records of 859 patients who had undergone this procedure were reviewed. This patient group, from 24 ... -
Reserve and Reserve-building activities research: key challenges and future directions
(BioMed Central, 2016)Background: The concept of Cognitive Reserve has great appeal and has led to an interesting and important body of research. We believe, however, that it is unnecessarily limited by ‘habits’ of measurement, nomenclature, ... -
Reshaping the brain: direct lineage conversion in the nervous system
(Faculty of 1000 Ltd, 2013)During embryonic development, cells in an uncommitted pluripotent state undergo progressive epigenetic changes that lock them into a final restrictive differentiated state. However, recent advances have shown that not only ... -
Residential Black Carbon Exposure and Circulating Markers of Systemic Inflammation in Elderly Males: The Normative Aging Study
(National Institute of Environmental Health Sciences, 2012)Background: Traffic-related particles (TRPs) are associated with adverse cardiovascular events. The exact mechanisms are unclear, but systemic inflammatory responses likely play a role. Objectives: We conducted a repeated ... -
Residential Exposure to Traffic-Related Air Pollution and Survival after Heart Failure
(National Institute of Environmental Health Sciences, 2008)Background: Although patients with heart failure (HF) have been identified as particularly susceptible to the acute effects of air pollution, the effects of long-term exposure to air pollution on patients with this ... -
Residual Complexes Containing SMARCA2 (BRM) Underlie the Oncogenic Drive of SMARCA4 (BRG1) Mutation
(American Society for Microbiology, 2014)Collectively, genes encoding subunits of the SWI/SNF (BAF) chromatin remodeling complex are mutated in 20% of all human cancers, with the SMARCA4 (BRG1) subunit being one of the most frequently mutated. The SWI/SNF complex ... -
Residual macrovascular risk in 2013: what have we learned?
(BioMed Central, 2014)Cardiovascular disease poses a major challenge for the 21st century, exacerbated by the pandemics of obesity, metabolic syndrome and type 2 diabetes. While best standards of care, including high-dose statins, can ameliorate ...