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Obesity and Life Expectancy with and without Diabetes in Adults Aged 55 Years and Older in the Netherlands: A Prospective Cohort Study
(Public Library of Science, 2016)
Background: Overweight and obesity are associated with increased risk of type 2 diabetes. Limited evidence exists regarding the effect of excess weight on years lived with and without diabetes. We aimed to determine the ...
Novel Genetic Variants for Cartilage Thickness and Hip Osteoarthritis
(Public Library of Science, 2016)
Osteoarthritis is one of the most frequent and disabling diseases of the elderly. Only few genetic variants have been identified for osteoarthritis, which is partly due to large phenotype heterogeneity. To reduce heterogeneity, ...
Orthostatic Hypotension and the Long-Term Risk of Dementia: A Population-Based Study
(Public Library of Science, 2016)
Background: Orthostatic hypotension (OH) is a common cause of transient cerebral hypoperfusion in the population. Cerebral hypoperfusion is widely implicated in cognitive impairment, but whether OH contributes to cognitive ...
Metabolically Healthy Obesity and the Risk of Cardiovascular Disease in the Elderly Population
(Public Library of Science, 2016)
Background: Whether being metabolically healthy obese (MHO)—defined by the presence of obesity in the absence of metabolic syndrome—is associated with subsequent cardiovascular disease (CVD) remains unclear and may depend ...