Different behavioral effects of neurotoxic dorsal hippocampal lesions placed under either isoflurane or propofol anesthesia

DSpace/Manakin Repository

Different behavioral effects of neurotoxic dorsal hippocampal lesions placed under either isoflurane or propofol anesthesia

Show simple item record

dc.contributor.author Baxter, Mark G
dc.contributor.author Murphy, Kathy L
dc.contributor.author Crosby, Gregory
dc.contributor.author Culley, Deborah Jean
dc.date.accessioned 2011-04-29T01:22:04Z
dc.date.issued 2007
dc.identifier.citation Baxter, Mark G., Kathy L. Murphy, Gregory Crosby, and Deborah J. Culley. 2008. Different behavioral effects of neurotoxic dorsal hippocampal lesions placed under either isoflurane or propofol anesthesia. Hippocampus 18(3): 245-250. en_US
dc.identifier.issn 1050-9631 en_US
dc.identifier.uri http://nrs.harvard.edu/urn-3:HUL.InstRepos:4879192
dc.description.abstract Anesthetic protocols for behavioral neuroscience experiments are evolving as new anesthetics are developed and surgical procedures are refined to improve animal welfare. We tested whether neurotoxic dorsal hippocampal lesions produced under two different anesthetic protocols would have different behavioral and/or histo-pathological effects. Rats were anesthetized with either propofol, an intravenous anesthetic, or isoflurane, a gaseous anesthetic, and multiple injections of an excitotoxin (N-methyl-d-aspartate) were stereotaxically placed in the dorsal hippocampus bilaterally. Intraoperative physiological parameters were similar in the two surgical groups, as were the volumes of the lesions, although the profile of postoperative impairment in a spatial learning task differed between the lesion groups depending on the anesthetic regimen used. These results show that the choice of anesthetic protocol is a critical variable in designing behavioral neuroscience experiments using neurosurgical procedures. This factor should be considered carefully in experimental design and in cross-study comparisons of lesion effects on behavior. en_US
dc.language.iso en_US en_US
dc.publisher Wiley Subscription Services, Inc., A Wiley Company en_US
dc.relation.isversionof doi:10.1002/hipo.20390 en_US
dc.relation.hasversion http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2386959/pdf/ en_US
dash.license LAA
dc.subject life and medical sciences en_US
dc.subject neuroscience, neurology and psychiatry en_US
dc.subject hippocampus en_US
dc.subject spatial memory en_US
dc.subject learning en_US
dc.subject surgery en_US
dc.subject refinement en_US
dc.title Different behavioral effects of neurotoxic dorsal hippocampal lesions placed under either isoflurane or propofol anesthesia en_US
dc.type Journal Article en_US
dc.description.version Version of Record en_US
dc.relation.journal Hippocampus en_US
dash.depositing.author Culley, Deborah Jean
dc.date.available 2011-04-29T01:22:04Z
dash.affiliation.other HMS^Anaesthesia-Brigham and Women's Hospital en_US

Files in this item

Files Size Format View
2386959.pdf 276.3Kb PDF View/Open

This item appears in the following Collection(s)

Show simple item record

 
 

Search DASH


Advanced Search
 
 

Submitters