Genome-Wide Expression Profiling of Five Mouse Models Identifies Similarities and Differences with Human Psoriasis
View/ Open
Author
Johnston, Andrew
Carbajal, Steve
Han, Gangwen
Wohn, Christian
Lu, Jun
Xing, Xianying
Nair, Rajan P.
Voorhees, John J.
Elder, James T.
Wang, Xiao-Jing
Sano, Shigetoshi
Prens, Errol P.
DiGiovanni, John
Pittelkow, Mark R.
Ward, Nicole L.
Gudjonsson, Johann E.
Note: Order does not necessarily reflect citation order of authors.
Published Version
https://doi.org/10.1371/journal.pone.0018266Metadata
Show full item recordCitation
Swindell, William R., Andrew Johnston, Steve Carbajal, Gangwen Han, Christian Wohn, Jun Lu, Xianying Xing, et al. 2011. Genome-wide expression profiling of five mouse models identifies similarities and differences with human psoriasis. PLoS ONE 6(4): e18266Abstract
Development of a suitable mouse model would facilitate the investigation of pathomechanisms underlying human psoriasis and would also assist in development of therapeutic treatments. However, while many psoriasis mouse models have been proposed, no single model recapitulates all features of the human disease, and standardized validation criteria for psoriasis mouse models have not been widely applied. In this study, whole-genome transcriptional profiling is used to compare gene expression patterns manifested by human psoriatic skin lesions with those that occur in five psoriasis mouse models (K5-Tie2, imiquimod, K14-AREG, K5-Stat3C and K5-TGFbeta1). While the cutaneous gene expression profiles associated with each mouse phenotype exhibited statistically significant similarity to the expression profile of psoriasis in humans, each model displayed distinctive sets of similarities and differences in comparison to human psoriasis. For all five models, correspondence to the human disease was strong with respect to genes involved in epidermal development and keratinization. Immune and inflammation-associated gene expression, in contrast, was more variable between models as compared to the human disease. These findings support the value of all five models as research tools, each with identifiable areas of convergence to and divergence from the human disease. Additionally, the approach used in this paper provides an objective and quantitative method for evaluation of proposed mouse models of psoriasis, which can be strategically applied in future studies to score strengths of mouse phenotypes relative to specific aspects of human psoriasis.Other Sources
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3070727/pdf/Terms of Use
This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAACitable link to this page
http://nrs.harvard.edu/urn-3:HUL.InstRepos:5110312
Collections
- HMS Scholarly Articles [17922]
Contact administrator regarding this item (to report mistakes or request changes)