Browsing by Author "Dulac, Catherine"

Now showing items 1-17 of 17

    • Convergent Excitatory Pathways Mediate the Zebrafish Escape Behavior 

      Lacoste, Alix Mary Bénédicte (2015-05-14)
      Scientists have long been fascinated by how anatomical structures in the brain can generate the diversity of behaviors apparent in the animal kingdom. While the ultimate goal of neuroscience is to understand complex brain ...

    • The Discovery and Characterization of the lncRNA Firre 

      Hacisuleyman, Fatma Ezgi (2015-05-08)
      RNAs, including long noncoding RNAs (lncRNA), are known to be abundant and important structural components of the nuclear infrastructure. Yet, the identities, functional roles, and localization dynamics of lncRNAs that ...

    • Expression of Candidate Pheromone Receptor Genes in Vomeronasal Neurons 

      Axel, R.; Dulac, Catherine (Oxford University Press (OUP), 1998-08-01)
      In mammals, olfactory sensory perception is mediated by two anatomically and functionally distinct organs: the main olfactory epithelium (MOE) and the vomeronasal organ (VON). Pheromones activate the VNO and elicit a ...

    • Functional circuit architecture underlying parental behaviour 

      Kohl, Johannes; Babayan, Benedicte M.; Rubinstein, Nimrod D.; Autry, Anita; Marin-Rodriguez, Brenda; Kapoor, Vikrant; Miyamishi, Kazunari; Zweifel, Larry S.; Luo, Liqun; Uchida, Naoshige; Dulac, Catherine (Springer Science and Business Media LLC, 2018-04)
      Parenting is essential for the survival and wellbeing of mammalian offspring but we lack a circuit-level understanding of how distinct components of this behaviour are orchestrated. Here we investigate how Galanin-expressing ...

    • Galanin neurons in the medial preoptic area govern parental behavior 

      Wu, Zheng; Autry, Anita E.; Bergan, Joseph F.; Watabe-Uchida, Mitsuko; Dulac, Catherine G. (2014)
      Mice display robust, stereotyped behaviors toward pups: virgin males typically attack pups, while virgin females and sexually experienced males and females display parental care. We show here that virgin males genetically ...

    • Histone variants and cellular plasticity 

      Santoro, Stephen W; Dulac, Catherine (Elsevier BV, 2015-09)
      The broad diversity of cell types within vertebrates arises from a unique genetic blueprint by combining intrinsic cellular information with developmental and other extrinsic signals. Lying at the interface between cellular ...

    • Identification of a Signaling Network in Lateral Nucleus of Amygdala Important for Inhibiting Memory Specifically Related to Learned Fear 

      Shumyatsky, Gleb P.; Tsvetkov, Evgeny; Malleret, Gaël; Vronskaya, Svetlana; Hatton, Michael; Hampton, Lori; Battey, James F.; Dulac, Catherine; Kandel, Eric R.; Bolshakov, Vadim Y. (Elsevier BV, 2002-12)
      We identified the Grp gene, encoding gastrin-releasing peptide, as being highly expressed both in the lateral nucleus of the amygdala, the nucleus where associations for Pavlovian learned fear are formed, and in the regions ...

    • Mapping of Brain Activity by Automated Volume Analysis of Immediate Early Genes 

      Renier, Nicolas; Adams, Eliza L.; Kirst, Christoph; Wu, Zhuhao; Azevedo, Ricardo; Kohl, Johannes; Kadiri, Lolahon; Umadevi Venkataraju, Kannan; Zhou, Yu; Wang, Victoria X.; Tang, Cheuk Y.; Olsen, Olav; Dulac, Catherine; Osten, Pavel; Tessier-Lavigne, Marc; Autry, Anita (Elsevier BV, 2016-06)
      Understanding how neural information is processed in physiological and pathological states would benefit from precise detection, localization, and quantification of the activity of all neurons across the entire brain, which ...

    • The Molecular Determinants of Cranial Skeletal Development and Evolution 

      Namkoong, Bumjin (2015-10-01)
      The vertebrate head and face, one of the defining features of vertebrates, is an evolutionary novelty that enabled the major radiation of Vertebrata. The emergence of the multipotent neural crest cells, often mentioned as ...

    • Molecular, Spatial, and Functional Single-Cell Profiling of the Hypothalamic Preoptic Region 

      Moffitt, Jeffrey; Bambah-Mukku, Dhananjay; Eichhorn, Stephen W.; Vaughn, Eric; Shekhar, Karthik; Perez, Julio D.; Rubinstein, Nimrod D.; Hao, Junjie; Regev, Aviv; Dulac, Catherine; Zhuang, Xiaowei (American Association for the Advancement of Science (AAAS), 2018-11-16)
      The hypothalamus controls essential social behaviors and homeostatic functions. However, the cellular architecture of hypothalamic nuclei, including the molecular identity, spatial organization, and function of distinct ...

    • The Neurobiology of Parenting: A Neural Circuit Perspective 

      Kohl, Johannes; Dulac, Catherine; Autry, Anita (Wiley, 2016-12-06)
      Social interactions are essential for animals to reproduce, defend their territory, and raise their young. The conserved nature of social behaviors across animal species suggests that the neural pathways underlying the ...

    • Neuronal Representation of Social Information in the Medial Amygdala of Awake Behaving Mice 

      Li, Ying; Mathis, Alexander; Grewe, Benjamin F.; Osterhout, Jessica A.; Ahanonu, Biafra; Schnitzer, Mark J.; Murthy, Venkatesh; Dulac, Catherine (Elsevier BV, 2017-11)
      The medial amygdala (MeA) plays a critical role in processing species- and sex-specific signals that trigger social and defensive behaviors. However, the principles by which this deep brain structure encodes social information ...

    • New Perspectives on Genomic Imprinting, an Essential and Multifaceted Mode of Epigenetic Control in the Developing and Adult Brain 

      Perez, Julio D.; Rubinstein, Nimrod D.; Dulac, Catherine (Annual Reviews, 2016-07-08)
      Mammalian evolution entailed multiple innovations in gene regulation, including the emergence of genomic imprinting, an epigenetic regulation leading to the preferential expression of a gene from its maternal or paternal ...

    • Olfactory Inputs to Hypothalamic Neurons Controlling Reproduction and Fertility 

      Yoon, Hayan; Enquist, L.W.; Dulac, Catherine (Elsevier BV, 2005-11)
      In order to gain insight into sensory processing modulating reproductive behavioral and endocrine changes, we have aimed at identifying afferent pathways to neurons synthesizing luteinizing hormone-releasing hormone (LHRH, ...

    • Quantitative and functional interrogation of parent-of-origin allelic expression biases in the brain 

      Perez, Julio D; Rubinstein, Nimrod D; Fernandez, Daniel E; Santoro, Stephen W; Needleman, Leigh A; Ho-Shing, Olivia; Choi, John J; Zirlinger, Mariela; Chen, Shau-Kwaun; Liu, Jun S; Dulac, Catherine (eLife Sciences Publications, Ltd, 2015)
      The maternal and paternal genomes play different roles in mammalian brains as a result of genomic imprinting, an epigenetic regulation leading to differential expression of the parental alleles of some genes. Here we ...

    • Sex separation induces differences in the olfactory sensory receptor repertoires of male and female mice 

      van der Linden, Carl; Jakob, Susanne; Gupta, Pooja; Dulac, Catherine; Santoro, Stephen W. (Springer Science and Business Media LLC, 2018-12)
      Within the mammalian olfactory sensory epithelium, experience-dependent changes in the rate of neuronal turnover can alter the relative abundance of neurons expressing specific chemoreceptors. Here we investigate how the ...

    • Sex-specific processing of social cues in the medial amygdala 

      Bergan, Joseph F; Ben-Shaul, Yoram; Dulac, Catherine (eLife Sciences Publications, Ltd, 2014)
      Animal–animal recognition within, and across species, is essential for predator avoidance and social interactions. Despite its essential role in orchestrating responses to animal cues, basic principles of information ...