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Gene-Wide Analysis Detects Two New Susceptibility Genes for Alzheimer's Disease

dc.contributor.authorEscott-Price, Valentinaen_US
dc.contributor.authorBellenguez, Célineen_US
dc.contributor.authorWang, Li-Sanen_US
dc.contributor.authorChoi, Seung-Hoanen_US
dc.contributor.authorHarold, Deniseen_US
dc.contributor.authorJones, Lesleyen_US
dc.contributor.authorHolmans, Peteren_US
dc.contributor.authorGerrish, Amyen_US
dc.contributor.authorVedernikov, Alexeyen_US
dc.contributor.authorRichards, Alexanderen_US
dc.contributor.authorDeStefano, Anita L.en_US
dc.contributor.authorLambert, Jean-Charlesen_US
dc.contributor.authorIbrahim-Verbaas, Carla A.en_US
dc.contributor.authorNaj, Adam C.en_US
dc.contributor.authorSims, Rebeccaen_US
dc.contributor.authorJun, Gyungahen_US
dc.contributor.authorBis, Joshua C.en_US
dc.contributor.authorBeecham, Gary W.en_US
dc.contributor.authorGrenier-Boley, Benjaminen_US
dc.contributor.authorRusso, Giancarloen_US
dc.contributor.authorThornton-Wells, Tricia A.en_US
dc.contributor.authorDenning, Nicolaen_US
dc.contributor.authorSmith, Albert V.en_US
dc.contributor.authorChouraki, Vincenten_US
dc.contributor.authorThomas, Charleneen_US
dc.contributor.authorIkram, M. Arfanen_US
dc.contributor.authorZelenika, Dianaen_US
dc.contributor.authorVardarajan, Badri N.en_US
dc.contributor.authorKamatani, Yoichiroen_US
dc.contributor.authorLin, Chiao-Fengen_US
dc.contributor.authorSchmidt, Helenaen_US
dc.contributor.authorKunkle, Brianen_US
dc.contributor.authorDunstan, Melanie L.en_US
dc.contributor.authorVronskaya, Mariaen_US
dc.contributor.authorJohnson, Andrew D.en_US
dc.contributor.authorRuiz, Agustinen_US
dc.contributor.authorBihoreau, Marie-Thérèseen_US
dc.contributor.authorReitz, Christianeen_US
dc.contributor.authorPasquier, Florenceen_US
dc.contributor.authorHollingworth, Paulen_US
dc.contributor.authorHanon, Olivieren_US
dc.contributor.authorFitzpatrick, Annette L.en_US
dc.contributor.authorBuxbaum, Joseph D.en_US
dc.contributor.authorCampion, Dominiqueen_US
dc.contributor.authorCrane, Paul K.en_US
dc.contributor.authorBaldwin, Clintonen_US
dc.contributor.authorBecker, Timen_US
dc.contributor.authorGudnason, Vilmunduren_US
dc.contributor.authorCruchaga, Carlosen_US
dc.contributor.authorCraig, Daviden_US
dc.contributor.authorAmin, Najafen_US
dc.contributor.authorBerr, Claudineen_US
dc.contributor.authorLopez, Oscar L.en_US
dc.contributor.authorDe Jager, Philip L.en_US
dc.contributor.authorDeramecourt, Vincenten_US
dc.contributor.authorJohnston, Janet A.en_US
dc.contributor.authorEvans, Denisen_US
dc.contributor.authorLovestone, Simonen_US
dc.contributor.authorLetenneur, Lucen_US
dc.contributor.authorHernández, Isabelen_US
dc.contributor.authorRubinsztein, David C.en_US
dc.contributor.authorEiriksdottir, Gudnyen_US
dc.contributor.authorSleegers, Kristelen_US
dc.contributor.authorGoate, Alison M.en_US
dc.contributor.authorFiévet, Nathalieen_US
dc.contributor.authorHuentelman, Matthew J.en_US
dc.contributor.authorGill, Michaelen_US
dc.contributor.authorBrown, Kristelleen_US
dc.contributor.authorKamboh, M. Ilyasen_US
dc.contributor.authorKeller, Linaen_US
dc.contributor.authorBarberger-Gateau, Pascaleen_US
dc.contributor.authorMcGuinness, Bernadetteen_US
dc.contributor.authorLarson, Eric B.en_US
dc.contributor.authorMyers, Amanda J.en_US
dc.contributor.authorDufouil, Caroleen_US
dc.contributor.authorTodd, Stephenen_US
dc.contributor.authorWallon, Daviden_US
dc.contributor.authorLove, Sethen_US
dc.contributor.authorRogaeva, Ekaterinaen_US
dc.contributor.authorGallacher, Johnen_US
dc.contributor.authorGeorge-Hyslop, Peter Sten_US
dc.contributor.authorClarimon, Jordien_US
dc.contributor.authorLleo, Albertoen_US
dc.contributor.authorBayer, Anthonyen_US
dc.contributor.authorTsuang, Debby W.en_US
dc.contributor.authorYu, Leien_US
dc.contributor.authorTsolaki, Magdaen_US
dc.contributor.authorBossù, Paolaen_US
dc.contributor.authorSpalletta, Gianfrancoen_US
dc.contributor.authorProitsi, Petraen_US
dc.contributor.authorCollinge, Johnen_US
dc.contributor.authorSorbi, Sandroen_US
dc.contributor.authorGarcia, Florentino Sanchezen_US
dc.contributor.authorFox, Nick C.en_US
dc.contributor.authorHardy, Johnen_US
dc.contributor.authorNaranjo, Maria Candida Denizen_US
dc.contributor.authorBosco, Paoloen_US
dc.contributor.authorClarke, Roberten_US
dc.contributor.authorBrayne, Carolen_US
dc.contributor.authorGalimberti, Danielaen_US
dc.contributor.authorScarpini, Elioen_US
dc.contributor.authorBonuccelli, Ubaldoen_US
dc.contributor.authorMancuso, Michelangeloen_US
dc.contributor.authorSiciliano, Gabrieleen_US
dc.contributor.authorMoebus, Susanneen_US
dc.contributor.authorMecocci, Patriziaen_US
dc.contributor.authorZompo, Maria Delen_US
dc.contributor.authorMaier, Wolfgangen_US
dc.contributor.authorHampel, Haralden_US
dc.contributor.authorPilotto, Albertoen_US
dc.contributor.authorFrank-García, Anaen_US
dc.contributor.authorPanza, Francescoen_US
dc.contributor.authorSolfrizzi, Vincenzoen_US
dc.contributor.authorCaffarra, Paoloen_US
dc.contributor.authorNacmias, Benedettaen_US
dc.contributor.authorPerry, Williamen_US
dc.contributor.authorMayhaus, Manuelen_US
dc.contributor.authorLannfelt, Larsen_US
dc.contributor.authorHakonarson, Hakonen_US
dc.contributor.authorPichler, Sabrinaen_US
dc.contributor.authorCarrasquillo, Minerva M.en_US
dc.contributor.authorIngelsson, Martinen_US
dc.contributor.authorBeekly, Duaneen_US
dc.contributor.authorAlvarez, Victoriaen_US
dc.contributor.authorZou, Fanggengen_US
dc.contributor.authorValladares, Ottoen_US
dc.contributor.authorYounkin, Steven G.en_US
dc.contributor.authorCoto, Elieceren_US
dc.contributor.authorHamilton-Nelson, Kara L.en_US
dc.contributor.authorGu, Weien_US
dc.contributor.authorRazquin, Cristinaen_US
dc.contributor.authorPastor, Pauen_US
dc.contributor.authorMateo, Ignacioen_US
dc.contributor.authorOwen, Michael J.en_US
dc.contributor.authorFaber, Kelley M.en_US
dc.contributor.authorJonsson, Palmi V.en_US
dc.contributor.authorCombarros, Onofreen_US
dc.contributor.authorO'Donovan, Michael C.en_US
dc.contributor.authorCantwell, Laura B.en_US
dc.contributor.authorSoininen, Hilkkaen_US
dc.contributor.authorBlacker, Deborahen_US
dc.contributor.authorMead, Simonen_US
dc.contributor.authorMosley, Thomas H.en_US
dc.contributor.authorBennett, David A.en_US
dc.contributor.authorHarris, Tamara B.en_US
dc.contributor.authorFratiglioni, Lauraen_US
dc.contributor.authorHolmes, Cliveen_US
dc.contributor.authorde Bruijn, Renee F. A. G.en_US
dc.contributor.authorPassmore, Peteren_US
dc.contributor.authorMontine, Thomas J.en_US
dc.contributor.authorBettens, Karolienen_US
dc.contributor.authorRotter, Jerome I.en_US
dc.contributor.authorBrice, Alexisen_US
dc.contributor.authorMorgan, Kevinen_US
dc.contributor.authorForoud, Tatiana M.en_US
dc.contributor.authorKukull, Walter A.en_US
dc.contributor.authorHannequin, Didieren_US
dc.contributor.authorPowell, John F.en_US
dc.contributor.authorNalls, Michael A.en_US
dc.contributor.authorRitchie, Karenen_US
dc.contributor.authorLunetta, Kathryn L.en_US
dc.contributor.authorKauwe, John S. K.en_US
dc.contributor.authorBoerwinkle, Ericen_US
dc.contributor.authorRiemenschneider, Matthiasen_US
dc.contributor.authorBoada, Mercèen_US
dc.contributor.authorHiltunen, Mikkoen_US
dc.contributor.authorMartin, Eden R.en_US
dc.contributor.authorSchmidt, Reinholden_US
dc.contributor.authorRujescu, Danen_US
dc.contributor.authorDartigues, Jean-Françoisen_US
dc.contributor.authorMayeux, Richarden_US
dc.contributor.authorTzourio, Christopheen_US
dc.contributor.authorHofman, Alberten_US
dc.contributor.authorNöthen, Markus M.en_US
dc.contributor.authorGraff, Carolineen_US
dc.contributor.authorPsaty, Bruce M.en_US
dc.contributor.authorHaines, Jonathan L.en_US
dc.contributor.authorLathrop, Marken_US
dc.contributor.authorPericak-Vance, Margaret A.en_US
dc.contributor.authorLauner, Lenore J.en_US
dc.contributor.authorVan Broeckhoven, Christineen_US
dc.contributor.authorFarrer, Lindsay A.en_US
dc.contributor.authorvan Duijn, Cornelia M.en_US
dc.contributor.authorRamirez, Alfredoen_US
dc.contributor.authorSeshadri, Sudhaen_US
dc.contributor.authorSchellenberg, Gerard D.en_US
dc.contributor.authorAmouyel, Philippeen_US
dc.contributor.authorWilliams, Julieen_US
dc.date.accessioned2014-07-07T17:01:50Z
dc.date.issued2014en_US
dc.identifier.citationEscott-Price, V., C. Bellenguez, L. Wang, S. Choi, D. Harold, L. Jones, P. Holmans, et al. 2014. “Gene-Wide Analysis Detects Two New Susceptibility Genes for Alzheimer's Disease.” PLoS ONE 9 (6): e94661. doi:10.1371/journal.pone.0094661. http://dx.doi.org/10.1371/journal.pone.0094661.en
dc.identifier.issn1932-6203en
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:12406561
dc.description.abstractBackground: Alzheimer's disease is a common debilitating dementia with known heritability, for which 20 late onset susceptibility loci have been identified, but more remain to be discovered. This study sought to identify new susceptibility genes, using an alternative gene-wide analytical approach which tests for patterns of association within genes, in the powerful genome-wide association dataset of the International Genomics of Alzheimer's Project Consortium, comprising over 7 m genotypes from 25,580 Alzheimer's cases and 48,466 controls. Principal Findings In addition to earlier reported genes, we detected genome-wide significant loci on chromosomes 8 (TP53INP1, p = 1.4×10−6) and 14 (IGHV1-67 p = 7.9×10−8) which indexed novel susceptibility loci. Significance The additional genes identified in this study, have an array of functions previously implicated in Alzheimer's disease, including aspects of energy metabolism, protein degradation and the immune system and add further weight to these pathways as potential therapeutic targets in Alzheimer's disease.en
dc.language.isoen_USen
dc.publisherPublic Library of Scienceen
dc.relation.isversionofdoi:10.1371/journal.pone.0094661en
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC4055488/pdf/en
dash.licenseLAAen_US
dc.subjectBiology and Life Sciencesen
dc.subjectComputational Biologyen
dc.subjectGenome Analysisen
dc.subjectGenome-Wide Association Studiesen
dc.subjectGeneticsen
dc.subjectHuman Geneticsen
dc.subjectGenetic Association Studiesen
dc.subjectGenomicsen
dc.subjectMedicine and Health Sciencesen
dc.subjectMental Health and Psychiatryen
dc.subjectDementiaen
dc.subjectAlzheimer Diseaseen
dc.subjectNeurologyen
dc.subjectPhysical Sciencesen
dc.subjectMathematicsen
dc.subjectStatistics (Mathematics)en
dc.subjectBiostatisticsen
dc.titleGene-Wide Analysis Detects Two New Susceptibility Genes for Alzheimer's Diseaseen
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden
dc.relation.journalPLoS ONEen
dash.depositing.authorDe Jager, Philip L.en_US
dc.date.available2014-07-07T17:01:50Z
dc.identifier.doi10.1371/journal.pone.0094661*
dash.authorsorderedfalse
dash.contributor.affiliatedDe Jager, Philip
dash.contributor.affiliatedBlacker, Deborah


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