Browsing FAS Scholarly Articles by Title
Now showing items 4163-4182 of 18296
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Domain-selective small-molecule inhibitor of histone deacetylase 6 (HDAC6)-mediated tubulin deacetylation
(National Academy of Sciences, 2003)Protein acetylation, especially histone acetylation, is the subject of both research and clinical investigation. At least four small-molecule histone deacetylase inhibitors are currently in clinical trials for the treatment ... -
Domain-Specific Knowledge Systems in the Brain: The Animate-Inanimate Distinction
(Massachusetts Institute of Technology Press, 1998)We claim that the animate and inanimate conceptual categories represent evolutionarily adapted domain-specific knowledge systems that are subserved by distinct neural mechanisms, thereby allowing for their selective ... -
Domains of depleted mantle: New evidence from hafnium and neodymium isotopes
(Wiley-Blackwell, 2011)Isotope systematics of basalts provide information on the distribution of mantle components and the length scale of mantle heterogeneity. To obtain this information, high data and sampling density are crucial. We present ... -
Domenichino Richard E. Spear
(University of California Press, 1984) -
Domestic Interests and Control Regimes
(Cambridge University Press, 2007) -
The “Domestication Syndrome” in Mammals: A Unified Explanation Based on Neural Crest Cell Behavior and Genetics
(Genetics Society of America, 2014)Charles Darwin, while trying to devise a general theory of heredity from the observations of animal and plant breeders, discovered that domesticated mammals possess a distinctive and unusual suite of heritable traits not ... -
Dominance of one bacterial phylotype at a Mid-Atlantic Ridge hydrothermal vent site.
(Proceedings of the National Academy of Sciences, 1995)Microbial community structure in natural environments has remained largely unexplored yet is generally considered to be complex. It is shown here that in a Mid-Atlantic Ridge hydrothermal vent habitat, where food webs ... -
Don't Take the Premise for Granted: Mitigating Artifacts in Natural Language Inference
(Association of Computational Linguistics, 2019-07)Natural Language Inference (NLI) datasets often contain hypothesis-only biases—artifacts that allow models to achieve non-trivial performance without learning whether a premise entails a hypothesis. We propose two probabilistic ... -
Donald Charles Backer
(American Institute of Physics, 2011) -
Don’t panic: Interpretation bias is predictive of new onsets of panic disorder
(Elsevier BV, 2014)Psychological models of panic disorder postulate that interpretation of ambiguous material as threatening is an important maintaining factor for the disorder. However, demonstrations of whether such a bias predicts onset ... -
Doodle Around the World: Online Scheduling Behavior Reflects Cultural Differences in Time Perception and Group Decision-Making
(ACM Press, 2013)Event scheduling is a group decision-making process in which social dynamics influence people's choices and the overall outcome. As a result, scheduling is not simply a matter of finding a mutually agreeable time, but a ... -
Dopa-Responsive Dystonia: Functional Analysis of Single Nucleotide Substitutions within the 5’ Untranslated GCH1 Region
(Public Library of Science, 2013)Background: Mutations in the GCH1 gene are associated with childhood onset, dopa-responsive dystonia (DRD). Correct diagnosis of DRD is crucial, given the potential for complete recovery once treated with L-dopa. The ... -
Dopamine D1 signaling organizes network dynamics underlying working memory
(American Association for the Advancement of Science, 2016)Local prefrontal dopamine signaling supports working memory by tuning pyramidal neurons to task-relevant stimuli. Enabled by simultaneous positron emission tomography–magnetic resonance imaging (PET-MRI), we determined ... -
Dopamine Genetic Risk Score Predicts Depressive Symptoms in Healthy Adults and Adults with Depression
(Public Library of Science, 2014)Background: Depression is a common source of human disability for which etiologic insights remain limited. Although abnormalities of monoamine neurotransmission, including dopamine, are theorized to contribute to the ... -
Dopamine neurons projecting to the posterior striatum form an anatomically distinct subclass
(eLife Sciences Publications, Ltd, 2015)Combining rabies-virus tracing, optical clearing (CLARITY), and whole-brain light-sheet imaging, we mapped the monosynaptic inputs to midbrain dopamine neurons projecting to different targets (different parts of the striatum, ... -
Dopamine neurons projecting to the posterior striatum form an anatomically distinct subclass
(eLife Sciences Publications, Ltd, 2015)Combining rabies-virus tracing, optical clearing (CLARITY), and whole-brain light-sheet imaging, we mapped the monosynaptic inputs to midbrain dopamine neurons projecting to different targets (different parts of the striatum, ... -
Dopamine neurons share common response function for reward prediction error
(Springer Nature, 2016)Dopamine neurons are thought to signal reward prediction error, or the difference between actual and predicted reward. How dopamine neurons jointly encode this information, however, remains unclear. One possibility is that ... -
Dopamine Signaling Is Essential for Precise Rates of Locomotion by C. elegans
(Public Library of Science, 2012)Dopamine is an important neuromodulator in both vertebrates and invertebrates. We have found that reduced dopamine signaling can cause a distinct abnormality in the behavior of the nematode C. elegans, which has only eight ... -
Dopant activation in Sn-doped Ga2O3 investigated by X-ray absorption spectroscopy
(AIP Publishing, 2015)Doping activity in both beta-phase (β-) and amorphous (a-) Sn-doped gallium oxide (Ga2O3:Sn) is investigated by X-ray absorption spectroscopy(XAS). A single crystal of β-Ga2O3:Sn grown using edge-defined film-fed growth ... -
Dopant clustering, electronic inhomogeneity, and vortex pinning in iron-based superconductors
(American Physical Society (APS), 2013)We use scanning tunneling microscopy to map the surface structure, nanoscale electronic inhomogeneity, and vitreous vortex phase in the hole-doped superconductor Sr0.75K0.25Fe2As2 with Tc=32 K. We find that the low-T cleaved ...