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dc.contributor.authorFranke, Barbaraen_US
dc.contributor.authorStein, Jason Len_US
dc.contributor.authorRipke, Stephanen_US
dc.contributor.authorAnttila, Vernerien_US
dc.contributor.authorHibar, Derrek Pen_US
dc.contributor.authorvan Hulzen, Kimm J Een_US
dc.contributor.authorArias-Vasquez, Alejandroen_US
dc.contributor.authorSmoller, Jordan Wen_US
dc.contributor.authorNichols, Thomas Een_US
dc.contributor.authorNeale, Michael Cen_US
dc.contributor.authorMcIntosh, Andrew Men_US
dc.contributor.authorLee, Philen_US
dc.contributor.authorMcMahon, Francis Jen_US
dc.contributor.authorMeyer-Lindenberg, Andreasen_US
dc.contributor.authorMattheisen, Manuelen_US
dc.contributor.authorAndreassen, Ole Aen_US
dc.contributor.authorGruber, Oliveren_US
dc.contributor.authorSachdev, Perminder Sen_US
dc.contributor.authorRoiz-Santiañez, Robertoen_US
dc.contributor.authorSaykin, Andrew Jen_US
dc.contributor.authorEhrlich, Stefanen_US
dc.contributor.authorMather, Karen Aen_US
dc.contributor.authorTurner, Jessica Aen_US
dc.contributor.authorSchwarz, Emanuelen_US
dc.contributor.authorThalamuthu, Anbupalamen_US
dc.contributor.authorShugart, Yin Yaoen_US
dc.contributor.authorHo, Yvonne YWen_US
dc.contributor.authorMartin, Nicholas Gen_US
dc.contributor.authorWright, Margaret Jen_US
dc.contributor.authorO'Donovan, Michael Cen_US
dc.contributor.authorThompson, Paul Men_US
dc.contributor.authorNeale, Benjamin Men_US
dc.contributor.authorMedland, Sarah Een_US
dc.contributor.authorSullivan, Patrick Fen_US
dc.date.accessioned2016-10-11T20:29:02Z
dc.date.issued2016en_US
dc.identifier.citationFranke, B., J. L. Stein, S. Ripke, V. Anttila, D. P. Hibar, K. J. E. van Hulzen, A. Arias-Vasquez, et al. 2016. “Genetic influences on schizophrenia and subcortical brain volumes: large-scale proof-of-concept and roadmap for future studies.” Nature neuroscience 19 (3): 420-431. doi:10.1038/nn.4228. http://dx.doi.org/10.1038/nn.4228.en
dc.identifier.issn1097-6256en
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:29002734
dc.description.abstractSchizophrenia is a devastating psychiatric illness with high heritability. Brain structure and function differ, on average, between schizophrenia cases and healthy individuals. As common genetic associations are emerging for both schizophrenia and brain imaging phenotypes, we can now use genome-wide data to investigate genetic overlap. Here we integrated results from common variant studies of schizophrenia (33,636 cases, 43,008 controls) and volumes of several (mainly subcortical) brain structures (11,840 subjects). We did not find evidence of genetic overlap between schizophrenia risk and subcortical volume measures either at the level of common variant genetic architecture or for single genetic markers. The current study provides proof-of-concept (albeit based on a limited set of structural brain measures), and defines a roadmap for future studies investigating the genetic covariance between structural/functional brain phenotypes and risk for psychiatric disorders.en
dc.language.isoen_USen
dc.relation.isversionofdoi:10.1038/nn.4228en
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC4852730/pdf/en
dash.licenseLAAen_US
dc.subjectschizophreniaen
dc.subjectMRIen
dc.subjectbrain imagingen
dc.subjectgeneticsen
dc.subjectGWASen
dc.subjectmeta-analysisen
dc.subjectendophenotypeen
dc.titleGenetic influences on schizophrenia and subcortical brain volumes: large-scale proof-of-concept and roadmap for future studiesen
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden
dc.relation.journalNature neuroscienceen
dash.depositing.authorRipke, Stephanen_US
dc.date.available2016-10-11T20:29:02Z
dc.identifier.doi10.1038/nn.4228*
dash.authorsorderedfalse
dash.contributor.affiliatedNeale, Benjamin
dash.contributor.affiliatedRipke, Stephan
dash.contributor.affiliatedLee, Phil
dash.contributor.affiliatedSmoller, Jordan


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