Adjuvant ovarian function suppression and cognitive function in women with breast cancer
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Author
Phillips, Kelly-Anne
Ribi, Karin
Francis, Prudence A
Puglisi, Fabio
Bellet, Meritxell
Spazzapan, Simon
Karlsson, Per
Budman, Daniel R
Zaman, Khalil
Abdi, Ehtesham A
Domchek, Susan M
Feng, Yang
Price, Karen N
Coates, Alan S
Maruff, Paul
Boyle, Frances
Forbes, John F
Ahles, Tim
Fleming, Gini F
Bernhard, Jürg
Note: Order does not necessarily reflect citation order of authors.
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https://doi.org/10.1038/bjc.2016.71Metadata
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Phillips, K., M. M. Regan, K. Ribi, P. A. Francis, F. Puglisi, M. Bellet, S. Spazzapan, et al. 2016. “Adjuvant ovarian function suppression and cognitive function in women with breast cancer.” British Journal of Cancer 114 (9): 956-964. doi:10.1038/bjc.2016.71. http://dx.doi.org/10.1038/bjc.2016.71.Abstract
Background: To examine the effect on cognitive function of adjuvant ovarian function suppression (OFS) for breast cancer. Methods: The Suppression of Ovarian Function (SOFT) trial randomised premenopausal women with hormone receptor-positive breast cancer to 5 years adjuvant endocrine therapy with tamoxifen+OFS, exemestane+OFS or tamoxifen alone. The Co-SOFT substudy assessed objective cognitive function and patient reported outcomes at randomisation (T0), and 1 year later (T1); the primary endpoint was change in global cognitive function, measured by the composite objective cognitive function score. Data were compared for the pooled tamoxifen+OFS and exemestane+OFS groups vs the tamoxifen alone group using the Wilcoxon rank-sum test. Results: Of 86 participants, 74 underwent both T0 and T1 cognitive testing; 54 randomised to OFS+ either tamoxifen (28) or exemestane (26) and 20 randomised to tamoxifen alone. There was no significant difference in the changes in the composite cognitive function scores between the OFS+ tamoxifen or exemestane groups and the tamoxifen group (mean±s.d., −0.21±0.92 vs −0.04±0.49, respectively, P=0.71, effect size=−0.20), regardless of prior chemotherapy status, and adjusting for baseline characteristics. Conclusions: The Co-SOFT study, although limited by small samples size, provides no evidence that adding OFS to adjuvant oral endocrine therapy substantially affects global cognitive function.Other Sources
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4984913/pdf/Terms of Use
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