An Efficient and Practical Radiosynthesis of [11C] Temozolomide

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An Efficient and Practical Radiosynthesis of [11C] Temozolomide

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Title: An Efficient and Practical Radiosynthesis of [11C] Temozolomide
Author: Moseley, Christian K.; Carlin, Stephen M.; Neelamegam, Ramesh; Hooker, Jacob M

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Citation: Moseley, Christian K., Stephen M. Carlin, Ramesh Neelamegam, and Jacob M. Hooker. 2012. “An Efficient and Practical Radiosynthesis of [11C]Temozolomide.” Organic Letters 14 (23) (December 7): 5872–5875. doi:10.1021/ol302791x.
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Abstract: Temozolomide (TMZ) is a prodrug for an alkylating agent used for the treatment of malignant brain tumors. A positron emitting version, [11C]TMZ, has been utilized to help elucidate the mechanism and biodistribution of TMZ. Challenges in [11C]TMZ synthesis and reformulation make it difficult for routine production. A highly reproducible one-pot radiosynthesis of [11C]TMZ with a radiochemical yield of 17 ± 5% and ≥97% radiochemical purity is reported.
Published Version: doi:10.1021/ol302791x
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:33490452
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