| dc.contributor.author | Moseley, Christian K. | |
| dc.contributor.author | Carlin, Stephen M. | |
| dc.contributor.author | Neelamegam, Ramesh | |
| dc.contributor.author | Hooker, Jacob M | |
| dc.date.accessioned | 2017-07-24T17:15:04Z | |
| dc.date.issued | 2012 | |
| dc.identifier.citation | Moseley, Christian K., Stephen M. Carlin, Ramesh Neelamegam, and Jacob M. Hooker. 2012. “An Efficient and Practical Radiosynthesis of [11C]Temozolomide.” Organic Letters 14 (23) (December 7): 5872–5875. doi:10.1021/ol302791x. | en_US |
| dc.identifier.issn | 1523-7060 | en_US |
| dc.identifier.uri | http://nrs.harvard.edu/urn-3:HUL.InstRepos:33490452 | |
| dc.description.abstract | Temozolomide (TMZ) is a prodrug for an alkylating agent used for the treatment of malignant brain tumors. A positron emitting version, [11C]TMZ, has been utilized to help elucidate the mechanism and biodistribution of TMZ. Challenges in [11C]TMZ synthesis and reformulation make it difficult for routine production. A highly reproducible one-pot radiosynthesis of [11C]TMZ with a radiochemical yield of 17 ± 5% and ≥97% radiochemical purity is reported. | en_US |
| dc.description.sponsorship | Chemistry and Chemical Biology | en_US |
| dc.language.iso | en_US | en_US |
| dc.publisher | American Chemical Society (ACS) | en_US |
| dc.relation.isversionof | doi:10.1021/ol302791x | en_US |
| dash.license | META_ONLY | |
| dc.title | An Efficient and Practical Radiosynthesis of [11C] Temozolomide | en_US |
| dc.type | Journal Article | en_US |
| dc.description.version | Version of Record | en_US |
| dc.relation.journal | Organic Letters | en_US |
| dash.depositing.author | Hooker, Jacob M | |
| dash.embargo.until | 10000-01-01 | |
| dc.identifier.doi | 10.1021/ol302791x | * |
| dash.contributor.affiliated | Hooker, Jacob | |
| dash.contributor.affiliated | Neelamegam, Ramesh | |
