dc.contributor.author | McLaren, Paul J | en_US |
dc.contributor.author | Pulit, Sara L | en_US |
dc.contributor.author | Gurdasani, Deepti | en_US |
dc.contributor.author | Bartha, Istvan | en_US |
dc.contributor.author | Shea, Patrick R | en_US |
dc.contributor.author | Pomilla, Cristina | en_US |
dc.contributor.author | Gupta, Namrata | en_US |
dc.contributor.author | Gkrania-Klotsas, Effrossyni | en_US |
dc.contributor.author | Young, Elizabeth H | en_US |
dc.contributor.author | Bannert, Norbert | en_US |
dc.contributor.author | Del Amo, Julia | en_US |
dc.contributor.author | Gill, M John | en_US |
dc.contributor.author | Gilmour, Jill | en_US |
dc.contributor.author | Kellam, Paul | en_US |
dc.contributor.author | Kelleher, Anthony D | en_US |
dc.contributor.author | Sönnerborg, Anders | en_US |
dc.contributor.author | Zangerle, Robert | en_US |
dc.contributor.author | Post, Frank A | en_US |
dc.contributor.author | Fisher, Martin | en_US |
dc.contributor.author | Haas, David W | en_US |
dc.contributor.author | Walker, Bruce D | en_US |
dc.contributor.author | Porter, Kholoud | en_US |
dc.contributor.author | Goldstein, David B | en_US |
dc.contributor.author | Sandhu, Manjinder S | en_US |
dc.contributor.author | de Bakker, Paul I W | en_US |
dc.contributor.author | Fellay, Jacques | en_US |
dc.date.accessioned | 2018-04-19T14:22:35Z | |
dc.date.issued | 2017 | en_US |
dc.identifier.citation | McLaren, P. J., S. L. Pulit, D. Gurdasani, I. Bartha, P. R. Shea, C. Pomilla, N. Gupta, et al. 2017. “Evaluating the Impact of Functional Genetic Variation on HIV-1 Control.” The Journal of Infectious Diseases 216 (9): 1063-1069. doi:10.1093/infdis/jix470. http://dx.doi.org/10.1093/infdis/jix470. | en |
dc.identifier.issn | | en |
dc.identifier.uri | http://nrs.harvard.edu/urn-3:HUL.InstRepos:35982148 | |
dc.description.abstract | Abstract Background: Previous genetic association studies of human immunodeficiency virus-1 (HIV-1) progression have focused on common human genetic variation ascertained through genome-wide genotyping. Methods: We sought to systematically assess the full spectrum of functional variation in protein coding gene regions on HIV-1 progression through exome sequencing of 1327 individuals. Genetic variants were tested individually and in aggregate across genes and gene sets for an influence on HIV-1 viral load. Results: Multiple single variants within the major histocompatibility complex (MHC) region were observed to be strongly associated with HIV-1 outcome, consistent with the known impact of classical HLA alleles. However, no single variant or gene located outside of the MHC region was significantly associated with HIV progression. Set-based association testing focusing on genes identified as being essential for HIV replication in genome-wide small interfering RNA (siRNA) and clustered regularly interspaced short palindromic repeats (CRISPR) studies did not reveal any novel associations. Conclusions: These results suggest that exonic variants with large effect sizes are unlikely to have a major contribution to host control of HIV infection. | en |
dc.language.iso | en_US | en |
dc.publisher | Oxford University Press | en |
dc.relation.isversionof | doi:10.1093/infdis/jix470 | en |
dc.relation.hasversion | http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5853944/pdf/ | en |
dash.license | LAA | en_US |
dc.subject | HIV/AIDS | en |
dc.subject | HIV-1 control | en |
dc.subject | exome sequencing | en |
dc.subject | HIV-1 progression | en |
dc.subject | host genetics of infection | en |
dc.subject | HIV host dependency factors | en |
dc.title | Evaluating the Impact of Functional Genetic Variation on HIV-1 Control | en |
dc.type | Journal Article | en_US |
dc.description.version | Version of Record | en |
dc.relation.journal | The Journal of Infectious Diseases | en |
dash.depositing.author | Walker, Bruce D | en_US |
dc.date.available | 2018-04-19T14:22:35Z | |
dc.identifier.doi | 10.1093/infdis/jix470 | * |
dash.authorsordered | false | |
dash.contributor.affiliated | Walker, Bruce | |
dc.identifier.orcid | 0000-0001-6122-9245 | |