Browsing Harvard Medical School by Title

Now showing items 9979-9998 of 18448

    • Lipocalin 2 expression is associated with aggressive features of endometrial cancer 

      Mannelqvist, Monica; Stefansson, Ingunn M; Wik, Elisabeth; Kusonmano, Kanthida; Raeder, Maria B; Øyan, Anne M; Kalland, Karl-Henning; Moses, Marsha; Salvesen, Helga B; Akslen, Lars A (BioMed Central, 2012)
      Background: Increased expression of lipocalin 2 (LCN2) has been observed in several cancers. The aim of the present study was to investigate LCN2 in endometrial cancer in relation to clinico-pathologic phenotype, angiogenesis, ...

    • Lipochoristoma of the Internal Auditory Canal 

      Scangas, George; Remenschneider, Aaron; Santos, Felipe (Georg Thieme Verlag KG, 2015)
      Objective: Lipochoristomas comprise 0.1% of all cerebellopontine angle tumors and may be misdiagnosed as vestibular schwannomas. We describe a lipochoristoma of the internal auditory canal (IAC) and present the salient ...

    • Lipodystrophy, Diabetes and Normal Serum Insulin in PPARγ-Deficient Neonatal Mice 

      O’Donnell, Peter E.; Ye, Xiu Zhen; DeChellis, Melissa A.; Davis, Vannessa M.; Duan, Sheng Zhong; Mortensen, Richard M.; Milstone, David S. (Public Library of Science, 2016)
      Peroxisome proliferator activated receptor gamma (PPARγ) is a pleiotropic ligand activated transcription factor that acts in several tissues to regulate adipocyte differentiation, lipid metabolism, insulin sensitivity and ...

    • Lipoprotein Lipase Bound to Apolipoprotein B Lipoproteins Accelerates Clearance of Postprandial Lipoproteins in Humans 

      Zheng, Chunyu; Murdoch, Susan J.; Brunzell, John D.; Sacks, Frank (Ovid Technologies (Wolters Kluwer Health), 2006-04)
      Objectives Experiments in cells and animal models show that lipoprotein lipase (LpL) bound to apolipoprotein (apo)B lipoproteins enhances their uptake by receptor mediated pathways. It is unknown whether this pathway is ...

    • Lipoprotein metabolism in nonalcoholic fatty liver disease 

      Jiang, Zhenghui Gordon; Robson, Simon Christopher; Yao, Zemin (Editorial Department of Journal of Biomedical Research, 2013)
      Nonalcoholic fatty liver disease (NAFLD), an escalating health problem worldwide, covers a spectrum of pathologies characterized by fatty accumulation in hepatocytes in early stages, with potential progression to liver ...

    • Lipoprotein particles and size, total and high molecular weight adiponectin, and leptin in relation to incident coronary heart disease among severely obese postmenopausal women: The Women's Health Initiative Observational Study☆☆☆★ 

      Mackey, Rachel H.; McTigue, Kathleen M.; Chang, Yuefang F.; Barinas-Mitchell, Emma; Evans, Rhobert W.; Tinker, Lesley F.; Lewis, Cora E.; Manson, JoAnn E.; Stefanick, Marcia L.; Howard, Barbara V.; Phillips, Lawrence S.; Liu, Simin; Kulick, Doina; Kuller, Lewis H. (Elsevier, 2015)
      Background: We hypothesized that higher concentrations of LDL particles (LDL-P) and leptin, and lower concentrations of HDL particles (HDL-P), and total and high molecular weight (HMW) adiponectin, would predict incident ...

    • Lipoprotein(a) for Risk Assessment in Patients With Established Coronary Artery Disease 

      O, Michelle L.; Morrow, David Andrew; Tsimikas, Sotirios; Sloan, Sarah; Ren, Angela F.; Hoffman, Elaine; Desai, Nihar R.; Solomon, Scott David; Domanski, Michael; Arai, Kiyohito; Chiuve, Stephanie Elizabeth; Cannon, Christopher Paul; Sacks, Frank Martin; Sabatine, Marc Steven (Elsevier BV, 2014)
      OBJECTIVES: The purpose of this study was to assess the prognostic utility of lipoprotein(a) [Lp(a)] in individuals with coronary artery disease (CAD). BACKGROUND: Data regarding an association between Lp(a) and ...

    • Lipoprotein‐Associated Phospholipase A2 Activity Is a Marker of Risk But Not a Useful Target for Treatment in Patients With Stable Coronary Heart Disease 

      Wallentin, Lars; Held, Claes; Armstrong, Paul W.; Cannon, Christopher P.; Davies, Richard Y.; Granger, Christopher B.; Hagström, Emil; Harrington, Robert A.; Hochman, Judith S.; Koenig, Wolfgang; Krug‐Gourley, Sue; Mohler, Emile R.; Siegbahn, Agneta; Tarka, Elizabeth; Steg, Philippe Gabriel; Stewart, Ralph A. H.; Weiss, Robert; Östlund, Ollie; White, Harvey D.; Budaj, Andrzej; Ardissino, Diego; Avezum, Alvaro; Aylward, Philip E.; Bryce, Alfonso; Chen, Hong; Chen, Ming‐Fong; Corbalan, Ramon; Dalby, Anthony J.; Danchin, Nicolas; De Winter, Robbert J.; Denchev, Stefan; Diaz, Rafael; Elisaf, Moses; Flather, Marcus D.; Goudev, Assen R.; Grinfeld, Liliana; Husted, Steen; Kim, Hyo‐Soo; Linhart, Ales; Lonn, Eva; López‐Sendón, José; Manolis, Athanasios J.; Nicolau, José C.; Pais, Prem; Parkhomenko, Alexander; Pedersen, Terje R.; Pella, Daniel; Ramos‐Corrales, Marco A.; Ruda, Mikhail; Sereg, Mátyás; Siddique, Saulat; Sinnaeve, Peter; Sritara, Piyamitr; Swart, Henk P.; Sy, Rody G.; Teramoto, Tamio; Tse, Hung‐Fat; Weaver, W. Douglas; Viigimaa, Margus; Vinereanu, Dragos; Zhu, Junren (John Wiley and Sons Inc., 2016)
      Background: We evaluated lipoprotein‐associated phospholipase A2 (Lp‐PLA 2) activity in patients with stable coronary heart disease before and during treatment with darapladib, a selective Lp‐PLA 2 inhibitor, in relation ...

    • Lipoxin a 4 Stable Analogs Are Potent Mimetics That Stimulate Human Monocytes and THP-1 Cells via a G-protein-linked Lipoxin a 4 Receptor 

      Maddox, Jane F.; Hachicha, Mohamed; Takano, Tomoko; Petasis, Nicos A.; Fokin, Valery V.; Serhan, Charles N. (American Society for Biochemistry and Molecular Biology, 1997)

    • Lipoxin A4 activates ALX/FPR2 Receptor to Regulate Conjunctival Goblet Cell Secretion 

      Hodges, Robin R.; Li, Dayu; Shatos, Marie A.; Bair, Jeffrey A.; Lippestad, Marit; Serhan, Charles N.; Dartt, Darlene A. (2016)
      Conjunctival goblet cells play a major role in maintaining the mucous layer of the tear film under physiological conditions as well as in inflammatory diseases like dry eye and allergic conjunctivitis.. Resolution of ...

    • Lipoxin A4 Counter-regulates Histamine-stimulated Glycoconjugate Secretion in Conjunctival Goblet Cells 

      Hodges, Robin R.; Li, Dayu; Shatos, Marie A.; Serhan, Charles N.; Dartt, Darlene A. (Nature Publishing Group, 2016)
      Conjunctival goblet cells synthesize and secrete mucins which play an important role in protecting the ocular surface. Pro-resolution mediators, such as lipoxin A4 (LXA4), are produced during inflammation returning the ...

    • Lipoxin A4 Regulates Natural Killer Cell and Type 2 Innate Lymphoid Cell Activation in Asthma 

      Barnig, Cindy; Cernadas, Manuela; Dutile, Stefanie; Liu, Xiaoli; Perrella, Mark; Kazani, Shamsah; Wechsler, Michael E.; Israel, Elliot; Levy, Bruce (American Association for the Advancement of Science (AAAS), 2013-02-27)
      Asthma is a prevalent disease of chronic inflammation in which endogenous counter-regulatory signaling pathways are dysregulated. Recent evidence suggests that innate lymphoid cells (ILCs), including natural killer (NK) ...

    • Lipoxins and aspirin-triggered lipoxin inhibit inflammatory pain processing 

      Svensson, Camilla; Zattoni, Michela; Serhan, Charles (Rockefeller University Press, 2007)
      Inflammatory conditions can lead to debilitating and persistent pain. This hyperalgesia reflects sensitization of peripheral terminals and facilitation of pain signaling at the spinal level. Studies of peripheral systems ...

    • Liquid Versus Tissue Biopsy for Detecting Acquired Resistance and Tumor Heterogeneity in Gastrointestinal Cancers 

      Leshchiner, Ignaty; Elagina, Liudmila; Goyal, Lipika; Siravegna, Giulia; Livitz, Dimitri; Hanna, Megan; Wong, Alicia; Fece de la Cruz, Ferran; Giantonio, Bruce; Roeland, Eric; Ryan, David P.; Aguet, François; Hazar-Rethinam, Mehlika; Dias-Santagata, Dora; Bardelli, Alberto; Parida, Laxmi; Juric, Dejan; Getz, Gad; Corcoran, Ryan B.; Parikh, Aparna; Levovitz, Chaya; Rhrissorrakrai, Kahn; Martin, Elizabeth; Van Seventer, Emily; Slowik, Kara; Ultro, Filippo; Pinto, Christopher; Danysh, Brian; Fetter, Isobel; Shahzade, Heather; Nadres, Brandon; Allen, Jill; Blaszkowsky, Lawrence; Clark, Jeffrey; Murphy, Janet; Nipp, Ryan; Weekes, Colin; Kwan, Eunice; Faris, Jason; Wo, Jennifer; Dey-Guha, Ipsita; Ting, David; Zhu, Andrew; Hong, Theodore; Golub, Todd; Iafrate, John; Adalsteinsson, Viktor (Springer Science and Business Media LLC, 2019-09)
      During cancer therapy, tumor heterogeneity can drive the evolution of multiple tumor subclones harboring unique resistance mechanisms in an individual patient1-3. Prior case reports and small case series have suggested ...

    • Lis1 is an initiation factor for dynein-driven organelle transport 

      Egan, Martin; Tan, Kaeling; Reck-Peterson, Samara Louise (The Rockefeller University Press, 2012)
      The molecular motor cytoplasmic dynein is responsible for most minus-end–directed, microtubule-based transport in eukaryotic cells. It is especially important in neurons, where defects in microtubule-based motility have ...

    • Lisdexamfetamine Dimesylate for Adults with Moderate to Severe Binge Eating Disorder: Results of Two Pivotal Phase 3 Randomized Controlled Trials 

      McElroy, Susan L; Hudson, James; Ferreira-Cornwell, M Celeste; Radewonuk, Jana; Whitaker, Timothy; Gasior, Maria (Nature Publishing Group, 2016)
      The efficacy and safety of lisdexamfetamine dimesylate (LDX) vs placebo in binge eating disorder (BED) was evaluated in two multicenter, double-blind, placebo-controlled trials. Adults (study 1, n=383; study 2, n=390) ...

    • Listeria monocytogenes exploits efferocytosis to promote cell-to-cell spread 

      Czuczman, Mark A.; Fattouh, Ramzi; van Rijn, Jorik; Canadien, Veronica; Osborne, Suzanne; Muise, Aleixo M.; Kuchroo, Vijay K.; Higgins, Darren E.; Brumell, John H. (2014)
      Efferocytosis, the process by which dying/dead cells are removed by phagocytosis, plays an important role in development, tissue homeostasis and innate immunity1. Efferocytosis is mediated, in part, by receptors that bind ...

    • Listeria monocytogenes Infection in Caspase-11-Deficient Mice 

      Mueller, Nicholas J.; Wilkinson, Robert A.; Fishman, Jay Alan (American Society for Microbiology, 2002)
      Caspase-11 (Cas11) is a cysteine protease involved in programmed cell death and cytokine maturation. Through activation of Cas1 (interleukin-1 [IL-1 ]-converting enzyme), Cas11 is directly involved in the maturation of ...

    • Literature Lab: A Method of Automated Literature Interrogation to Infer Biology from Microarray Analysis 

      Febbo, Phillip G; Mulligan, Mike G; Slonina, David A; Stegmeir, Kimberly; Di Vizio, Dolores; Martinez, Paul R.; Loda, Massimo; Taylor, Stephen (BioMed Central, 2007)
      Background: The biomedical literature is a rich source of associative information but too vast for complete manual review. We have developed an automated method of literature interrogation called "Literature Lab" that ...

    • A literature search tool for intelligent extraction of disease-associated genes 

      Jung, Jae-Yoon; DeLuca, Todd F; Nelson, Tristan H; Wall, Dennis P (BMJ Publishing Group, 2014)
      Objective: To extract disorder-associated genes from the scientific literature in PubMed with greater sensitivity for literature-based support than existing methods. Methods: We developed a PubMed query to retrieve ...