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Local proliferation dominates lesional macrophage accumulation in atherosclerosis
(2013)
During the inflammatory response that drives atherogenesis, macrophages accumulate progressively in the expanding arterial wall1,2. The observation that circulating monocytes give rise to lesional macrophages3–9 has ...
Rapid monocyte kinetics in acute myocardial infarction are sustained by extramedullary monocytopoiesis
(The Rockefeller University Press, 2012)
IL-1b signaling augments continued splenic monocyte supply during acute inflammation.
Myocardial Infarction Accelerates Atherosclerosis
(Nature Publishing Group, 2012)
During progression of atherosclerosis, myeloid cells destabilize lipid-rich plaque in the arterial wall and cause its rupture, thus triggering myocardial infarction and stroke. Survivors of acute coronary syndromes have a ...
Resolving Cancer-Stroma Interfacial Signaling and Interventions with Micropatterned Tumor-Stromal Assays
(2014)
Tumor-stromal interactions are a determining factor in cancer progression. In vivo, the interaction interface is associated with spatially-resolved distributions of cancer and stromal phenotypes. Here, we establish a ...
In vivo cell cycle profiling in xenograft tumors by quantitative intravital microscopy
(2015)
Quantification of cell-cycle state at a single-cell level is essential to understand fundamental three-dimensional biological processes such as tissue development and cancer. Analysis of 3D in vivo images, however, is very ...
Pleural innate response activator B cells protect against pneumonia via a GM-CSF-IgM axis
(The Rockefeller University Press, 2014)
Pneumonia is a major cause of mortality worldwide and a serious problem in critical care medicine, but the immunophysiological processes that confer either protection or morbidity are not completely understood. We show ...
Proliferation and Recruitment Contribute to Myocardial Macrophage Expansion in Chronic Heart Failure
(Ovid Technologies (Wolters Kluwer Health), 2016)
Rationale: Macrophages reside in the healthy myocardium, participate in ischemic heart disease, and modulate myocardial infarction (MI) healing. Their origin and roles in post-MI remodeling of nonischemic remote myocardium, ...
Lp-PLA 2 Antagonizes Left Ventricular Healing After Myocardial Infarction by Impairing the Appearance of Reparative MacrophagesCLINICAL PERSPECTIVE
(Ovid Technologies (Wolters Kluwer Health), 2015)
Background—Healing after myocardial infarction (MI) involves the biphasic accumulation of inflammatory Ly-6Chigh and reparative Ly-6Clow monocytes/macrophages. Excessive inflammation disrupts the balance between the 2 ...
Chronic variable stress activates hematopoietic stem cells
(2014)
Exposure to psychosocial stress is a risk factor for many diseases, including atherosclerosis1,2. While incompletely understood, interaction between the psyche and the immune system provides one potential mechanism linking ...
On-demand erythrocyte disposal and iron recycling requires transient macrophages in the liver
(2016)
Iron is an essential component of the erythrocyte protein hemoglobin and is crucial to oxygen transport in vertebrates. In the steady state, erythrocyte production is in equilibrium with erythrocyte removal1. In various ...