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Tyrosine kinase-mediated axial motility of basal cells revealed by intravital imaging
(Nature Publishing Group, 2016)
Epithelial cells are generally considered to be static relative to their neighbours. Basal cells in pseudostratified epithelia display a single long cytoplasmic process that can cross the tight junction barrier to reach ...
A magneto-DNA nanoparticle system for the rapid and sensitive diagnosis of enteric fever
(Nature Publishing Group, 2016)
There is currently no widely available optimal assay for diagnosing patients with enteric fever. Here we present a novel assay designed to detect amplified Salmonella nucleic acid (mRNA) using magneto-DNA probes and a ...
Macrophages retain hematopoietic stem cells in the spleen via VCAM-1
(The Rockefeller University Press, 2015)
Splenic myelopoiesis provides a steady flow of leukocytes to inflamed tissues, and leukocytosis correlates with cardiovascular mortality. Yet regulation of hematopoietic stem cell (HSC) activity in the spleen is incompletely ...
Imaging Cellular Distribution of Bcl Inhibitors Using Small Molecule Drug Conjugates
(American Chemical
Society, 2014)
Overexpression of anti-apoptotic proteins such as Bcl-2 is a cellular mechanism to evade apoptosis; consequently, Bcl-2 inhibitors are being developed as anticancer agents. In this work, we have synthesized a fluorescent ...
Point-of-Care Technologies for Precision Cardiovascular Care and Clinical Research
(Elsevier BV, 2016)
Point-of-care technologies (POC or POCT) are enabling innovative cardiovascular diagnostics that promise to improve patient care across diverse clinical settings. The National Heart, Lung, and Blood Institute convened a ...
Rapid, high efficiency isolation of pancreatic ß-cells
(Nature Publishing Group, 2015)
The ability to isolate pure pancreatic ß-cells would greatly aid multiple areas of diabetes research. We developed a fluorescent exendin-4-like neopeptide conjugate for the rapid purification and isolation of functional ...
Myocardial Infarction Activates CCR2+ Hematopoietic Stem and Progenitor Cells
(Elsevier BV, 2015)
Following myocardial infarction (MI), myeloid cells derived from the hematopoietic system drive a sharp increase in systemic leukocyte levels that correlates closely with mortality. The origin of these myeloid cells, and ...
Lp-PLA2 Antagonizes Left Ventricular Healing After Myocardial Infarction by Impairing the Appearance of Reparative Macrophages
(Lippincott Williams & Wilkins, 2015)
Background— Healing after myocardial infarction (MI) involves the biphasic accumulation of inflammatory Ly-6Chigh and reparative Ly-6Clow monocytes/macrophages. Excessive inflammation disrupts the balance between the 2 ...
Use of 18F-2-Fluorodeoxyglucose to Label Antibody Fragments for Immuno-Positron Emission Tomography of Pancreatic Cancer
(American Chemical Society, 2015)
We generated 18F-labeled antibody fragments for positron emission tomography (PET) imaging using a sortase-mediated reaction to install a trans-cyclooctene-functionalized short peptide onto proteins of interest, followed ...
Immunogenic chemotherapy sensitizes tumors to checkpoint blockade therapy
(Elsevier, 2016)
Checkpoint blockade immunotherapies can be extraordinarily effective, but might benefit only the minority of patients whose tumors are pre-infiltrated by T cells. Here, using lung adenocarcinoma mouse models, including ...