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Transient and Persistent Pain Induced Connectivity Alterations in Pediatric Complex Regional Pain Syndrome
(Public Library of Science, 2013)
Evaluation of pain-induced changes in functional connectivity was performed in pediatric complex regional pain syndrome (CRPS) patients. High field functional magnetic resonance imaging was done in the symptomatic painful ...
Altered Hypothalamic Functional Connectivity with Autonomic Circuits and the Locus Coeruleus in Migraine
(Public Library of Science, 2014)
The hypothalamus has been implicated in migraine based on the manifestation of autonomic symptoms with the disease, as well as neuroimaging evidence of hypothalamic activation during attacks. Our objective was to determine ...
An Approach to Localizing Corneal Pain Representation in Human Primary Somatosensory Cortex
(Public Library of Science, 2012)
The cornea has been a focus of animal electrophysiological research for decades, but little is known regarding its cortical representation in the human brain. This study attempts to localize the somatotopic representation ...
Pain Facilitation Brain Regions Activated by Nalbuphine Are Revealed by Pharmacological fMRI
(Public Library of Science, 2013)
Nalbuphine, an agonist-antagonist kappa-opioid, produces brief analgesia followed by enhanced pain/hyperalgesia in male postsurgical patients. However, it produces profound analgesia without pain enhancement when ...
Frontal Lobe Hemodynamic Responses to Painful Stimulation: A Potential Brain Marker of Nociception
(Public Library of Science, 2016)
The purpose of this study was to use functional near-infrared spectroscopy (fNIRS) to examine patterns of both activation and deactivation that occur in the frontal lobe in response to noxious stimuli. The frontal lobe was ...
Capturing Pain in the Cortex during General Anesthesia: Near Infrared Spectroscopy Measures in Patients Undergoing Catheter Ablation of Arrhythmias
(Public Library of Science, 2016)
The predictability of pain makes surgery an ideal model for the study of pain and the development of strategies for analgesia and reduction of perioperative pain. As functional near-infrared spectroscopy reproduces the ...
Calcitonin Gene-Related Peptide Modulates Heat Nociception in the Human Brain - An fMRI Study in Healthy Volunteers
(Public Library of Science, 2016)
Background: Intravenous infusion of calcitonin-gene-related-peptide (CGRP) provokes headache and migraine in humans. Mechanisms underlying CGRP-induced headache are not fully clarified and it is unknown to what extent CGRP ...
Abdominal Pain, the Adolescent and Altered Brain Structure and Function
(Public Library of Science, 2016)
Irritable bowel syndrome (IBS) is a functional gastrointestinal (GI) disorder of unknown etiology. Although relatively common in children, how this condition affects brain structure and function in a pediatric population ...