Browsing HMS Scholarly Articles by Title

Now showing items 16283-16302 of 17928

    • The T300A Crohn's disease risk polymorphism impairs function of the WD40 domain of ATG16L1 

      Boada-Romero, Emilio; Serramito-Gómez, Inmaculada; Sacristán, María P.; Boone, David L.; Xavier, Ramnik J.; Pimentel-Muiños, Felipe X. (Nature Publishing Group, 2016)
      A coding polymorphism of human ATG16L1 (rs2241880; T300A) increases the risk of Crohn's disease and it has been shown to enhance susceptibility of ATG16L1 to caspase cleavage. Here we show that T300A also alters the ability ...

    • Tablet Keyboard Configuration Affects Performance, Discomfort and Task Difficulty for Thumb Typing in a Two-Handed Grip 

      Trudeau, Matthieu B.; Catalano, Paul J.; Jindrich, Devin L.; Dennerlein, Jack T. (Public Library of Science, 2013)
      When holding a tablet computer with two hands, the touch keyboard configuration imposes postural constraints on the user because of the need to simultaneously hold the device and type with the thumbs. Designers have provided ...

    • Tai Chi and Vestibular Rehabilitation Improve Vestibulopathic Gait via Different Neuromuscular Mechanisms: Preliminary Report 

      McGibbon, Chris A; Krebs, David E; Parker, Stephen William; Scarborough, Donna M; Wayne, Peter Michael; Wolf, Steven L (BioMed Central, 2005)
      Background: Vestibular rehabilitation (VR) is a well-accepted exercise program intended to remedy balance impairment caused by damage to the peripheral vestibular system. Alternative therapies, such as Tai Chi (TC), have ...

    • Tai Chi for Osteopenic Women: Design and Rationale of a Pragmatic Randomized Controlled Trial 

      Wayne, Peter Michael; Buring, Julie Elizabeth; Davis, Roger B.; Connors, Ellen M; Bonato, Paolo; Patritti, Benjamin Lorenzo; Fischer, Mary; Yeh, Gloria Y.; Cohen, Calvin Jay; Carroll, Danette; Kiel, Douglas P. (BioMed Central, 2010)
      Background: Post-menopausal osteopenic women are at increased risk for skeletal fractures. Current osteopenia treatment guidelines include exercise, however, optimal exercise regimens for attenuating bone mineral density ...

    • Tai chi mind-body exercise in patients with COPD: study protocol for a randomized controlled trial 

      Yeh, Gloria Y; Wayne, Peter M; Litrownik, Daniel; Roberts, David H; Davis, Roger B; Moy, Marilyn L (BioMed Central, 2014)
      Background: Chronic obstructive pulmonary disease (COPD) is a chronic, progressively debilitating condition that is prevalent in the US and worldwide. Patients suffer from progressive dyspnea and exercise intolerance. ...

    • Tai Chi Training may Reduce Dual Task Gait Variability, a Potential Mediator of Fall Risk, in Healthy Older Adults: Cross-Sectional and Randomized Trial Studies 

      Wayne, Peter M.; Hausdorff, Jeffrey M.; Lough, Matthew; Gow, Brian J.; Lipsitz, Lewis; Novak, Vera; Macklin, Eric A.; Peng, Chung-Kang; Manor, Brad (Frontiers Media S.A., 2015)
      Background: Tai Chi (TC) exercise improves balance and reduces falls in older, health-impaired adults. TC’s impact on dual task (DT) gait parameters predictive of falls, especially in healthy active older adults, however, ...

    • Tailored transgene expression to specific cell types in the central nervous system after peripheral injection with AAV9 

      Dashkoff, Jonathan; Lerner, Eli P; Truong, Nhi; Klickstein, Jacob A; Fan, Zhanyun; Mu, Dakai; Maguire, Casey A; Hyman, Bradley T; Hudry, Eloise (Nature Publishing Group, 2016)
      The capacity of certain adeno-associated virus (AAV) vectors to cross the blood–brain barrier after intravenous delivery offers a unique opportunity for noninvasive brain delivery. However, without a well-tailored system, ...

    • Tailoring Adjuvant Radiation Therapy by Intraoperative Imaging to Detect Residual Cancer 

      Whitley, Melodi; Weissleder, Ralph; Kirsch, David (Elsevier, 2015)
      For many solid cancers, radiation therapy is offered as an adjuvant to surgical resection to lower rates of local recurrence and improve survival. However, a subset of patients treated with surgery alone will not have a ...

    • Tailoring the genome: the power of genetic approaches 

      Nagy, Andras; Perrimon, Norbert; Sandmeyer, Suzanne; Plasterk, Ronald (Nature Research (part of Springer Nature), 2003)
      In the last century, genetics has developed into one of the most powerful tools for addressing basic questions concerning inheritance, development, individual and social operations and death. Here we summarize the current ...

    • TAK1 is an Essential Regulator of BMP Signalling in Cartilage 

      Shim, Jae-Hyuck; Greenblatt, Matthew Blake; Xie, Min; Schneider, Michael D; Zou, Weigou; Zhai, Bo; Gygi, Steven P.; Glimcher, Laurie Hollis (Nature Publishing Group, 2009)
      TGFβ activated kinase 1 (TAK1), a member of the MAPKKK family, controls diverse functions ranging from innate and adaptive immune system activation to vascular development and apoptosis. To analyse the in vivo function of ...

    • “Take it up a NOTCH": Novel Strategies for Cancer Therapy 

      Morgan, Stefanie L.; Wyant, Gregory A.; Dinulescu, Daniela M (Landes Bioscience, 2013)

    • Take the money and run? Redemption of a gift card incentive in a clinician survey 

      Chen, Jane S.; Sprague, Brian L.; Klabunde, Carrie N.; Tosteson, Anna N. A.; Bitton, Asaf; Onega, Tracy; MacLean, Charles D.; Harris, Kimberly; Schapira, Marilyn M.; Haas, Jennifer S. (BioMed Central, 2016)
      Background: Clinician surveys provide critical information about many facets of health care, but are often challenging to implement. Our objective was to assess use by participants and non-participants of a prepaid gift ...

    • Taking Control of Castleman Disease: Leveraging Precision Medicine Technologies to Accelerate Rare Disease Research 

      Newman, Samantha Kass; Jayanthan, Raj K.; Mitchell, Grant W.; Carreras Tartak, Jossie A.; Croglio, Michael P.; Suarez, Alexander; Liu, Amy Y.; Razzo, Beatrice M.; Oyeniran, Enny; Ruth, Jason R.; Fajgenbaum, David C. (YJBM, 2015)
      Castleman disease (CD) is a rare and heterogeneous disorder characterized by lymphadenopathy that may occur in a single lymph node (unicentric) or multiple lymph nodes (multicentric), the latter typically occurring secondary ...

    • Taking the brakes off telomerase 

      Naxerova, Kamila; Elledge, Stephen J (eLife Sciences Publications, Ltd, 2015)
      Studies using human embryonic stem cells have revealed how common cancer-associated mutations exert their effect on telomerase after cells differentiate into more specialized cell types.

    • Taking the lag out of jet lag through model-based schedule design 

      Dean, Dennis A.; Forger, Daniel B.; Klerman, Elizabeth Beryl (Public Library of Science, 2009)
      Travel across multiple time zones results in desynchronization of environmental time cues and the sleep–wake schedule from their normal phase relationships with the endogenous circadian system. Circadian misalignment can ...

    • Takotsubo Cardiomyopathy: A New Perspective in Asthma 

      Marmoush, Fady Y.; Barbour, Mohamad F.; Noonan, Thomas E.; Al-Qadi, Mazen O. (Hindawi Publishing Corporation, 2015)
      Takotsubo cardiomyopathy (TCM) is an entity of reversible cardiomyopathy known for its association with physical or emotional stress and may mimic myocardial infarction. We report an exceedingly rare case of albuterol-induced ...

    • The TAL1 complex targets the FBXW7 tumor suppressor by activating miR-223 in human T cell acute lymphoblastic leukemia 

      Mansour, Marc R.; Sanda, Takaomi; Lawton, Lee N.; Li, Xiaoyu; Kreslavsky, Taras; Novina, Carl D.; Brand, Marjorie; Gutierrez, Alejandro; Kelliher, Michelle A.; Jamieson, Catriona H.M.; von Boehmer, Harald; Young, Richard A.; Look, A. Thomas (The Rockefeller University Press, 2013)
      The oncogenic transcription factor TAL1/SCL is aberrantly expressed in 60% of cases of human T cell acute lymphoblastic leukemia (T-ALL) and initiates T-ALL in mouse models. By performing global microRNA (miRNA) expression ...

    • Talc Use, Variants of the GSTM1, GSTT1, and NAT2 Genes, and Risk of Epithelial Ovarian Cancer 

      Gates, M. A.; Tworoger, Shelley Slate; Terry, Kathryn Lynne; Titus-Ernstoff, L.; Rosner, Bernard Alfred; De Vivo, Immaculata; Cramer, Daniel William; Hankinson, Susan Elizabeth (American Association for Cancer Research (AACR), 2008)
      Epidemiologic evidence suggests a possible association between genital use of talcum powder and risk of epithelial ovarian cancer; however, the biological basis for this association is not clear. We analyzed interactions ...

    • A Tale of Two Methods: Chart and Interview Methods for Identifying Delirium 

      Saczynski, Jane S.; Kosar, Cyrus M.; Xu, Guoquan; Puelle, Margaret R.; Schmitt, Eva; Jones, Richard Norman; Marcantonio, Edward Ralph; Wong, Bonnie; Isaza, Ilean; Inouye, Sharon (Wiley-Blackwell, 2014)
      OBJECTIVES: To compare chart- and interview-based methods for identification of delirium. DESIGN: Prospective cohort study. SETTING: Two academic medical centers. PARTICIPANTS: Individuals aged 70 and older undergoing ...

    • Tamoxifen may prevent both ER+ and ER- breast cancers and select for ER- carcinogenesis: an alternative hypothesis 

      Esserman, Laura J; Ozanne, Elissa M.; Dowsett, Mitch; Slingerland, Joyce M (BioMed Central, 2005)
      Introduction: Breast Cancer Prevention Trial (BCPT) and Multiple Outcomes of Raloxifene (MORE) data have been interpreted to indicate that tamoxifen reduces the risk of ER+ but not ER- breast carcinogenesis. We explored ...