Browsing HMS Scholarly Articles by Title

Now showing items 2087-2106 of 17928

    • Cardiac and inflammatory biomarkers do not correlate with volume of heart or lung receiving radiation 

      Kuo, Angera H; Ancukiewicz, Marek; Kozak, Kevin R; Yock, Torunn I; Padera, Timothy P (BioMed Central, 2015)
      Background: Thoracic and cardiac irradiation increases the risk of pulmonary and cardiovascular disease. In addition, radiation, often in combination with chemotherapy, can cause treatment-related pneumonitis. Previously, ...

    • Cardiac Angiogenic Imbalance Leads to Peripartum Cardiomyopathy 

      Patten, Ian S.; Farrell, Caitlin; Tudorache, Igor; Bauersachs, Johann; Hilfiker-Kleiner, Denise; Rana, Sarosh; Shahul, Sajid Saleem; Rowe, Glenn C; Jang, Cholsoon; Liu, Laura; Hacker, Michele Renee; Rhee, Julie S; Mitchell, John D.; Mahmood, Feroze-Ud-Den; Hess, Philip E.; Koulisis, Nicole; Khankin, Eliyahu; Burke, Suzanne Diana; Del Monte, Federica; Karumanchi, Subbian Ananth; Arany, Zoltan Pierre (Nature Publishing Group, 2012)
      Peripartum cardiomyopathy (PPCM) is an often fatal disease that affects pregnant women who are near delivery, and it occurs more frequently in women with pre-eclampsia and/or multiple gestation. The aetiology of PPCM, and ...

    • Cardiac Autoimmunity as a Novel Biomarker, Mediator, and Therapeutic Target of Heart Disease in Type 1 Diabetes 

      Lipes, Myra A.; Galderisi, Alfonso (Springer US, 2015)
      Patients with type 1 diabetes (T1D) suffer excess mortality from cardiovascular disease (CVD) that has persisted despite substantial reductions in microvascular complications. Although T1D and type 2 diabetes (T2D) are ...

    • Cardiac Autonomic Dysfunction: Particulate Air Pollution Effects Are Modulated by Epigenetic Immunoregulation of Toll‐like Receptor 2 and Dietary Flavonoid Intake 

      Zhong, Jia; Colicino, Elena; Lin, Xinyi; Mehta, Amar; Kloog, Itai; Zanobetti, Antonella; Byun, Hyang‐Min; Bind, Marie‐Abèle; Cantone, Laura; Prada, Diddier; Tarantini, Letizia; Trevisi, Letizia; Sparrow, David; Vokonas, Pantel; Schwartz, Joel; Baccarelli, Andrea A. (Blackwell Publishing Ltd, 2015)
      Background: Short‐term fine particles (PM2.5) exposure is associated with reduced heart rate variability, a strong predictor of cardiac mortality among older people. Identifying modifiable factors that confer susceptibility ...

    • Cardiac Hypertrophy Involves both Myocyte Hypertrophy and Hyperplasia in Anemic Zebrafish 

      Sun, Xiaojing; Hoage, Tiffany; Ding, Yonghe; Chen, Zhenyue; Zhang, Ruilin; Jahangir, Ashad; Xu, Xiaolei; Paw, Barry Htin; Bai, Ping; Huang, Wei; Li, Yi-Gang (Public Library of Science, 2009)
      Background: An adult zebrafish heart possesses a high capacity of regeneration. However, it has been unclear whether and how myocyte hyperplasia contributes to cardiac remodeling in response to biomechanical stress and ...

    • Cardiac Magnetic Resonance Assessment of Interstitial Myocardial Fibrosis and Cardiomyocyte Hypertrophy in Hypertensive Mice Treated With Spironolactone 

      Coelho‐Filho, Otavio R.; Shah, Ravi V.; Neilan, Tomas G.; Mitchell, Richard; Moreno, Heitor; Kwong, Raymond; Jerosch‐Herold, Michael (Blackwell Publishing Ltd, 2014)
      Background: Nearly 50% of patients with heart failure (HF) have preserved LV ejection fraction, with interstitial fibrosis and cardiomyocyte hypertrophy as early manifestations of pressure overload. However, methods to ...

    • Cardiac mitochondria exhibit dynamic functional clustering 

      Kurz, Felix T.; Aon, Miguel A.; O'Rourke, Brian; Armoundas, Antonis A. (Frontiers Media S.A., 2014)
      Multi-oscillatory behavior of mitochondrial inner membrane potential ΔΨm in self-organized cardiac mitochondrial networks can be triggered by metabolic or oxidative stress. Spatio-temporal analyses of cardiac mitochondrial ...

    • Cardiac MRI with Concurrent Physiological Monitoring Using MRI-Compatible 12-Lead ECG 

      Tse, Zion; Dumoulin, Charles; Clifford, Gari D; Oster, Julien; Jerosch-Herold, Michael; Kwong, Raymond Yan-Kit; Stevenson, William Gregory; Schmidt, Ehud Jeruham (BioMed Central, 2012)

    • Cardiac Output Monitoring Managing Intravenous Therapy (COMMIT) to Treat Emergency Department Patients with Sepsis 

      Hou, Peter C.; Filbin, Michael R.; Napoli, Anthony; Feldman, Joseph; Pang, Peter S.; Sankoff, Jeffrey; Lo, Bruce M.; Dickey-White, Howard; Birkhahn, Robert H.; Shapiro, Nathan I. (Lippincott Williams & Wilkins, 2016)
      ABSTRACT Objective: Fluid responsiveness is proposed as a physiology-based method to titrate fluid therapy based on preload dependence. The objectives of this study were to determine if a fluid responsiveness protocol would ...

    • Cardiac sarcoidosis with severe involvement of the right ventricle: a case report 

      Siqueira, Weverton César; da Cruz, Samuel Gonçalves; Asimaki, Angeliki; Saffitz, Jeffrey Ern; Moreira, Maria da Consolação Vieira; Brasileiro, Geraldo; Rocha, Luiz Otávio Savassi (São Paulo, SP: Universidade de São Paulo, Hospital Universitário, 2015)
      We present the case of a patient who underwent cardiac transplantation with the diagnosis of idiopathic dilated cardiomyopathy. Once the explanted heart was examined, a type of granulomatous myocarditis compatible with ...

    • Cardiac Sarcoidosis: Case Report, Workup, and Review of the Literature 

      Plitt, Anna; Dorbala, Sharmila; Albert, Michelle A.; Giugliano, Robert P. (Springer Healthcare, 2013)
      Introduction: Cardiovascular disease is the leading cause of death worldwide, with coronary heart disease being the most common manifestation disease. While deaths attributed to coronary heart disease are falling in the ...

    • Cardioplegia and Diazoxide Modulate STAT3 Activation and DNA Binding 

      Hsieh, Yng-Ju; Wakiyama, Hidetaka; Levitsky, Sidney; McCully, James Donald (Elsevier BV, 2007)
      Background Previously, we have shown that magnesium supplemented potassium (DSA) cardioplegia and DSA containing diazoxide (DSA+DZX) significantly decrease apoptosis after ischemia. The mechanism for this enhanced ...

    • Cardioplegia at subnormothermia facilitates rapid functional resuscitation of hearts preserved in SOMAH for transplants 

      Lowalekar, Samar K; Treanor, Patrick R; Thatte, Hemant S (BioMed Central, 2014)
      Objectives: Hearts preserved ex vivo at 4°C undergo time-dependent irreversible injury due to extreme hypothermia. Studies using novel organ preservative solution SOMAH, suggest that hearts are optimally ‘preserved’ at ...

    • Cardiopulmonary Exercise Test: Background, Applicability and Interpretation 

      Herdy, Artur Haddad; Ritt, Luiz Eduardo Fonteles; Stein, Ricardo; de Araújo, Claudio Gil Soares; Milani, Mauricio; Meneghelo, Romeu Sérgio; Ferraz, Almir Sérgio; Hossri, Carlos; de Almeida, Antonio Eduardo Monteiro; Fernandes-Silva, Miguel Morita; Serra, Salvador Manoel (Sociedade Brasileira de Cardiologia - SBC, 2016)
      Cardiopulmonary exercise test (CPET) has been gaining importance as a method of functional assessment in Brazil and worldwide. In its most frequent applications, CPET consists in applying a gradually increasing intensity ...

    • Cardiopulmonary Exercise Testing in Lung Transplantation: A Review 

      Dudley, Katherine Ann; El-Chemaly, Souheil (Hindawi Publishing Corporation, 2012)
      There has been an increase in lung transplantation in the USA. Lung allocation is guided by the lung allocation score (LAS), which takes into account one measure of exercise capacity, the 6-minute walk test (6MWT). There ...

    • Cardiorespiratory fitness is associated with white matter integrity in aging 

      Hayes, Scott M; Salat, David H; Forman, Daniel E; Sperling, Reisa A; Verfaellie, Mieke (John Wiley & Sons, Ltd, 2015)
      Objective: Aging is associated with reduced neural integrity, yet there are remarkable individual differences in brain health among older adults (OA). One factor that may attenuate age-related neural decline is cardiorespiratory ...

    • Cardiorespiratory fitness, body mass index, and cancer mortality: a cohort study of Japanese men 

      Sawada, Susumu S; Lee, I-Min; Naito, Hisashi; Kakigi, Ryo; Goto, Sataro; Kanazawa, Masaaki; Okamoto, Takashi; Tsukamoto, Koji; Muto, Takashi; Tanaka, Hiroaki; Blair, Steven N (BioMed Central, 2014)
      Background: The aim of this study is to investigate the independent and joint effects of cardiorespiratory fitness (CRF) and body mass index (BMI) on cancer mortality in a low body mass index population. Methods: We evaluated ...

    • Cardioscopic Tool-Delivery Instrument for Beating-Heart Surgery 

      Ataollahi, Asghar; Berra, Ignacio; Vasilyev, Nikolay; Machaidze, Zurab; Dupont, Pierre E (Institute of Electrical and Electronics Engineers (IEEE), 2016)
      This paper describes an instrument that provides solutions to two open challenges in beating-heart intracardiac surgery - providing high-fidelity imaging of tool-tissue contact and controlling tool penetration into tissue ...

    • Cardiovascular and neuropsychiatric safety of varenicline and bupropion compared with nicotine replacement therapy for smoking cessation: study protocol of a retrospective cohort study using the QResearch general practice database 

      Kotz, Daniel; Simpson, Colin; Viechtbauer, Wolfgang; van Schayck, Onno C P; West, Robert; Sheikh, Aziz (BMJ Publishing Group, 2014)
      Introduction: Cigarette smoking continues to be the leading cause of preventable death and is the main risk factor of major diseases such as chronic obstructive pulmonary disease (COPD). The best treatment to help smokers ...

    • Cardiovascular and pharmacological implications of haem-deficient NO-unresponsive soluble guanylate cyclase knock-in mice 

      Thoonen, Robrecht; Cauwels, Anje; Decaluwe, Kelly; Geschka, Sandra; Tainsh, Robert; Delanghe, Joris; Hochepied, Tino; De Cauwer, Lode; Rogge, Elke; Voet, Sofie; Sips, Patrick; Karas, Richard H.; Bloch, Kenneth; Vuylsteke, Marnik; Stasch, Johannes-Peter; Van de Voorde, Johan; Buys, Emmanuel; Brouckaert, Peter (Springer Nature, 2015)
      Oxidative stress, a central mediator of cardiovascular disease, results in loss of the prosthetic haem group of soluble guanylate cyclase (sGC), preventing its activation by nitric oxide (NO). Here we introduce Apo-sGC ...