Browsing HMS Scholarly Articles by Title
Now showing items 254-273 of 17928
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Acetylation-dependent regulation of essential iPS-inducing factors: a regulatory crossroad for pluripotency and tumorigenesis
(Blackwell Publishing Ltd, 2014)Induced pluripotent stem (iPS) cells can be generated from somatic cells by coexpression of four transcription factors: Sox2, Oct4, Klf4, and c-Myc. However, the low efficiency in generating iPS cells and the tendency of ... -
Achieving consensus for clinical trials: The REiNS International Collaboration
(Ovid Technologies (Wolters Kluwer Health), 2013)The neurofibromatoses (NF)—including neurofibromatosis 1 (NF1), neurofibromatosis 2 (NF2), and schwannomatosis—are related tumor-suppressor syndromes characterized by a predisposition to multiple tumor types and other ... -
Achieving Goals in Geriatric Assessment: Role of Caregiver Agreement and Adherence to Recommendations
(Wiley-Blackwell, 2004)Objectives: To determine predictors of recommendation adherence and goal attainment of family caregivers of patients at a geriatric assessment center. Design: One‐year prospective cohort study. Setting: Outpatient geriatric ... -
Acid Suppression Therapy Does Not Predispose to Clostridium difficile Infection: The Case of the Potential Bias
(Public Library of Science, 2014)Objective: An adverse effect of acid-suppression medications on the occurrence of Clostridium difficile infection (CDI) has been a common finding of many, but not all studies. We hypothesized that association between ... -
The Acid Test of Fluoride: How pH Modulates Toxicity
(Public Library of Science, 2010)Background: It is not known why the ameloblasts responsible for dental enamel formation are uniquely sensitive to fluoride (\(F^−\)). Herein, we present a novel theory with supporting data to show that the low pH environment ... -
Acidic Extracellular pH Induces Vascular Endothelial Growth Factor (VEGF) in Human Glioblastoma Cells via ERK1/2 MAPK Signaling Pathway
(American Society for Biochemistry and Molecular Biology, 2002) -
Acidic fibroblast growth factor enhances regeneration of processes by postnatal mammalian retinal ganglion cells in culture.
(Proceedings of the National Academy of Sciences, 1988)Postnatal rat retinal ganglion cells (RGCs) were identified with specific fluorescent labels and placed in culture. Under these conditions, the outgrowth of processes by RGCs was found to be promoted to a far greater degree ... -
Acid–base balance, serum electrolytes and need for non-invasive ventilation in patients with hypercapnic acute exacerbation of chronic obstructive pulmonary disease admitted to an internal medicine ward
(BioMed Central, 2016)Background: Hypoventilation produces or worsens respiratory acidosis in patients with hypercapnia due to acute exacerbations of chronic obstructive pulmonary disease (AECOPD). In these patients acid–base and hydroelectrolite ... -
Acinar Cystadenoma of the Pancreas
(Ovid Technologies (Wolters Kluwer Health), 2012)Pancreatic acinar cystadenomas (ACAs) are rare cystic lesions showing acinar differentiation with benign outcome. Although debated, ACAs are favored to be neoplastic and potentially the benign counterpart of acinar ... -
ACME: Automated Cell Morphology Extractor for Comprehensive Reconstruction of Cell Membranes
(Public Library of Science, 2012)The quantification of cell shape, cell migration, and cell rearrangements is important for addressing classical questions in developmental biology such as patterning and tissue morphogenesis. Time-lapse microscopic imaging ... -
Acne Treatment Based on Selective Photothermolysis of Sebaceous Follicles with Topically Delivered Light-Absorbing Gold Microparticles
(Nature Publishing Group, 2015)The pathophysiology of acne vulgaris depends on active sebaceous glands, implying that selective destruction of sebaceous glands could be an effective treatment. We hypothesized that light-absorbing microparticles could ... -
An acoustic gap between the NICU and womb: a potential risk for compromised neuroplasticity of the auditory system in preterm infants
(Frontiers Media S.A., 2014)The intrauterine environment allows the fetus to begin hearing low-frequency sounds in a protected fashion, ensuring initial optimal development of the peripheral and central auditory system. However, the auditory nursery ... -
Acoustic Purification of Extracellular Microvesicles
(American Chemical Society, 2015)Microvesicles (MVs) are an increasingly important source for biomarker discovery and clinical diagnostics. The small size of MVs and their presence in complex biological environment, however, pose technical challenges in ... -
Acquired acrodermatitis enteropathica after gastric bypass surgery responsive to IV supplementation
(University of California, Davis, 2016)Nutritional deficiency is rare in developed countries, but can be acquired from decreased nutrient intake, reduced absorption, and increased gastrointestinal excretion. We report a patient with acquired acrodermatitis ... -
Acquired and Transmitted Multidrug Resistant Tuberculosis: The Role of Social Determinants
(Public Library of Science, 2016)Although risk factors for multi-drug resistant tuberculosis are known, few studies have differentiated between acquired and transmitted resistance. It is important to identify factors associated with these different ... -
Acquired MET Expression Confers Resistance to EGFR Inhibition In a Mouse Model of Glioblastoma Multiforme
(2013)Glioblastoma Multiforme (GBM) is an aggressive brain tumor for which there is no cure. Overexpression of wild-type EGFR and loss of the tumor suppressor genes Ink4a/Arf and PTEN are salient features of this deadly cancer. ... -
Across-cohort QC analyses of GWAS summary statistics from complex traits
(Nature Publishing Group, 2017)Genome-wide association studies (GWASs) have been successful in discovering SNP trait associations for many quantitative traits and common diseases. Typically, the effect sizes of SNP alleles are very small and this requires ... -
Actin Binding Domains Direct Actin-Binding Proteins to Different Cytoskeletal Locations
(BioMed Central, 2008)Background: Filamin (FLN) and non-muscle α-actinin are members of a family of F-actin cross-linking proteins that utilize Calponin Homology domains (CH-domain) for actin binding. Although these two proteins have been ... -
Actin Disassembly by Cofilin, Coronin, and Aip1 Occurs in Bursts and Is Inhibited by Barbed-end Cappers
(The Rockefeller University Press, 2008)Turnover of actin filaments in cells requires rapid actin disassembly in a cytoplasmic environment that thermodynamically favors assembly because of high concentrations of polymerizable monomers. We here image the disassembly ... -
Actin foci facilitate activation of the phospholipase C-γ in primary T lymphocytes via the WASP pathway
(eLife Sciences Publications, Ltd, 2015)Wiscott Aldrich Syndrome protein (WASP) deficiency results in defects in calcium ion signaling, cytoskeletal regulation, gene transcription and overall T cell activation. The activation of WASP constitutes a key pathway ...