Browsing HMS Scholarly Articles by Title

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    • Essential versus accessory aspects of cell death: recommendations of the NCCD 2015 

      Galluzzi, L; Bravo-San Pedro, J M; Vitale, I; Aaronson, S A; Abrams, J M; Adam, D; Alnemri, E S; Altucci, L; Andrews, D; Annicchiarico-Petruzzelli, M; Baehrecke, E H; Bazan, N G; Bertrand, M J; Bianchi, K; Blagosklonny, M V; Blomgren, K; Borner, C; Bredesen, D E; Brenner, C; Campanella, M; Candi, E; Cecconi, F; Chan, F K; Chandel, N S; Cheng, E H; Chipuk, J E; Cidlowski, J A; Ciechanover, A; Dawson, T M; Dawson, V L; De Laurenzi, V; De Maria, R; Debatin, K-M; Di Daniele, N; Dixit, V M; Dynlacht, B D; El-Deiry, W S; Fimia, G M; Flavell, R A; Fulda, S; Garrido, C; Gougeon, M-L; Green, D R; Gronemeyer, H; Hajnoczky, G; Hardwick, J M; Hengartner, M O; Ichijo, H; Joseph, B; Jost, P J; Kaufmann, T; Kepp, O; Klionsky, D J; Knight, R A; Kumar, S; Lemasters, J J; Levine, B; Linkermann, A; Lipton, S A; Lockshin, R A; López-Otín, C; Lugli, E; Madeo, F; Malorni, W; Marine, J-C; Martin, S J; Martinou, J-C; Medema, J P; Meier, P; Melino, S; Mizushima, N; Moll, U; Muñoz-Pinedo, C; Nuñez, G; Oberst, A; Panaretakis, T; Penninger, J M; Peter, M E; Piacentini, M; Pinton, P; Prehn, J H; Puthalakath, H; Rabinovich, G A; Ravichandran, K S; Rizzuto, R; Rodrigues, C M; Rubinsztein, D C; Rudel, T; Shi, Y; Simon, H-U; Stockwell, B R; Szabadkai, G; Tait, S W; Tang, H L; Tavernarakis, N; Tsujimoto, Y; Vanden Berghe, T; Vandenabeele, P; Villunger, A; Wagner, E F; Walczak, H; White, E; Wood, W G; Yuan, J; Zakeri, Z; Zhivotovsky, B; Melino, G; Kroemer, G (Nature Publishing Group, 2014)
      Cells exposed to extreme physicochemical or mechanical stimuli die in an uncontrollable manner, as a result of their immediate structural breakdown. Such an unavoidable variant of cellular demise is generally referred to ...

    • Established and Novel Initiatives to Reduce Crowding in Emergency Departments 

      Liu, Shan Woo; Hamedani, Azita G.; Brown, David Frank Metzger; Asplin, Brent; Camargo, Carlos Arturo (Department of Emergency Medicine, University of California, Irvine School of Medicine, 2013)
      Introduction: The American College of Emergency Physicians (ACEP) Task Force on Boarding described high-impact initiatives to decrease crowding. Furthermore, some emergency departments (EDs) have implemented a novel ...

    • Established cell surface markers efficiently isolate highly overlapping populations of skeletal muscle satellite cells by fluorescence-activated cell sorting 

      Maesner, Claire C.; Almada, Albert E.; Wagers, Amy J. (BioMed Central, 2016)
      Background: Fluorescent-activated cell sorting (FACS) has enabled the direct isolation of highly enriched skeletal muscle stem cell, or satellite cell, populations from postnatal tissue. Several distinct surface marker ...

    • Establishing and Sustaining a Prospective Screening Program for Breast Cancer-Related Lymphedema at the Massachusetts General Hospital: Lessons Learned 

      Brunelle, Cheryl; Skolny, Melissa; Ferguson, Chantal; Swaroop, Meyha; O’Toole, Jean; Taghian, Alphonse G. (MDPI, 2015)
      There has been an increasing call to prospectively screen patients with breast cancer for the development of breast cancer-related lymphedema (BCRL) following their breast cancer treatment. While the components of a ...

    • Establishing Chromatin Regulatory Landscape during Mouse Preimplantation Development 

      Lu, Falong; Liu, Yuting; Inoue, Azusa; Suzuki, Tsukasa; Zhao, Keji; Zhang, Yi (Elsevier BV, 2016)
      How the chromatin regulatory landscape in the inner cell mass cells is established from differentially packaged sperm and egg genomes during preimplantation development is unknown. Here, we develop a low-input DNase I ...

    • Establishing the effectiveness of patient decision aids: key constructs and measurement instruments 

      Sepucha, Karen R; Borkhoff, Cornelia M; Lally, Joanne; Levin, Carrie A; Matlock, Daniel D; Ng, Chirk Jenn; Ropka, Mary E; Stacey, Dawn; Joseph-Williams, Natalie; Wills, Celia E; Thomson, Richard (BioMed Central, 2013)
      Background: Establishing the effectiveness of patient decision aids (PtDA) requires evidence that PtDAs improve the quality of the decision-making process and the quality of the choice made, or decision quality. The aim ...

    • Establishment of a General Medicine Residency Training Program in Rural West Africa 

      Drislane, Frank W.; Akpalu, Albert; Wegdam, Harry H.J. (YJBM, 2014)
      Ghana, a developing country in West Africa, has major medical burdens in taking care of a large population with limited resources. Its three medical schools produce more than 200 graduates per year, but most emigrate to ...

    • Establishment of a Humanized APL Model via the Transplantation of PML-RARA-Transduced Human Common Myeloid Progenitors into Immunodeficient Mice 

      Matsushita, Hiromichi; Yahata, Takashi; Sheng, Yin; Nakamura, Yoshihiko; Muguruma, Yukari; Matsuzawa, Hideyuki; Tanaka, Masayuki; Hayashi, Hideki; Sato, Tadayuki; Damdinsuren, Anar; Onizuka, Makoto; Ito, Mamoru; Miyachi, Hayato; Pandolfi, Pier Paolo; Ando, Kiyoshi (Public Library of Science, 2014)
      Recent advances in cancer biology have revealed that many malignancies possess a hierarchal system, and leukemic stem cells (LSC) or leukemia-initiating cells (LIC) appear to be obligatory for disease progression. Acute ...

    • Establishment of a novel in vitro model of stratified epithelial wound healing with barrier function 

      Gonzalez-Andrades, Miguel; Alonso-Pastor, Luis; Mauris, Jérôme; Cruzat, Andrea; Dohlman, Claes H.; Argüeso, Pablo (Nature Publishing Group, 2016)
      The repair of wounds through collective movement of epithelial cells is a fundamental process in multicellular organisms. In stratified epithelia such as the cornea and skin, healing occurs in three steps that include a ...

    • Estimated age and gender profile of individuals missed by a home-based HIV testing and counselling campaign in a Botswana community 

      Novitsky, Vlad; Bussmann, Hermann; Okui, Lillian; Logan, Andrew; Moyo, Sikhulile; van Widenfelt, Erik; Mmalane, Mompati; Lei, Quanhong; Holme, Molly P; Makhema, Joseph; Lockman, Shahin; Degruttola, Victor; Essex, M (International AIDS Society, 2015)
      Introduction: It would be useful to understand which populations are not reached by home-based HIV-1 testing and counselling (HTC) to improve strategies aimed at linking these individuals to care and reducing rates of ...

    • Estimated Cost of Emergency Sunburn Visits—Validation of ICD-9-CM Search Criteria 

      Xia, Fan; Joyce, Cara; Mostaghimi, Arash (American Medical Association (AMA), 2017)
      To the Editor We applaud the evaluation by Guy and colleagues of costs for sunburn-associated visits to US emergency departments. Their analysis was performed using the International Classification of Diseases, Ninth ...

    • Estimated Costs of False Laboratory Diagnoses of Tuberculosis in Three Patients 

      Northrup, Jill M.; Sharnprapai, Sharon; Etkind, Sue; Driscoll, Jeffrey; McGarry, Michael; Taber, Harry W.; Elvin, Paul; Qualls, Noreen L.; Braden, Christopher R.; Miller, Ann C.; Nardell, Edward Anthony (Centers for Disease Control and Prevention, 2002)
      We estimated direct medical and nonmedical costs associated with a false diagnosis of tuberculosis (TB) caused by laboratory cross-contamination of Mycobacterium tuberculosis cultures in Massachusetts in 1998 and 1999. For ...

    • Estimated effective dose of CT-guided percutaneous cryoablation of liver tumors 

      Park, Byung Kwan; Morrison, Paul T; Tatli, Servet; Govindarajulu, Usha; Tuncali, Kemal; Judy, Philip Frank; Shyn, Paul B.; Silverman, Stuart George (Elsevier BV, 2012)
      Purpose: To estimate effective dose during CT-guided cryoablation of liver tumors, and to assess which procedural factors contribute most to dose. Materials and methods: Our institutional review board approved this ...

    • Estimates of benefits and harms of prophylactic use of aspirin in the general population 

      Cuzick, J.; Thorat, M. A.; Bosetti, C.; Brown, P. H.; Burn, J.; Cook, N. R.; Ford, L. G.; Jacobs, E. J.; Jankowski, J. A.; La Vecchia, C.; Law, M.; Meyskens, F.; Rothwell, P. M.; Senn, H. J.; Umar, A. (Oxford University Press, 2014)
      Background: Accumulating evidence supports an effect of aspirin in reducing overall cancer incidence and mortality in the general population. We reviewed current data and assessed the benefits and harms of prophylactic use ...

    • Estimates of Electronic Medical Records in U.S. Emergency Departments 

      Geisler, Benjamin P.; Schuur, Jeremiah D; Pallin, Daniel J. (Public Library of Science, 2010)
      Background: Policymakers advocate universal electronic medical records (EMRs) and propose incentives for “meaningful use” of EMRs. Though emergency departments (EDs) are particularly sensitive to the benefits and unintended ...

    • Estimating age-based antiretroviral therapy costs for HIV-infected children in resource-limited settings based on World Health Organization weight-based dosing recommendations 

      Doherty, Kathleen; Essajee, Shaffiq; Penazzato, Martina; Holmes, Charles; Resch, Stephen; Ciaranello, Andrea (BioMed Central, 2014)
      Background: Pediatric antiretroviral therapy (ART) has been shown to substantially reduce morbidity and mortality in HIV-infected infants and children. To accurately project program costs, analysts need accurate estimations ...

    • Estimating Causal Effects of Local Air Pollution on Daily Deaths: Effect of Low Levels 

      Schwartz, Joel; Bind, Marie-Abele; Koutrakis, Petros (National Institute of Environmental Health Sciences, 2016)
      Background: Although many time-series studies have established associations of daily pollution variations with daily deaths, there are fewer at low concentrations, or focused on locally generated pollution, which is becoming ...

    • Estimating Causal Effects of Long-Term PM2.5 Exposure on Mortality in New Jersey 

      Wang, Yan; Kloog, Itai; Coull, Brent A.; Kosheleva, Anna; Zanobetti, Antonella; Schwartz, Joel D. (National Institute of Environmental Health Sciences, 2016)
      Background: Many studies have reported the associations between long-term exposure to PM2.5 and increased risk of death. However, to our knowledge, none has used a causal modeling approach or controlled for long-term ...

    • Estimating cost-offsets of new medications: Use of new antipsychotics and mental health costs for schizophrenia 

      O'Malley, Alistair James; Frank, Richard Gabriel; Normand, S-L T (John Wiley & Sons, Ltd., 2011)
      Estimation of the effect of one treatment compared to another in the absence of randomization is a common problem in biostatistics. An increasingly popular approach involves instrumental variables—variables that are ...

    • Estimating Effects of Arsenic Exposure During Pregnancy on Perinatal Outcomes in a Bangladeshi Cohort 

      Kile, Molly L.; Cardenas, Andres; Rodrigues, Ema; Mazumdar, Maitreyi; Dobson, Christine; Golam, Mostofa; Quamruzzaman, Quazi; Rahman, Mahmudar; Christiani, David C. (Lippincott Williams & Wilkins, 2015)
      Background: The relationship between arsenic and birth weight is not well understood. The objective was to evaluate the causal relationship between prenatal arsenic exposure and birth weight considering the potential ...