Browsing HMS Scholarly Articles by Title

Now showing items 634-653 of 17922

    • Altered metabolic requirements in cancer cell migration and metastasis 

      Lee, Jaewon; Ng, Mei Rosa; Sinkevicius, Kerstin Wolf; Kim, Carla; Danuser, Gaudenz; Brugge, Joan S.; Haigis, Marcia C. (BioMed Central, 2012)

    • Altered Metabolism in Cancer 

      Locasale, Jason Wei; Cantley, Lewis C. (BioMed Central, 2010)
      Cancer cells have different metabolic requirements from their normal counterparts. Understanding the consequences of this differential metabolism requires a detailed understanding of glucose metabolism and its relation to ...

    • Altered Monocyte Phenotype in HIV-1 Infection Tends to Normalize with Integrase-Inhibitor-Based Antiretroviral Therapy 

      McCausland, Marie R.; Juchnowski, Steven M.; Zidar, David A.; Kuritzkes, Daniel R.; Andrade, Adriana; Sieg, Scott F.; Lederman, Michael M.; Funderburg, Nicholas T. (Public Library of Science, 2015)
      Background: Monocytes are increasingly implicated in the inflammatory consequences of HIV-1 disease, yet their phenotype following antiretroviral therapy (ART) initiation is incompletely defined. Here, we define more ...

    • Altered NK cell function in obese healthy humans 

      Laue, Tobias; Wrann, Christiane D; Hoffmann-Castendiek, Birgit; Pietsch, Daniel; Hübner, Lena; Kielstein, Heike (BioMed Central, 2015)
      Background: Obesity is associated with an elevated risk for several types of cancer and thus a major health hazard. However, the mechanism between overweight and cancer susceptibility is still elusive. Leptin, mainly ...

    • Altered Onset Response Dynamics in Somatosensory Processing in Autism Spectrum Disorder 

      Khan, Sheraz; Hashmi, Javeria A.; Mamashli, Fahimeh; Bharadwaj, Hari M.; Ganesan, Santosh; Michmizos, Konstantinos P.; Kitzbichler, Manfred G.; Zetino, Manuel; Garel, Keri-Lee A.; Hämäläinen, Matti S.; Kenet, Tal (Frontiers Media S.A., 2016)
      Abnormalities in cortical connectivity and evoked responses have been extensively documented in autism spectrum disorder (ASD). However, specific signatures of these cortical abnormalities remain elusive, with data pointing ...

    • Altered orbitofrontal sulcogyral pattern in schizophrenia 

      Nakamura, M.; Nestor, Paul Gerard; McCarley, Robert William; Levitt, James Jonathan; Hsu, Liangge; Kawashima, T.; Niznikiewicz, Margaret A.; Shenton, Martha Elizabeth (Oxford University Press (OUP), 2007)
      Orbitofrontal alteration in schizophrenia has not been well characterized, likely due to marked anatomical variability. To investigate the presence of such alterations, we evaluated the sulcogyral pattern of this ‘H-shaped’ ...

    • Altered periaqueductal gray resting state functional connectivity in migraine and the modulation effect of treatment 

      Li, Zhengjie; Liu, Mailan; Lan, Lei; Zeng, Fang; Makris, Nikos; Liang, Yilin; Guo, Taipin; Wu, Feng; Gao, Yujie; Dong, Mingkai; Yang, Jie; Li, Ying; Gong, Qiyong; Liang, Fanrong; Kong, Jian (Nature Publishing Group, 2016)
      The aims of this study were to 1) compare resting state functional connectivity (rs-fc) of the periaqueductal gray (PAG), a key region in the descending pain modulatory system (DPMS) between migraine without aura (MwoA) ...

    • Altered ratios of pro‐ and anti‐angiogenic VEGF‐A variants and pericyte expression of DLL4 disrupt vascular maturation in infantile haemangioma 

      Ye, Xi; Abou‐Rayyah, Yassir; Bischoff, Joyce; Ritchie, Alison; Sebire, Neil J; Watts, Patrick; Churchill, Amanda J; Bates, David O (John Wiley & Sons, Ltd, 2016)
      Abstract Infantile haemangioma (IH), the most common neoplasm in infants, is a slowly resolving vascular tumour. Vascular endothelial growth factor A (VEGF‐A), which consists of both the pro‐ and anti‐angiogenic variants, ...

    • Altered Resting State Connectivity of the Insular Cortex in Individuals With Fibromyalgia 

      Ichesco, Eric; Schmidt-Wilcke, Tobias; Bhavsar, Rupal; Clauw, Daniel J.; Peltier, Scott J.; Kim, Jieun; Napadow, Vitaly J.; Hampson, Johnson P.; Kairys, Anson E.; Williams, David A.; Harris, Richard E. (Elsevier BV, 2014)
      The insular (IC) and cingulate cortices (CC) are critically involved in pain perception. Previously we demonstrated that fibromyalgia (FM) patients have greater connectivity between the insula and Default Mode Network at ...

    • Altered resting-state EEG source functional connectivity in schizophrenia: the effect of illness duration 

      Di Lorenzo, Giorgio; Daverio, Andrea; Ferrentino, Fabiola; Santarnecchi, Emiliano; Ciabattini, Fabio; Monaco, Leonardo; Lisi, Giulia; Barone, Ylenia; Di Lorenzo, Cherubino; Niolu, Cinzia; Seri, Stefano; Siracusano, Alberto (Frontiers Media S.A., 2015)
      Despite the increasing body of evidence supporting the hypothesis of schizophrenia as a disconnection syndrome, studies of resting-state EEG Source Functional Connectivity (EEG-SFC) in people affected by schizophrenia are ...

    • Altered serum levels of kynurenine metabolites in patients affected by cluster headache 

      Curto, Martina; Lionetto, Luana; Negro, Andrea; Capi, Matilde; Perugino, Francesca; Fazio, Francesco; Giamberardino, Maria Adele; Simmaco, Maurizio; Nicoletti, Ferdinando; Martelletti, Paolo (Springer Milan, 2016)
      Background: The reported efficacy of memantine in the treatment of patients with cluster headache (CH) suggests that NMDA receptors are involved in mechanisms of nociceptive sensitization within the trigeminal system ...

    • Altered Small-World Brain Networks in Schizophrenia Patients during Working Memory Performance 

      He, Hao; Sui, Jing; Yu, Qingbao; Turner, Jessica A.; Ho, Beng-Choon; Sponheim, Scott R.; Manoach, Dara S.; Clark, Vincent P.; Calhoun, Vince D. (Public Library of Science, 2012)
      Impairment of working memory (WM) performance in schizophrenia patients (SZ) is well-established. Compared to healthy controls (HC), SZ patients show aberrant blood oxygen level dependent (BOLD) activations and disrupted ...

    • Altered sphingoid base profiles in type 1 compared to type 2 diabetes 

      Wei, Nancy; Pan, Jessica; Pop-Busui, Rodica; Othman, Alaa; Alecu, Irina; Hornemann, Thorsten; Eichler, Florian S (BioMed Central, 2014)
      Background: Sphingolipids are increasingly recognized to play a role in insulin resistance and diabetes. Recently we reported significant elevations of 1-deoxysphingolipids (1-deoxySL) - an atypical class of sphingolipids ...

    • Altered threat and safety neural processing linked to persecutory delusions in schizophrenia: a two-task fMRI study 

      Perez, David Lewis; Pan, Hong; Weisholtz, Daniel; Root, James C.; Tuescher, Oliver; Fischer, David Benjamin; Butler, Tracy; Vago, David R.; Isenberg, Nancy; Epstein, Jane Ingrid; Landa, Yulia; Smith, Thomas J.; Savitz, Adam J.; Silbersweig, David A; Stern, Emily (Elsevier BV, 2015)
      Persecutory delusions are a clinically important symptom in schizophrenia associated with social avoidance and increased violence. Few studies have investigated the neurobiology of persecutory delusions, which is a ...

    • Altered translation of GATA1 in Diamond-Blackfan anemia 

      Ludwig, Leif S.; Gazda, Hanna T.; Eng, Jennifer C.; Eichhorn, Stephen W.; Thiru, Prathapan; Ghazvinian, Roxanne; George, Tracy I.; Gotlib, Jason R.; Beggs, Alan H.; Sieff, Colin A.; Lodish, Harvey F.; Lander, Eric S.; Sankaran, Vijay G. (2014)
      Ribosomal protein haploinsufficiency occurs in diverse human diseases including Diamond-Blackfan anemia (DBA),1,2 congenital asplenia,3 and T-cell leukemia.4 Yet how mutations in such ubiquitously expressed proteins result ...

    • Altered white matter integrity in individuals with cognitive vulnerability to depression: a tract-based spatial statistics study 

      Xiao, Jing; He, Yini; McWhinnie, Chad M.; Yao, Shuqiao (Nature Publishing Group, 2015)
      The microstructure of white matter in patients with major depressive disorder (MDD) has been demonstrated to be abnormal. However, it remains unclear whether these changes exist prior to the onset of disease. In this study, ...

    • Altering the Insertional Specificity of a Drosophila Transposable Element 

      Kassis, Judith A.; Noll, Elizabeth; VanSickle, E. Page; Odenwald, Ward F.; Perrimon, Norbert (National Academy of Sciences, 1992-03-01)
      Vectors derived from the Drosophila P element transposon are widely used to make transgenic Drosophila. Insertion of most P-element-derived vectors is nonrandom, but they exhibit a broad specificity of target sites. During ...

    • Alternate Healthy Eating Index 2010 and risk of chronic obstructive pulmonary disease among US women and men: prospective study 

      Varraso, Raphaëlle; Chiuve, Stephanie E; Fung, Teresa T; Barr, R Graham; Hu, Frank B; Willett, Walter C; Camargo, Carlos A (BMJ Publishing Group Ltd., 2015)
      Objective: To investigate the association between the Alternate Healthy Eating Index 2010 (AHEI-2010)—a measure of diet quality—and the risk of chronic obstructive pulmonary disease (COPD). Design: Prospective cohort study. ...

    • Alternate Splicing of Interleukin-1 Receptor Type II (IL1R2) In Vitro Correlates with Clinical Glucocorticoid Responsiveness in Patients with AIED 

      Vambutas, Andrea; DeVoti, James; Goldofsky, Elliot; Gordon, Michael Scott; Lesser, Martin; Bonagura, Vincent (Public Library of Science, 2009)
      Autoimmune Inner Ear Disease (AIED) is poorly characterized clinically, with no definitive laboratory test. All patients suspected of having AIED are given glucocorticoids during periods of acute hearing loss, however, ...

    • Alternative Calculations of Individual Patient Time in Therapeutic Range While Taking Warfarin: Results From the ROCKET AF Trial 

      Singer, Daniel E.; Hellkamp, Anne S.; Yuan, Zhong; Lokhnygina, Yuliya; Patel, Manesh R.; Piccini, Jonathan P.; Hankey, Graeme J.; Breithardt, Günter; Halperin, Jonathan L.; Becker, Richard C.; Hacke, Werner; Nessel, Christopher C.; Mahaffey, Kenneth W.; Fox, Keith A. A.; Califf, Robert M. (Blackwell Publishing Ltd, 2015)
      Background: In the ROCKET AF (Rivaroxaban–Once‐daily, oral, direct Factor Xa inhibition Compared with vitamin K antagonism for prevention of stroke and Embolism Trial in Atrial Fibrillation) trial, marked regional differences ...