Browsing HMS Scholarly Articles by Keyword "bipolar disorder"

Now showing items 1-13 of 13

    • A brief review of exercise, bipolar disorder, and mechanistic pathways 

      Thomson, Daniel; Turner, Alyna; Lauder, Sue; Gigler, Margaret E.; Berk, Lesley; Singh, Ajeet B.; Pasco, Julie A.; Berk, Michael; Sylvia, Louisa (Frontiers Media S.A., 2015)
      Despite evidence that exercise has been found to be effective in the treatment of depression, it is unclear whether these data can be extrapolated to bipolar disorder. Available evidence for bipolar disorder is scant, with ...

    • Characterization of Bipolar Disorder Patient-Specific Induced Pluripotent Stem Cells from a Family Reveals Neurodevelopmental and mRNA Expression Abnormalities 

      Madison, Jon M.; Zhou, Fen; Nigam, Aparna; Hussain, Ali; Barker, Douglas D.; Nehme, Ralda; van der Ven, Karlijn; Hsu, Jenny; Wolf, Pavlina; Fleishman, Morgan; O’Dushlaine, Colm; Rose, Sam; Chambert, Kimberly; Lau, Frank H.; Ahfeldt, Tim; Rueckert, Erroll H.; Sheridan, Steven D.; Fass, Daniel M.; Nemesh, James; Mullen, Thomas E.; Daheron, Laurence; McCarroll, Steve; Sklar, Pamela; Perlis, Roy H.; Haggarty, Stephen J. (2014)
      Bipolar disorder (BD) is a common neuropsychiatric disorder characterized by chronic recurrent episodes of depression and mania. Despite evidence for high heritability of BD, little is known about its underlying pathophysiology. ...

    • Combining ERP and Structural MRI Information in First Episode Schizophrenia and Bipolar Disorder 

      McCarley, Robert William; Nakamura, M.; Shenton, Martha Elizabeth; Salisbury, D. F. (SAGE Publications, 2008)
      The electrical activity in the electroencephalogram (EEG) and the event-related potentials extracted from the EEG provide the greatest temporal resolution for examining brain function. When coupled with the high spatial ...

    • Common and Specific Elements of Psychosocial Treatments for Bipolar Disorder: A Survey of Clinicians Participating in Randomized Trials 

      Miklowitz, David J.; Goodwin, Guy M.; Bauer, Mark S; Geddes, John R. (Ovid Technologies (Wolters Kluwer Health), 2008)
      Background There are 14 randomized trials that indicate the benefits of various adjunctive psychosocial interventions for bipolar disorder. Efficient planning of future interventions requires identification of the common, ...

    • Dysregulation of miR-34a Links Neuronal Development to Genetic Risk Factors for Bipolar Disorder 

      Bavamian, Sabine; Mellios, Nikolaos; Lalonde, Jasmin; Fass, Daniel M.; Wang, Jennifer; Sheridan, Steven D.; Madison, Jon M.; Zhou, Fen; Rueckert, Erroll H.; Barker, Doug; Perlis, Roy H.; Sur, Mriganka; Haggarty, Stephen J. (2014)
      Bipolar disorder (BD) is a heritable neuropsychiatric disorder with largely unknown pathogenesis. Given their prominent role in brain function and disease, we hypothesized that microRNAs (miRNAs) might be of importance for ...

    • The functional impact of subsyndromal depressive symptoms in bipolar disorder: Data from STEP-BD 

      Marangell, Lauren B.; Dennehy, Ellen B.; Miyahara, Sachiko; Wisniewski, Stephen R.; Bauer, Mark S; Rapaport, Mark Hyman; Allen, Michael H. (Elsevier BV, 2009)
      Background This report describes baseline characteristics and functional outcomes of subjects who have prospectively observed subsyndromal symptoms after a major depressive episode (MDE). Methods All subjects were ...

    • Gamma-Band Auditory Steady-State Responses Are Impaired in First Episode Psychosis 

      Spencer, Kevin M.; Salisbury, Dean F.; Shenton, Martha Elizabeth; McCarley, Robert William (Elsevier BV, 2008)
      Background: In chronic schizophrenia and chronic bipolar disorder, gamma band (30–100 Hz) auditory steady-state EEG responses (ASSRs) are reduced in power and phase locking, likely reflecting neural circuit dysfunction. ...

    • A Longitudinal Pilot Proton MRS Investigation of the Manic and Euthymic States of Bipolar Disorder 

      Brady, Roscoe Owen; Cooper, Anne; Jensen, John Eric; Tandon, Neeraj; Cohen, Bruce Michael; Renshaw, Perry Franklin; Keshavan, Matcheri S; Öngür, Dost (Nature Publishing Group, 2012)
      Several lines of evidence implicate dysfunction in brain energy production as a key component of bipolar disorder. In particular, elevated brain lactate levels observed in this condition suggest a shift from aerobic to ...

    • Lurasidone for the treatment of bipolar depression: an evidence-based review 

      Franklin, Rachel; Zorowitz, Sam; Corse, Andrew K; Widge, Alik S; Deckersbach, Thilo (Dove Medical Press, 2015)
      Bipolar disorder (BD) is a debilitating and difficult-to-treat psychiatric disease that presents a serious burden to patients’ lives as well as health care systems around the world. The essential diagnostic criterion for ...

    • Neocortical Gray Matter Volume in First-Episode Schizophrenia and First-Episode Affective Psychosis: A Cross-Sectional and Longitudinal MRI Study 

      Nakamura, Motoaki; Salisbury, Dean F.; Hirayasu, Yoshio; Bouix, Sylvain; Pohl, Kilian M.; Yoshida, Takeshi; Koo, Min-Seong; Shenton, Martha Elizabeth; McCarley, Robert William (Elsevier BV, 2007)
      Background: Overall neocortical gray matter (NCGM) volume has not been studied in first-episode schizophrenia (FESZ) at first hospitalization or longitudinally to evaluate progression, nor has it been compared with ...

    • Quality of life among patients with bipolar disorder in primary care versus community mental health settings 

      Miller, Christopher Joseph; Abraham, Kristen M.; Bajor, Laura Ann; Lai, Zongshan; Kim, Hyungjin Myra; Nord, Kristina M.; Goodrich, David E.; Bauer, Mark S; Kilbourne, Amy M. (Elsevier BV, 2013)
      Introduction Bipolar disorder is associated with functional impairment across a number of domains, including health-related quality of life (HRQOL). Many patients are treated exclusively in primary care (PC) settings, ...

    • Reward Learning, Neurocognition, Social Cognition, and Symptomatology in Psychosis 

      Lewandowski, Kathryn E.; Whitton, Alexis E.; Pizzagalli, Diego A.; Norris, Lesley A.; Ongur, Dost; Hall, Mei-Hua (Frontiers Media S.A., 2016)
      Background: Patients with psychosis spectrum disorders exhibit deficits in social and neurocognition, as well as hallmark abnormalities in motivation and reward processing. Aspects of reward processing may overlap behaviorally ...

    • The role of sleep in bipolar disorder 

      Gold, Alexandra K; Sylvia, Louisa G (Dove Medical Press, 2016)
      Bipolar disorder is a serious mental illness characterized by alternating periods of elevated and depressed mood. Sleep disturbances in bipolar disorder are present during all stages of the condition and exert a negative ...